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5GWI
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873R
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.737 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWJ
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873S
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.566 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWK
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HUMAN TOPOISOMERASE IIALPHA IN COMPLEX WITH DNA AND ETOPOSIDE
Descriptor:DNA topoisomerase 2-alpha, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.152 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
2ZED
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT S160A AT 1.7 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-12
Release date:2008-04-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEE
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT S160G AT 1.99 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-12
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEF
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT E201D AT 1.67 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-12
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEG
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT E201L AT 2.08 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ...
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-12
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEH
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT E201Q AT 1.8 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-12
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEL
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT D248A AT 1.97 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-13
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEM
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT D248Q AT 2.18 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-13
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEN
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT D305A AT 1.78 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-13
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEO
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT D305E AT 1.66 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-13
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
2ZEP
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMINYL CYCLASE MUTANT H319L AT 2.1 ANGSTROM RESOLUTION
Descriptor:Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION
Authors:Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Deposit date:2007-12-13
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
5ZEN
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH DNA: A NEW QUATERNARY CONFORMATION SHOWING OPENING OF THE PROTEIN-LINKED DNA-GATE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Chen, S.F., Wang, Y.R., Chan, N.L.
Deposit date:2018-02-27
Release date:2018-08-08
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5ZQF
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5-IODOURIDINE-CONTAINING-DNA IN SPACE GROUP P3221
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-D(P*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ...
Authors:Chen, S.F., Wang, Y.R., Chan, N.L.
Deposit date:2018-04-18
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.873 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5ZRF
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5-IODOURIDINE-CONTAINING-DNA AND ETOPOSIDE IN SPACE GROUP P21
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ...
Authors:Chen, S.F., Wang, Y.R., Wu, C.C., Chan, N.L.
Deposit date:2018-04-24
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
4G0U
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMSACRINE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0V
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND MITOXANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0W
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMETANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4J3N
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2013-02-06
Release date:2013-10-02
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013