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4F9W
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HUMAN P38ALPHA MAPK IN COMPLEX WITH A NOVEL AND SELECTIVE SMALL MOLECULE INHIBITOR
Descriptor:Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, N,N-dimethyl-6-(naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3-amine, ...
Authors:Grum-Tokars, V.L., Minasov, G., Anderson, W.F., Watterson, D.M.
Deposit date:2012-05-21
Release date:2013-06-05
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
Plos One, 8, 2013
4F9Y
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HUMAN P38 ALPHA MAPK IN COMPLEX WITH A NOVEL AND SELECTIVE SMALL MOLECULE INHIBITOR
Descriptor:Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, N,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine, ...
Authors:Grum-Tokars, V.L., Minasov, G., Anderson, W.F., Watterson, D.M.
Deposit date:2012-05-21
Release date:2013-06-05
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
Plos One, 8, 2013
4FA2
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HUMAN P38 ALPHA MITOGEN-ACTIVATED KINASE IN COMPLEX WITH SB239063
Descriptor:Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, trans-4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl]cyclohexanol, ...
Authors:Grum-Tokars, V.L., Minasov, G., Anderson, W.F., Watterson, D.M.
Deposit date:2012-05-21
Release date:2013-06-05
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
Plos One, 8, 2013
4YO4
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CRYSTAL STRUCTURE OF DAPK1 CATALYTIC DOMAIN IN COMPLEX WITH THE HINGE BINDING FRAGMENT PHTHALAZINE
Descriptor:Death-associated protein kinase 1, CHLORIDE ION, ACETATE ION, ...
Authors:Grum-Tokars, V.L., Roy, S.M., Minasov, G., Anderson, W.F., Watterson, D.M.
Deposit date:2015-03-11
Release date:2015-05-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of DAPK1 catalytic domain in complex with hinge binding fragments
To Be Published
4YPD
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CRYSTAL STRUCTURE OF DAPK1 CATALYTIC DOMAIN IN COMPLEX WITH THE HINGE BINDING FRAGMENT 4-METHYLPYRIDAZINE
Descriptor:Death-associated protein kinase 1, CHLORIDE ION, SULFATE ION, ...
Authors:Grum-Tokars, V.L., Minasov, G., Roy, S.M., Anderson, W.F., Watterson, D.M.
Deposit date:2015-03-12
Release date:2015-05-13
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of DAPK1 catalytic domain in complex with hinge binding fragments
To Be Published
4EWQ
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HUMAN P38 ALPHA MAPK IN COMPLEX WITH A PYRIDAZINE BASED INHIBITOR
Descriptor:Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 3-phenyl-4-(pyridin-4-yl)-6-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine, ...
Authors:Grum-Tokars, V., Minasov, G., Roy, S., Schavocky, J., Winsor, J., Watterson, D.M., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-04-27
Release date:2012-06-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human p38 alpha MAP Kinase in complex with a pyridazine based inhibitor
To be Published
1IG1
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1.8A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MN.
Descriptor:death-associated protein kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-04-16
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKK
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2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG.
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-12
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKL
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1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-12
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKS
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1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-13
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1JKT
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TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE
Authors:Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D.M., Egli, M.
Deposit date:2001-07-13
Release date:2002-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nat.Struct.Biol., 8, 2001
1P4F
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DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
Descriptor:Death-associated protein kinase 1, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE
Authors:Velentza, A.V., Wainwright, M.S., Zasadzki, M., Mirzoeva, S., Haiech, J., Focia, P.J., Egli, M., Watterson, D.M.
Deposit date:2003-04-23
Release date:2004-09-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Bioorg.Med.Chem.Lett., 13, 2003
3DFC
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CRYSTAL STRUCTURE OF A GLYCINE-RICH LOOP MUTANT OF THE DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH AMPPNP
Descriptor:Death-associated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:McNamara, L.K., Schavocky, J.P., Watterson, D.M., Brunzelle, J.S.
Deposit date:2008-06-11
Release date:2009-05-26
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High resolution crystal structures of the death associated protein kinase catalytic domain with a key point mutation in the glycine-rich loop
To be Published
3DGK
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CRYSTAL STRUCTURE OF A GLYCINE-RICH LOOP MUTANT OF THE DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN
Descriptor:Death-associated protein kinase 1
Authors:McNamara, L.K., Schavocky, J.P., Watterson, D.M., Brunzelle, J.S.
Deposit date:2008-06-13
Release date:2009-05-26
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High resolution crystal structures of the death associated protein kinase catalytic domain with a key point mutation in the glycine-rich loop
To be Published
3EH9
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CRYSTAL STRUCTURE OF DEATH ASSOCIATED PROTEIN KINASE COMPLEXED WITH ADP
Descriptor:Death-associated protein kinase 1, ADENOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:McNamara, L.K., Watterson, D.M., Brunzelle, J.S.
