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1E50
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BU of 1e50 by Molmil
AML1/CBFbeta complex
Descriptor: CORE-BINDING FACTOR ALPHA SUBUNIT, CORE-BINDING FACTOR CBF-BETA
Authors:Warren, A.J, Bravo, J, Williams, R.L, Rabbits, T.H.
Deposit date:2000-07-13
Release date:2001-07-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for the Heterodimeric Interaction between the Acute Leukaemia-Associated Transcription Factors Aml1 and Cbfbeta
Embo J., 19, 2000
4ZXR
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BU of 4zxr by Molmil
Structure of Thaumatin wrapped in graphene within vacuum
Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Thaumatin-1
Authors:Aller, P, Warren, A.J, Trincao, J, Evans, G.
Deposit date:2015-05-20
Release date:2015-10-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:In vacuo X-ray data collection from graphene-wrapped protein crystals.
Acta Crystallogr.,Sect.D, 71, 2015
7QH6
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BU of 7qh6 by Molmil
Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 1
Descriptor: 16S ribosomal RNA, 39S ribosomal protein L13, mitochondrial, ...
Authors:Rebelo-Guiomar, P, Pellegrino, S, Dent, K.C, Warren, A.J, Minczuk, M.
Deposit date:2021-12-10
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Nat Commun, 13, 2022
7QH7
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BU of 7qh7 by Molmil
Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4
Descriptor: 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ...
Authors:Rebelo-Guiomar, P, Pellegrino, S, Dent, K.C, Warren, A.J, Minczuk, M.
Deposit date:2021-12-10
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Nat Commun, 13, 2022
7OW7
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BU of 7ow7 by Molmil
EIF6-bound large subunit of the human ribosome
Descriptor: 28S rRNA, 5.8S ribosomal RNA, 5S rRNA, ...
Authors:Faille, A, Warren, A.J.
Deposit date:2021-06-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structure of human EIF6-bound large ribosomal subunit
To Be Published
7R4X
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BU of 7r4x by Molmil
Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Pellegrino, S, Dent, K.C, Spikes, T, Warren, A.J.
Deposit date:2022-02-09
Release date:2023-02-22
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.15 Å)
Cite:Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 angstrom resolution.
Nucleic Acids Res., 51, 2023
6EZO
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BU of 6ezo by Molmil
Eukaryotic initiation factor EIF2B in complex with ISRIB
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Human eukaryotic initiation factor EIF2B epsilon subunits, Translation initiation factor eIF-2B subunit alpha, ...
Authors:Faille, A, Weis, F, Zyryanova, A, Warren, A.J, Ron, D.
Deposit date:2017-11-16
Release date:2018-03-28
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Science, 359, 2018
8BP2
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BU of 8bp2 by Molmil
2.8A STRUCTURE OF ZOLIFLODACIN WITH S.AUREUS DNA GYRASE AND DNA
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (20-MER), DNA gyrase subunit A, ...
Authors:Bax, B.D, Morgan, H, Warren, A.J.
Deposit date:2022-11-15
Release date:2023-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A 2.8 angstrom Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA Gyrase.
Int J Mol Sci, 24, 2023
4H7W
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BU of 4h7w by Molmil
Crystal Structure of Human C16orf57
Descriptor: CHLORIDE ION, GLYCEROL, UPF0406 protein C16orf57
Authors:Hilcenko, C, Simpson, P.J, Warren, A.J.
Deposit date:2012-09-21
Release date:2013-02-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia.
Blood, 121, 2013
8A3D
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BU of 8a3d by Molmil
Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 28S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Faille, A, Warren, A.J, Dent, K.C.
Deposit date:2022-06-08
Release date:2023-03-08
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (1.67 Å)
Cite:The chemical landscape of the human ribosome at 1.67 angstrom resolution.
