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6IUT
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY AVFLUIGG01
Descriptor:AVFluIgG01 Heavy Chain, AVFluIgG01 Light Chain, Hemagglutinin, ...
Authors:Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X.
Deposit date:2018-11-30
Release date:2019-01-16
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
J. Biol. Chem., 294, 2019
6IUV
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY 3C11
Descriptor:Hemagglutinin, 3C11 Light Chain, 3C11 Heavy Chain, ...
Authors:Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X.
Deposit date:2018-11-30
Release date:2019-01-16
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
J. Biol. Chem., 294, 2019
6CKU
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SOLUTION STRUCTURE OF THE ZEBRAFISH GRANULIN AAE
Descriptor:Granulin-AaE
Authors:Wang, P., Ni, F.
Deposit date:2018-02-28
Release date:2018-06-13
Last modified:2018-10-03
Method:SOLUTION NMR
Cite:Structure dissection of zebrafish progranulins identifies a well-folded granulin/epithelin module protein with pro-cell survival activities.
Protein Sci., 27, 2018
4K2X
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OXYS ANHYDROTETRACYCLINE HYDROXYLASE FROM STREPTOMYCES RIMOSUS
Descriptor:Polyketide oxygenase/hydroxylase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Wang, P., Sawaya, M.R., Tang, Y.
Deposit date:2013-04-09
Release date:2013-05-15
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis.
J.Am.Chem.Soc., 135, 2013
4QG6
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CRYSTAL STRUCTURE OF PKM2-Y105E MUTANT
Descriptor:Pyruvate kinase PKM, PROLINE
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.207 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QG8
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CRYSTAL STRUCTURE OF PKM2-K305Q MUTANT
Descriptor:Pyruvate kinase PKM, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QG9
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CRYSTAL STRUCTURE OF PKM2-R399E MUTANT
Descriptor:Pyruvate kinase PKM, MAGNESIUM ION, ACETATE ION
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QGC
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CRYSTAL STRUCTURE OF PKM2-K422R MUTANT
Descriptor:Pyruvate kinase PKM, POTASSIUM ION, SULFATE ION, ...
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.296 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4RPP
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CRYSTAL STRUCTURE OF PKM2-K422R MUTANT BOUND WITH FBP
Descriptor:Pyruvate kinase PKM, BETA-FRUCTOSE-1,6-DIPHOSPHATE
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-10-31
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.585 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4XRU
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STRUCTURE OF PNKP1/RNL/HEN1 COMPLEX
Descriptor:Pnkp1, Rnl, Hen1, ...
Authors:Wang, P.
Deposit date:2015-01-21
Release date:2015-04-22
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complex.
Nat Commun, 6, 2015
5K7M
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAINS OF METTL3/METTL14 COMPLEX
Descriptor:N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14
Authors:Wang, P., Doxtader, K.A., Nam, Y.
Deposit date:2016-05-26
Release date:2016-07-06
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7U
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAINS OF METTL3/METTL14 COMPLEX WITH SAM
Descriptor:N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYLMETHIONINE
Authors:Wang, P., Doxtader, K.A., Nam, Y.
Deposit date:2016-05-26
Release date:2016-07-06
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7W
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF METTL3/METTL14 COMPLEX WITH SAH
Descriptor:N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Wang, P., Doxtader, K.A., Nam, Y.
Deposit date:2016-05-26
Release date:2016-07-06
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5SV7
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THE CRYSTAL STRUCTURE OF A CHAPERONE
Descriptor:Eukaryotic translation initiation factor 2-alpha kinase 3
Authors:Wang, P., Li, J., Sha, B.
Deposit date:2016-08-04
Release date:2017-03-01
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.209 Å)
Cite:The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins.
Acta Crystallogr D Struct Biol, 72, 2016
5U2L
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CRYSTAL STRUCTURE OF THE HSP104 N-TERMINAL DOMAIN FROM CANDIDA ALBICANS
Descriptor:Heat shock protein 104
Authors:Wang, P., Li, J., Sha, B.
Deposit date:2016-11-30
Release date:2017-04-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.6555 Å)
Cite:Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions.
