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4AOJ
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BU of 4aoj by Molmil
Human TrkA in complex with the inhibitor AZ-23
Descriptor: 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, ZINC ION
Authors:Wang, T, Lamb, M.L, Block, M.H, Davies, A.M, Han, Y, Hoffmann, E, Ioannidis, S, Josey, J.A, Liu, Z, Lyne, P.D, MacIntyre, T, Mohr, P.J, Omer, C.A, Sjogren, T, Thress, K, Wang, B, Wang, H, Yu, D, Zhang, H.
Deposit date:2012-03-28
Release date:2012-08-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors
Acs Med.Chem.Lett., 3, 2012
4FZX
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BU of 4fzx by Molmil
Exonuclease X in complex with 3' overhanging duplex DNA
Descriptor: DNA (5'-D(P*CP*GP*GP*AP*TP*CP*CP*AP*CP*AP*AP*TP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*TP*CP*AP*TP*TP*GP*TP*GP*GP*AP*TP*CP*CP*GP*AP*G)-3'), Exodeoxyribonuclease 10, ...
Authors:Wang, T, Sun, H, Cheng, F, Bi, L, Jiang, T.
Deposit date:2012-07-08
Release date:2013-07-03
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease
Nucleic Acids Res., 41, 2013
4FZY
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BU of 4fzy by Molmil
Exonuclease X in complex with 12bp blunt-ended dsDNA
Descriptor: DNA (5'-D(*TP*GP*TP*AP*GP*AP*TP*TP*CP*GP*AP*G)-3'), DNA (5'-D(P*CP*TP*CP*GP*AP*AP*TP*CP*TP*AP*CP*A)-3'), Exodeoxyribonuclease 10, ...
Authors:Wang, T, Sun, H, Cheng, F, Bi, L, Jiang, T.
Deposit date:2012-07-08
Release date:2013-07-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease
Nucleic Acids Res., 41, 2013
4FZZ
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BU of 4fzz by Molmil
Exonuclease X in complex with 5' overhanging duplex DNA
Descriptor: DNA (5'-D(*GP*TP*CP*AP*TP*TP*GP*TP*GP*GP*AP*TP*CP*CP*GP*AP*G)-3'), Exodeoxyribonuclease 10, SODIUM ION
Authors:Wang, T, Sun, H, Cheng, F, Bi, L, Jiang, T.
Deposit date:2012-07-08
Release date:2013-07-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease
Nucleic Acids Res., 41, 2013
4ZS3
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BU of 4zs3 by Molmil
Structural complex of 5-aminofluorescein bound to the FTO protein
Descriptor: 2-OXOGLUTARIC ACID, 5-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, ...
Authors:Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X.
Deposit date:2015-05-13
Release date:2015-11-04
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
J.Am.Chem.Soc., 137, 2015
4ZS2
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BU of 4zs2 by Molmil
Structural complex of FTO/fluorescein
Descriptor: 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID, 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase FTO, ...
Authors:Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X.
Deposit date:2015-05-13
Release date:2015-11-04
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
J.Am.Chem.Soc., 137, 2015
4EEQ
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BU of 4eeq by Molmil
Crystal structure of E. faecalis DNA ligase with inhibitor
Descriptor: 4-amino-2-(cyclopentyloxy)pyrimidine-5-carboxamide, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, ...
Authors:Wang, T, Charifson, P, Wei, Y.
Deposit date:2012-03-28
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, Synthesis and Activity Evaluation of Potent NAD+ DNA Ligase Inhibitors as Potential Antibacterial Agents.
To be Published
4FPD
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BU of 4fpd by Molmil
Deprotonation of D96 in bacteriorhodopsin opens the proton uptake pathway
Descriptor: 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, CHLORIDE ION, ...
Authors:Wang, T, Sessions, A.O, Lunde, C.S, Rouani, S, Glaeser, R.M, Facciotti, M.T, Duan, Y.
Deposit date:2012-06-22
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Deprotonation of d96 in bacteriorhodopsin opens the proton uptake pathway.
Structure, 21, 2013
3M91
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BU of 3m91 by Molmil
Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa
Descriptor: Prokaryotic ubiquitin-like protein pup, Proteasome-associated ATPase
Authors:Wang, T, Li, H.
Deposit date:2010-03-19
Release date:2010-10-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.
Nat.Struct.Mol.Biol., 17, 2010
3NAO
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BU of 3nao by Molmil
A DNA Crystal Designed to Contain Two Molecules per Asymmetric Unit Cell
Descriptor: DNA (5'-D(*AP*GP*CP*CP*TP*AP*CP*CP*TP*GP*CP*GP*TP*GP*GP*AP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*CP*TP*TP*GP*AP*TP*GP*T)-3'), DNA (5'-D(*GP*AP*GP*CP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), ...
Authors:Wang, T, Sha, R, Birktoft, J.J, Zheng, J, Mao, M, Seeman, N.C.
Deposit date:2010-06-02
Release date:2011-11-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (5.03 Å)
Cite:A DNA crystal designed to contain two molecules per asymmetric unit.
J.Am.Chem.Soc., 132, 2010
1ZMF
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BU of 1zmf by Molmil
C domain of human cyclophilin-33(hcyp33)
Descriptor: Peptidyl-prolyl cis-trans isomerase E
Authors:Wang, T, Yun, C.-H, Gu, S.-Y, Chang, W.-R, Liang, D.-C.
