Author results

4EVM
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1.5 ANGSTROM CRYSTAL STRUCTURE OF SOLUBLE DOMAIN OF MEMBRANE-ANCHORED THIOREDOXIN FAMILY PROTEIN FROM STREPTOCOCCUS PNEUMONIAE STRAIN CANADA MDR_19A
Descriptor:Thioredoxin family protein
Authors:Wawrzak, Z., Stogios, P.J., Minasov, G., Kudritska, M., Yim, V., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-04-26
Release date:2012-05-09
Method:X-RAY DIFFRACTION (1.506 Å)
Cite:1.5 Angstrom crystal structure of soluble domain of membrane-anchored thioredoxin family protein from Streptococcus pneumoniae strain Canada MDR_19A
To be Published
4STD
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HIGH RESOLUTION STRUCTURES OF SCYTALONE DEHYDRATASE-INHIBITOR COMPLEXES CRYSTALLIZED AT PHYSIOLOGICAL PH
Descriptor:Scytalone dehydratase, N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO SALICYLAMIDE
Authors:Wawrzak, Z., Sandalova, T., Steffens, J.J., Basarab, G.S., Lundqvist, T., Lindqvist, Y., Jordan, D.B.
Deposit date:1999-02-10
Release date:1999-12-29
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH.
Proteins, 35, 1999
5STD
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SCYTALONE DEHYDRATASE PLUS INHIBITOR 2
Descriptor:Scytalone dehydratase, CALCIUM ION, (6,7-DIFLUORO-QUINAZOLIN-4-YL)-(1-METHYL-2,2-DIPHENYL-ETHYL)-AMINE
Authors:Wawrzak, Z., Sandalova, T., Steffens, J.J., Basarab, G.S., Lundqvist, T., Lindqvist, Y., Jordan, D.B.
Deposit date:1999-02-10
Release date:1999-12-29
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH.
Proteins, 35, 1999
6STD
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SCYTALONE DEHYDRATASE PLUS INHIBITOR 3
Descriptor:Scytalone dehydratase, CALCIUM ION, 2,2-DICHLORO-1-METHANESULFINYL-3-METHYL-CYCLOPROPANECARBOXYLIC ACID [1-(4-BROMO-PHENYL)-ETHYL]-AMIDE
Authors:Wawrzak, Z., Sandalova, T., Steffens, J.J., Basarab, G.S., Lundqvist, T., Lindqvist, Y., Jordan, D.B.
Deposit date:1999-02-11
Release date:1999-12-29
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH.
Proteins, 35, 1999
7STD
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SCYTALONE DEHYDRATASE PLUS INHIBITOR 4
Descriptor:Scytalone dehydratase, CALCIUM ION, ((1RS,3SR)-2,2-DICHLORO-N-[(R)-1-(4-CHLOROPHENYL)ETHYL]-1-ETHYL-3-METHYLCYCLOPROPANECARBOXAMIDE
Authors:Wawrzak, Z., Sandalova, T., Steffens, J.J., Basarab, G.S., Lundqvist, T., Lindqvist, Y., Jordan, D.B.
Deposit date:1999-02-11
Release date:1999-12-29
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH.
Proteins, 35, 1999
4H6O
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STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH THE INHIBITOR NEU321 (1-(3-(4-CHLORO-3,5-DIMETHYLPHENOXY)BENZYL)-1H-IMIDAZOLE
Descriptor:Sterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 1-[3-(4-chloro-3,5-dimethylphenoxy)benzyl]-1H-imidazole
Authors:Wawrzak, Z., Hargrove, T.Y., Pollastri, M.P., Lepesheva, G.I.
Deposit date:2012-09-19
Release date:2013-03-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth.
J.Med.Chem., 56, 2013
5AJR
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STEROL 14-ALPHA DEMETHYLASE (CYP51) FROM TRYPANOSOMA CRUZI IN COMPLEX WITH THE 1-TETRAZOLE DERIVATIVE VT-1161 ((R)-2-(2,4-DIFLUOROPHENYL)-1, 1-DIFLUORO-3-(1H-TETRAZOL-1-YL)-1-(5-(4-(2,2,2-TRIFLUOROETHOXY)PHENYL) PYRIDIN-2-YL)PROPAN-2-OL)
Descriptor:STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol
Authors:Wawrzak, Z., Hoekstra, W., I Lepesheva, G.
