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3B5W
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CRYSTAL STRUCTURE OF ESCHERICIA COLI MSBA
Descriptor:Lipid A export ATP-binding/permease protein msbA
Authors:Ward, A., Reyes, C.L., Yu, J., Roth, C.B., Chang, G.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5.3 Å)
Cite:Flexibility in the ABC transporter MsbA: Alternating access with a twist.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3B5X
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CRYSTAL STRUCTURE OF MSBA FROM VIBRIO CHOLERAE
Descriptor:Lipid A export ATP-binding/permease protein msbA
Authors:Ward, A., Reyes, C.L., Yu, J., Roth, C.B., Chang, G.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Flexibility in the ABC transporter MsbA: Alternating access with a twist.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3B5Y
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CRYSTAL STRUCTURE OF MSBA FROM SALMONELLA TYPHIMURIUM WITH AMPPNP
Descriptor:Lipid A export ATP-binding/permease protein msbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ward, A., Reyes, C.L., Yu, J., Roth, C.B., Chang, G.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Flexibility in the ABC transporter MsbA: Alternating access with a twist.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3B5Z
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CRYSTAL STRUCTURE OF MSBA FROM SALMONELLA TYPHIMURIUM WITH ADP VANADATE
Descriptor:Lipid A export ATP-binding/permease protein msbA, ADENOSINE-5'-DIPHOSPHATE, VANADATE ION
Authors:Ward, A., Reyes, C.L., Yu, J., Roth, C.B., Chang, G.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Flexibility in the ABC transporter MsbA: Alternating access with a twist.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3B60
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CRYSTAL STRUCTURE OF MSBA FROM SALMONELLA TYPHIMURIUM WITH AMPPNP, HIGHER RESOLUTION FORM
Descriptor:Lipid A export ATP-binding/permease protein msbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ward, A., Reyes, C.L., Yu, J., Roth, C.B., Chang, G.
Deposit date:2007-10-26
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Flexibility in the ABC transporter MsbA: Alternating access with a twist.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Y6C
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THE DISCOVERY OF MMP7 INHIBITORS EXPLOITING A NOVEL SELECTIVITY TRIGGER
Descriptor:MATRILYSIN, CALCIUM ION, ZINC ION, ...
Authors:Edman, K., Furber, M., Hemsley, P., Johansson, C., Pairaudeau, G., Petersen, J., Stocks, M., Tervo, A., Ward, A., Wells, E., Wissler, L.
Deposit date:2011-01-20
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.
Chemmedchem, 6, 2011
2Y6D
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THE DISCOVERY OF MMP7 INHIBITORS EXPLOITING A NOVEL SELECTIVITY TRIGGER
Descriptor:MATRILYSIN, CALCIUM ION, ZINC ION, ...
Authors:Edman, K., Furber, M., Hemsley, P., Johansson, C., Pairaudeau, G., Petersen, J., Stocks, M., Tervo, A., Ward, A., Wells, E., Wissler, L.
Deposit date:2011-01-20
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.
Chemmedchem, 6, 2011
1OG2
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STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9
Descriptor:CYTOCHROME P450 2C9, HEME C
Authors:Williams, P.A., Cosme, J., Ward, A., Angove, H.C., Matak Vinkovic, D., Jhoti, H.
Deposit date:2003-04-23
Release date:2003-07-17
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin
Nature, 424, 2003
1OG5
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STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9
Descriptor:CYTOCHROME P450 2C9, HEME C, S-WARFARIN
Authors:Williams, P.A., Cosme, J., Ward, A., Angove, H.C., Matak Vinkovic, D., Jhoti, H.
Deposit date:2003-04-24
Release date:2003-07-17
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin
Nature, 424, 2003
1W0E
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4
Descriptor:CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
Authors:Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.
Deposit date:2004-06-03
Release date:2004-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
Science, 305, 2004
1W0F
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4
Descriptor:CYTOCHROME P450 3A4, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.
Deposit date:2004-06-03
Release date:2004-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
Science, 305, 2004
1W0G
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4
Descriptor:CYTOCHROME P450 3A4, METYRAPONE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.