Acta Crystallogr D Struct Biol, 73, 2017
5U2U
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CRYSTAL STRUCTURE OF THE HSP104 N-TERMINAL DOMAIN FROM SACCHAROMYCES CEREVISIAE
Descriptor:Heat shock protein 104
Authors:Wang, P., Li, J., Sha, B.
Deposit date:2016-11-30
Release date:2017-04-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions.
Acta Crystallogr D Struct Biol, 73, 2017
5V1D
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COMPLEX STRUCTURE OF THE BOVINE PERK LUMINAL DOMAIN AND ITS SUBSTRATE PEPTIDE
Descriptor:eIF2AK3 protein, 12-mer peptide
Authors:Wang, P., Li, J., Sha, B.
Deposit date:2017-03-02
Release date:2018-02-14
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization
J. Biol. Chem., 293, 2018
5YUF
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CRYSTAL STRUCTURE OF PML RING TETRAMER
Descriptor:Protein PML, ZINC ION
Authors:Wang, P., Benhend, S., Wu, H., Breitenbach, V., Zhen, T., Jollivet, F., Peres, L., Li, Y., Chen, S., Chen, Z., de THE, H., Meng, G.
Deposit date:2017-11-22
Release date:2018-04-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:RING tetramerization is required for nuclear body biogenesis and PML sumoylation.
Nat Commun, 9, 2018
6A67
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY FLD21.140
Descriptor:FLD21.140 Heavy Chain, FLD21.140 Light Chain, Hemagglutinin, ...
Authors:Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X.
Deposit date:2018-06-26
Release date:2018-08-29
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies.
J. Biol. Chem., 293, 2018
5Z16
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A NOVEL DIMERIC ISOCITRATE DEHYDROGENASE FROM ACINETOBACTER BAUMANNII
Descriptor:Isocitrate dehydrogenase, PHOSPHATE ION, MAGNESIUM ION
Authors:Song, P., Huang, S.P., Wang, P., Zhu, G.P.
Deposit date:2017-12-25
Release date:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:A novel dimeric isocitrate dehydrogenase from Acinetobacter baumannii
To Be Published
4DQZ
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CRYSTAL STRUCTURE OF C-TERMINAL HALF OF BACTERIAL HEN1
Descriptor:Methyltransferase type 12
Authors:Huang, R.H., Wang, P.
Deposit date:2012-02-16
Release date:2012-08-01
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair.
Proc.Natl.Acad.Sci.USA, 109, 2012
4DRF
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CRYSTAL STRUCTURE OF BACTERIAL PNKP-C/HEN1-N HETERODIMER
Descriptor:Metallophosphoesterase, Methyltransferase type 12, GLYCEROL
Authors:Huang, R.H., Wang, P.
Deposit date:2012-02-17
Release date:2012-08-01
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair.
Proc.Natl.Acad.Sci.USA, 109, 2012
4E6N
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CRYSTAL STRUCTURE OF BACTERIAL PNKP-C/HEN1-N HETERODIMER
Descriptor:Metallophosphoesterase, Methyltransferase type 12, MAGNESIUM ION, ...
Authors:Huang, R.H., Wang, P.
Deposit date:2012-03-15
Release date:2012-08-01
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair.
Proc.Natl.Acad.Sci.USA, 109, 2012
4RZY
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CRYSTAL STRUCTURE OF METALLOPEPTIDASE-LIKE DIMETHYLSULPHONIOPROPIONATE (DMSP) LYASE RLDDDP IN COMPLEX WITH MES
Descriptor:Peptidase M24, FE (III) ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Zhang, Y., Wang, P.
Deposit date:2014-12-26
Release date:2015-08-05
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
4RZZ
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CRYSTAL STRUCTURE OF METALLOPEPTIDASE-LIKE DIMETHYLSULPHONIOPROPIONATE (DMSP) LYASE RLDDDP IN COMPLEX WITH PHOSPHATE
Descriptor:Peptidase M24, FE (III) ION, PHOSPHATE ION, ...
Authors:Zhang, Y., Wang, P.
Deposit date:2014-12-27
Release date:2015-08-05
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015