Deposit date:2015-02-26
Release date:2015-12-02
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Clinical Candidate Vt-1161'S Antiparasitic Effect in Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme Cyp51 from Trypanosoma Cruzi.
Antimicrob.Agents Chemother., 60, 2015
1LLF
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CHOLESTEROL ESTERASE (CANDIDA CYLINDRACEA) CRYSTAL STRUCTURE AT 1.4A RESOLUTION
Descriptor:Lipase 3, N-ACETYL-D-GLUCOSAMINE, TRICOSANOIC ACID
Authors:Pletnev, V., Addlagatta, A., Wawrzak, Z., Duax, W.
Deposit date:2002-04-28
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
1TW7
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WIDE OPEN 1.3A STRUCTURE OF A MULTI-DRUG RESISTANT HIV-1 PROTEASE REPRESENTS A NOVEL DRUG TARGET
Descriptor:protease, SODIUM ION
Authors:Martin, P., Vickrey, J.F., Proteasa, G., Jimenez, Y.L., Wawrzak, Z., Winters, M.A., Merigan, T.C., Kovari, L.C.
Deposit date:2004-06-30
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
Structure, 13, 2005
1MA8
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A-DNA DECAMER GCGTA(UMS)ACGC WITH INCORPORATED 2'-METHYLSELENO-URIDINE
Descriptor:5'-D(*GP*CP*GP*TP*AP*UMSP*AP*CP*GP*C)-3'
Authors:Teplova, M., Wilds, C.J., Wawrzak, Z., Tereshko, V., Du, Q., Carrasco, N., Huang, Z., Egli, M.
Deposit date:2002-08-01
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle
BIOCHIMIE, 84, 2002
3IR4
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1.2 ANGSTROM CRYSTAL STRUCTURE OF THE GLUTAREDOXIN 2 (GRXB) FROM SALMONELLA TYPHIMURIUM IN COMPLEX WITH GLUTATHIONE
Descriptor:Glutaredoxin 2, GLUTATHIONE, CHLORIDE ION, ...
Authors:Minasov, G., Wawrzak, Z., Skarina, T., Onopriyenko, O., Peterson, S.N., Halavaty, A., Dauter, Z., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2009-08-21
Release date:2009-09-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:1.2 Angstrom Crystal Structure of the Glutaredoxin 2 (grxB) from Salmonella typhimurium in complex with Glutathione.
TO BE PUBLISHED
3OQ7
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV-1 Protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-09-02
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
3OQA
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV-1 Protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-09-02
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
3OQD
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV-1 Protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-09-02
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
3PJ6
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CRYSTAL STRUCTURES OF MULTIDRUG-RESISTANT CLINICAL ISOLATE 769 HIV-1 PROTEASE VARIANTS
Descriptor:HIV protease
Authors:Yedidi, R.S., Proteasa, G., Martinez-Cajas, J.L., Vickrey, J.F., Martin, P.D., Wawrzak, Z., Kovari, L.C.
Deposit date:2010-11-08
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
4YWZ
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR RECEPTOR DOMAIN OF THE ESSENTIAL SENSOR KINASE WALK FROM STAPHYLOCOCCUS AUREUS
Descriptor:Sensor protein kinase WalK
Authors:Ji, Q., Wawrzak, Z., He, C.
Deposit date:2015-03-21
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
Nat Commun, 7, 2016
1G57
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CRYSTAL STRUCTURE OF 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE
Descriptor:3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE, CESIUM ION
Authors:Liao, D.-I., Calabrese, J.C., Wawrzak, Z., Viitanen, P.V., Jordan, D.B.
Deposit date:2000-10-30
Release date:2001-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis.
Structure, 9, 2001
1G58
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CRYSTAL STRUCTURE OF 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE GOLD DERIVATIVE
Descriptor:3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE, GOLD ION
Authors:Liao, D.-I., Calabrese, J.C., Wawrzak, Z., Viitanen, P.V., Jordan, D.B.
Deposit date:2000-10-30
Release date:2001-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis.
Structure, 9, 2001
1I0F
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1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-AMINOOXYETHYL THYMINE IN PLACE OF T6, BA-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(127)P*AP*CP*GP*C)-3', BARIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0G
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1.45 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, MEDIUM NA-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', SODIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0J
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1.06 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE (T23) THYMINE IN PLACE OF T6, HIGH CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0K
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1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0M
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1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, HIGH RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0N
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1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0O
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1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE THYMINE IN PLACE OF T6, HIGH K-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', POTASSIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments
Nucleic Acids Res., 29, 2001