Deposit date:2004-06-03
Release date:2004-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
Science, 305, 2004
2XQB
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CRYSTAL STRUCTURE OF ANTI-IL-15 ANTIBODY IN COMPLEX WITH HUMAN IL-15
Descriptor:INTERLEUKIN 15, ANTI-IL-15 ANTIBODY, SULFATE ION
Authors:Lowe, D.C., Gerhardt, S., Ward, A., Hargreaves, D., Anderson, M., StGallay, S., Vousden, K., Ferraro, F., Pauptit, R.A., Cochrane, D., Pattison, D.V., Buchanan, C., Popovic, B., Finch, D.K., Wilkinson, T., Sleeman, M., Vaughan, T.J., Cruwys, S., Mallinder, P.R.
Deposit date:2010-09-01
Release date:2010-12-29
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering a High Affinity Anti-Il-15 Antibody: Crystal Structure Reveals an Alpha-Helix in Vh Cdr3 as Key Component of Paratope.
J.Mol.Biol., 406, 2011
3G5U
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STRUCTURE OF P-GLYCOPROTEIN REVEALS A MOLECULAR BASIS FOR POLY-SPECIFIC DRUG BINDING
Descriptor:Multidrug resistance protein 1a, MERCURY (II) ION
Authors:Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
3G60
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STRUCTURE OF P-GLYCOPROTEIN REVEALS A MOLECULAR BASIS FOR POLY-SPECIFIC DRUG BINDING
Descriptor:Multidrug resistance protein 1a, (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione
Authors:Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
3G61
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STRUCTURE OF P-GLYCOPROTEIN REVEALS A MOLECULAR BASIS FOR POLY-SPECIFIC DRUG BINDING
Descriptor:Multidrug resistance protein 1a, (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione
Authors:Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
Deposit date:2009-02-05
Release date:2009-03-24
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (4.35 Å)
Cite:Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
5AIS
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COMPLEX OF HUMAN HEMATOPOIETIC PROSTAGANDIN D2 SYNTHASE (HH-PGDS) IN COMPLEX WITH AN ACTIVE SITE INHIBITOR.
Descriptor:HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, 4-(dimethylamino)-N-[5-(1H-indol-4-yl)pyridin-3-yl]butanamide, GLUTATHIONE, ...
Authors:Edfeldt, F., Evenas, J., Lepisto, M., Ward, A., Petersen, J., Wissler, L., Rohman, M., Sivars, U., Svensson, K., Perry, M., Feierberg, I., Zhou, X., Hansson, T., Narjes, F.
Deposit date:2015-02-17
Release date:2015-06-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25, 2015
5AIV
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COMPLEX OF HUMAN HEMATOPOIETIC PROSTAGANDIN D2 SYNTHASE (HH-PGDS) IN COMPLEX WITH AN ACTIVE SITE INHIBITOR.
Descriptor:HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, 3-(1H-indol-4-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-5-carboxamide, GLUTATHIONE, ...
Authors:Edfeldt, F., Evenas, J., Lepisto, M., Ward, A., Petersen, J., Wissler, L., Rohman, M., Sivars, U., Svensson, K., Perry, M., Feierberg, I., Zhou, X., Hansson, T., Narjes, F.
Deposit date:2015-02-17
Release date:2015-06-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25, 2015
5AIX
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COMPLEX OF HUMAN HEMATOPOIETIC PROSTAGANDIN D2 SYNTHASE (HH-PGDS) IN COMPLEX WITH AN ACTIVE SITE INHIBITOR.
Descriptor:HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, MAGNESIUM ION, GLUTATHIONE, ...
Authors:Edfeldt, F., Evenas, J., Lepisto, M., Ward, A., Petersen, J., Wissler, L., Rohman, M., Sivars, U., Svensson, K., Perry, M., Feierberg, I., Zhou, X., Hansson, T., Narjes, F.
Deposit date:2015-02-18
Release date:2015-06-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25, 2015
4KSB
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.8001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSC
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSD
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A, R2 protein
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (4.1001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013