Deposit date:2008-09-11
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insight into nucleotide recognition by human death-associated protein kinase.
Acta Crystallogr.,Sect.D, 65, 2009
3EHA
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CRYSTAL STRUCTURE OF DEATH ASSOCIATED PROTEIN KINASE COMPLEXED WITH AMPPNP
Descriptor:Death-associated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:McNamara, L.K., Watterson, D.M., Brunzelle, J.S.
Deposit date:2008-09-11
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural insight into nucleotide recognition by human death-associated protein kinase.
Acta Crystallogr.,Sect.D, 65, 2009
3F5G
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CRYSTAL STRUCTURE OF DEATH ASSOCIATED PROTEIN KINASE IN COMPLEX WITH ADP AND MG2+
Descriptor:Death-associated protein kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:McNamara, L.K., Watterson, D.M., Brunzelle, J.S.
Deposit date:2008-11-03
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural insight into nucleotide recognition by human death-associated protein kinase.
Acta Crystallogr.,Sect.D, 65, 2009
3F5U
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CRYSTAL STRUCTURE OF THE DEATH ASSOCIATED PROTEIN KINASE IN COMPLEX WITH AMPPNP AND MG2+
Descriptor:Death-associated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:McNamara, L.K., Watterson, D.M., Brunzelle, J.S.
Deposit date:2008-11-04
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insight into nucleotide recognition by human death-associated protein kinase.
Acta Crystallogr.,Sect.D, 65, 2009
3GU4
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CRYSTAL STRUCTURE OF DAPKQ23V-AMPPNP
Descriptor:Death-associated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:McNamara, L.K., Schavocky, J.S., Watterson, D.M., Brunzelle, J.S.
Deposit date:2009-03-28
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Enzymatic activity and crystallgoraphic analyses of a glycine-rich loop mutant of DAPK
To be Published
3GU5
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CRYSTAL STRUCTURE OF DAPKQ23V-AMPPNP-MG2+
Descriptor:Death-associated protein kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:McNamara, L.K., Schavocky, J.S., Watterson, D.M., Brunzelle, J.S.
Deposit date:2009-03-28
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Enzyme activity and crystallographic analyses of a glycine-rich loop mutant of DAPK
To be Published
3GU6
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CRYSTAL STRUCTURE OF DAPKQ23V-ADP
Descriptor:Death-associated protein kinase 1, ADENOSINE-5'-DIPHOSPHATE
Authors:McNamara, L.K., Schavocky, J.S., Watterson, D.M., Brunzelle, J.S.
Deposit date:2009-03-28
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Enzymatic activity and crystallographic analyses of a glycine-rich loop mutant of DAPK
To be Published
3GU7
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CRYSTAL STRUCTURE OF DAPKQ23V-ADP-MG2+
Descriptor:Death-associated protein kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:McNamara, L.K., Schavocky, J.S., Watterson, D.M., Brunzelle, J.S.
Deposit date:2009-03-28
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enzyme activity and crystallographic analyses of a glycine-rich loop mutant of DAPK
To be Published
3GU8
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CRYSTAL STRUCTURE OF DAPKL93G WITH N6-CYCLOPENTYLADENOSINE
Descriptor:Death-associated protein kinase 1, N6-cyclopentyladenosine
Authors:McNamara, L.K., Schumacher, A.M., Schavocky, J.S., Watterson, D.M., Brunzelle, J.S.
Deposit date:2009-03-28
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of the DAPK gatekeeper mutant with N6-modified adenosine analogs.
To be Published
3GUB
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CRYSTAL STRUCTURE OF DAPKL93G COMPLEXED WITH N6-(2-PHENYLETHYL)ADENOSINE
Descriptor:Death-associated protein kinase 1, 9-alpha-L-lyxofuranosyl-N-(2-phenylethyl)-9H-purin-6-amine, SULFATE ION
Authors:McNamara, L.K., Schumacher, A.M., Schavocky, J.S., Watterson, D.M., Brunzelle, J.S.
Deposit date:2009-03-29
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Crystal structures of the DAPK gatekeeper mutant complexed with N6-modified adenosine analogs.
To be Published
4R3C
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CRYSTAL STRUCTURE OF P38 ALPHA MAP KINASE IN COMPLEX WITH A NOVEL ISOFORM SELECTIVE DRUG CANDIDATE
Descriptor:Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, ...
Authors:Grum-Tokars, V.L., Minasov, G., Roy, S.M., Anderson, W.F., Watterson, D.M.
Deposit date:2014-08-14
Release date:2015-02-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.
ACS Chem Neurosci, 6, 2015
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