Biorxiv, 2023
8B2T
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BU of 8b2t by Molmil
SARS-CoV-2 Main Protease (Mpro) in complex with nirmatrelvir alkyne
Descriptor: 3C-like proteinase nsp5, Nirmatrelvir (reacted form)
Authors:Owen, C.D, Crawshaw, A.D, Warren, A.J, Trincao, J, Zhao, Y, Brewitz, L, Malla, T.R, Salah, E, Petra, L, Strain-Damerell, C, Schofield, C.J, Walsh, M.A.
Deposit date:2022-09-14
Release date:2023-02-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.
J.Med.Chem., 66, 2023
6QKL
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BU of 6qkl by Molmil
Mechanism of eIF6 release from the nascent 60S ribosomal subunit
Descriptor: 26S RIBOSOMAL RNA, 60S acidic ribosomal protein P0, 60S ribosomal protein L10, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-01-29
Release date:2019-03-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of eIF6 release from the nascent 60S ribosomal subunit.
Nat.Struct.Mol.Biol., 22, 2015
6QIK
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BU of 6qik by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-01-20
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6QT0
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BU of 6qt0 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-02-22
Release date:2019-06-26
Last modified:2019-10-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6QTZ
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BU of 6qtz by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-02-26
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6S05
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BU of 6s05 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6RI5
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BU of 6ri5 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S RNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-04-23
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6RZZ
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BU of 6rzz by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
3QRL
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BU of 3qrl by Molmil
Crystal Structure of the Taf14 YEATS domain
Descriptor: TRIETHYLENE GLYCOL, Transcription initiation factor TFIID subunit 14
Authors:Simpson, P.J, Warren, A.J.
Deposit date:2011-02-18
Release date:2012-02-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the Taf14 YEATS domain
To be Published
5ANB
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BU of 5anb by Molmil
Mechanism of eIF6 release from the nascent 60S ribosomal subunit
Descriptor: 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ...
Authors:Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J.
Deposit date:2015-09-06
Release date:2015-10-21
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Nat.Struct.Mol.Biol., 22, 2015
5ANC
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BU of 5anc by Molmil
Mechanism of eIF6 release from the nascent 60S ribosomal subunit
Descriptor: 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ...
Authors:Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J.
Deposit date:2015-09-06
Release date:2015-10-21
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Nat.Struct.Mol.Biol., 22, 2015
5AN9
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BU of 5an9 by Molmil
Mechanism of eIF6 release from the nascent 60S ribosomal subunit
Descriptor: 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ...
Authors:Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J.
Deposit date:2015-09-06
Release date:2015-10-21
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Nat.Struct.Mol.Biol., 22, 2015
2L9N
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BU of 2l9n by Molmil
Structure of the human Shwachman-Bodian-Diamond syndrome (SBDS) protein
Descriptor: Ribosome maturation protein SBDS
Authors:Hilcenko, C, Freund, S.M.V, Warren, A.J.
Deposit date:2011-02-21
Release date:2011-05-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Genes Dev., 25, 2011
2J2S
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BU of 2j2s by Molmil
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase
Descriptor: ZINC FINGER PROTEIN HRX, ZINC ION
Authors:Allen, M.D, Grummitt, C.G, Hilcenko, C, Young-Min, S, Tonkin, L.M, Johnson, C.M, Bycroft, M, Warren, A.J.
Deposit date:2006-08-17
Release date:2006-08-21
Last modified:2017-04-19
Method:SOLUTION NMR
Cite:Solution Structure of the Nonmethyl-Cpg-Binding Cxxc Domain of the Leukaemia-Associated Mll Histone Methyltransferase
Embo J., 25, 2006
1H9D
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BU of 1h9d by Molmil
Aml1/cbf-beta/dna complex
Descriptor: CORE-BINDING FACTOR ALPHA SUBUNIT1, CORE-BINDING FACTOR CBF-BETA, DNA (5'-(*CP*AP*AP*CP*CP*GP*CP*AP*AP*C)-3'), ...
Authors:Bravo, J, Warren, A.J.
Deposit date:2001-03-07
Release date:2001-03-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Leukemia-Associated Aml1 (Runx1)-Cbfbeta Complex Functions as a DNA-Induced Molecular Clamp
Nat.Struct.Biol., 8, 2001

 

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