Deposit date:2005-05-10
Release date:2005-08-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:1.88A crystal structure of the C domain of hCyP33: A novel domain of peptidyl-prolyl cis-trans isomerase
Biochem.Biophys.Res.Commun., 333, 2005
2H3B
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BU of 2h3b by Molmil
Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1
Descriptor: Nicotinamide phosphoribosyltransferase, SULFATE ION
Authors:Wang, T, Zhang, X, Bheda, P, Revollo, J.R, Imai, S.I, Wolberger, C.
Deposit date:2006-05-22
Release date:2006-06-20
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme.
Nat.Struct.Mol.Biol., 13, 2006
2H3D
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BU of 2h3d by Molmil
Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide
Descriptor: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, Nicotinamide phosphoribosyltransferase
Authors:Wang, T, Zhang, X, Bheda, P, Revollo, J.R, Imai, S.I, Wolberger, C.
Deposit date:2006-05-22
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme.
Nat.Struct.Mol.Biol., 13, 2006
6KPP
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BU of 6kpp by Molmil
BNC105 in complex with tubulin
Descriptor: (6-methoxy-2-methyl-7-oxidanyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Wang, T, Wu, C, Pu, D.
Deposit date:2019-08-15
Release date:2020-08-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.74524117 Å)
Cite:Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.
Biochem.Biophys.Res.Commun., 2020
2LI6
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BU of 2li6 by Molmil
1H, 13C, and 15N Chemical Shift Assignments for yeast protein
Descriptor: SWI/SNF chromatin-remodeling complex subunit SWI1
Authors:Wang, T, Zhang, J, Tu, X.
Deposit date:2011-08-24
Release date:2012-04-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of SWI1 ARID domain from Saccharomyces cerevisiae and its non-specific binding to DNA
Proteins, 2012
2L7Y
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BU of 2l7y by Molmil
Solution structure of a putative surface protein
Descriptor: Putative endo-beta-N-acetylglucosaminidase
Authors:Wang, T, Yuan, G, Zhang, J, Tu, X.
Deposit date:2010-12-27
Release date:2012-02-29
Last modified:2012-11-21
Method:SOLUTION NMR
Cite:1H and 15N Assigned Chemical Shifts for a putative surface protein
To be Published
7DYG
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BU of 7dyg by Molmil
Histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 2-(1H-pyrazol-3-yl)isonicotinic acid
Descriptor: 2-(1H-pyrazol-3-yl)pyridine-4-carboxylic acid, FE (III) ION, Lysine-specific demethylase 4D
Authors:Wang, T, Yang, L.
Deposit date:2021-01-21
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 2-(1H-pyrazol-3-yl)isonicotinic acid
To Be Published
7DYQ
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BU of 7dyq by Molmil
Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile
Descriptor: 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile, FE (III) ION, Lysine-specific demethylase 4D
Authors:Wang, T, Yang, L.
Deposit date:2021-01-22
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile
To Be Published
4LUQ
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BU of 4luq by Molmil
Crystal structure of virulence effector Tse3 in complex with neutralizer Tsi3
Descriptor: CALCIUM ION, Uncharacterized protein
Authors:Wang, T, Li, L, Zhang, W.
Deposit date:2013-07-25
Release date:2013-09-18
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural Insights on the Bacteriolytic and Self-protection Mechanism of Muramidase Effector Tse3 in Pseudomonas aeruginosa
J.Biol.Chem., 288, 2013
3WA5
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BU of 3wa5 by Molmil
Crystal Structure of type VI peptidoglycan muramidase effector Tse3 in complex with its cognate immunity protein Tsi3
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Tse3-specific immunity protein, ...
Authors:Ding, J, Wang, T, Liu, W, Wang, D.C.
Deposit date:2013-04-26
Release date:2013-10-02
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Complex structure of type VI peptidoglycan muramidase effector and a cognate immunity protein.
Acta Crystallogr.,Sect.D, 69, 2013
5KWA
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BU of 5kwa by Molmil
complete structure of the Mycobacterium tuberculosis proteasomal ATPase Mpa
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Proteasome-associated ATPase
Authors:Wang, T, WU, Y.J.
Deposit date:2016-07-17
Release date:2017-06-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease
Mol. Microbiol., 105, 2017
4DOX
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BU of 4dox by Molmil
Crystal Structure of Papaya mosaic virus capsid protein
Descriptor: Coat protein
Authors:Wang, T, Li, H.
Deposit date:2012-02-11
Release date:2012-06-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the coat protein of the flexible filamentous papaya mosaic virus.
J.Mol.Biol., 422, 2012
4EFE
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BU of 4efe by Molmil
crystal structure of DNA ligase
Descriptor: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, SULFATE ION, ...
Authors:Wei, Y, Wang, T, Charifson, P, Xu, W.
Deposit date:2012-03-29
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:crystal structure of DNA ligase
To be Published
4EFB
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BU of 4efb by Molmil
Crystal structure of DNA ligase
Descriptor: 4-amino-2-(cyclopentyloxy)-6-{[(1R,2S)-2-hydroxycyclopentyl]oxy}pyrimidine-5-carboxamide, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, ...
Authors:Wei, Y, Wang, T, Charifson, P, Xu, W.
Deposit date:2012-03-29
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of DNA ligase
To be Published
4FQB
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BU of 4fqb by Molmil
crystal structure of toxic effector Tse1 in complex with immune protein Tsi1
Descriptor: immune protein Tsi1, toxic effector Tse1
Authors:Wang, T, Li, L, Zhang, W.
Deposit date:2012-06-25
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:structural basis of Tse1 in complex with Tsi1
To be Published

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