Author results

2QCI
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HIV-1 PROTEASE MUTANT D30N WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-19
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
2QD6
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HIV-1 PROTEASE MUTANT I50V WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-20
Release date:2008-04-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
2QD7
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HIV-1 PROTEASE MUTANT V82A WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, PHOSPHATE ION, DIMETHYL SULFOXIDE, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-20
Release date:2008-04-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
2QD8
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HIV-1 PROTEASE MUTANT I84V WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-20
Release date:2008-04-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
2Z4O
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WILD TYPE HIV-1 PROTEASE WITH POTENT ANTIVIRAL INHIBITOR GRL-98065
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2007-06-20
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
3DJK
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WILD TYPE HIV-1 PROTEASE WITH POTENT ANTIVIRAL INHIBITOR GRL-0255A
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Weber, I.T.
Deposit date:2008-06-23
Release date:2008-09-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1 Å)
Cite:Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies
J.Med.Chem., 51, 2008
3DK1
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WILD TYPE HIV-1 PROTEASE WITH POTENT ANTIVIRAL INHIBITOR GRL-0105A
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Wang, Y.F., Weber, I.T.
Deposit date:2008-06-24
Release date:2009-05-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies
Org.Biomol.Chem., 6, 2008
2IEN
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017)
Descriptor:Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Manna, D., Hussain, A.K., Leshchenko, S., Ghosh, A.K., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2006-09-19
Release date:2006-10-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338, 2004
1DAZ
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE (RETROPEPSIN), N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1DW6
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:2000-01-24
Release date:2000-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1EBK
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:2000-01-24
Release date:2000-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1JNP
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CRYSTAL STRUCTURE OF MURINE TCL1 AT 2.5 RESOLUTION
Descriptor:T-CELL LEUKEMIA/LYMPHOMA PROTEIN 1A
Authors:Petock, J.M., Torshin, I.Y., Wang, Y.F., DuBois, G.C., Croce, C.M., Harrison, R.W., Weber, I.T.
Deposit date:2001-07-24
Release date:2001-11-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family.
Acta Crystallogr.,Sect.D, 57, 2001
1TQH
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COVALENT REACTION INTERMEDIATE REVEALED IN CRYSTAL STRUCTURE OF THE GEOBACILLUS STEAROTHERMOPHILUS CARBOXYLESTERASE EST30
Descriptor:Carboxylesterase precursor, SULFATE ION, PROPYL ACETATE
Authors:Liu, P., Wang, Y.F., Ewis, H.E., Abdelal, A.T., Lu, C.D., Harrison, R.W., Weber, I.T.
Deposit date:2004-06-17
Release date:2004-09-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30.
J.Mol.Biol., 342, 2004
2AOC
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT I84V WITH A SUBSTRATE ANALOG P2-NC
Descriptor:HIV-1 PROTEASE, UNKNOWN ATOM OR ION, SODIUM ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOD
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P2-NC
Descriptor:HIV-1 PROTEASE, DIMETHYL SULFOXIDE, UNKNOWN ATOM OR ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOE
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG CA-P2
Descriptor:POL POLYPROTEIN, SODIUM ION, CHLORIDE ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOF
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P1-P6
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, SODIUM ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOG
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P2-NC
Descriptor:HIV-1 PROTEASE (RETROPEPSIN), N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, UNKNOWN ATOM OR ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOH
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P6-PR
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, SODIUM ION, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOI
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P1-P6
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, SULFATE ION
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOJ
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CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P6-PR
Descriptor:POL POLYPROTEIN, PEPTIDE INHIBITOR, DIMETHYL SULFOXIDE, ...
Authors:Tie, Y., Boross, P.I., Wang, Y.F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AVM
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:HIV-1 protease, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVO
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, SULFATE ION, DIMETHYL SULFOXIDE, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVQ
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVS
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, PHOSPHATE ION, SULFATE ION, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
168889
PDB entries from 2020-09-16