Author results

4I9O
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CRYSTAL STRUCTURE OF GACKIX L664C TETHERED TO 1-10
Descriptor:CREB-binding protein, 1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one, 1,2-ETHANEDIOL
Authors:Wang, N., Meagher, J.L., Stuckey, J.A., Mapp, A.K.
Deposit date:2012-12-05
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ordering a dynamic protein via a small-molecule stabilizer.
J.Am.Chem.Soc., 135, 2013
5JI8
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CRYSTAL STRUCTURE OF THE BRD9 BROMODOMAIN AND HIT 1
Descriptor:Bromodomain-containing protein 9, 2-amino-1,3-benzothiazole-6-carboxamide
Authors:Wang, N., Li, F., Bao, H., Li, J., Wu, J., Ruan, K.
Deposit date:2016-04-22
Release date:2016-06-22
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains
Chembiochem, 17, 2016
6A5W
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FXR-LBD WITH HNC143 AND SRC1
Descriptor:Bile acid receptor, Nuclear receptor coactivator 1, 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid
Authors:Wang, N., Liu, J.
Deposit date:2018-06-25
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A5X
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FXR-LBD WITH HNC180 AND SRC1
Descriptor:Bile acid receptor, Nuclear receptor coactivator 1, SULFATE ION, ...
Authors:Wang, N., Liu, J.
Deposit date:2018-06-25
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A5Y
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CRYSTAL STRUCTURE OF HUMAN FXR/RXR-LBD HETERODIMER BOUND TO HNC143 AND 9CRA AND SRC1
Descriptor:Bile acid receptor, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ...
Authors:Wang, N., Liu, J.
Deposit date:2018-06-25
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A5Z
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CRYSTAL STRUCTURE OF HUMAN FXR/RXR-LBD HETERODIMER BOUND TO HNC180 AND 9CRA AND SRC1
Descriptor:Bile acid receptor, Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 1, ...
Authors:Wang, N., Liu, J.
Deposit date:2018-06-25
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A60
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CRYSTAL STRUCTURE OF HUMAN FXR/RXR-LBD HETERODIMER BOUND TO GW4064 AND 9CRA AND SRC1
Descriptor:Bile acid receptor, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ...
Authors:Wang, N., Liu, J.
Deposit date:2018-06-25
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6J4O
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STRUCTURAL BASIS OF TUBULIN DETYROSINATION BY VASOHIBINS-SVBP ENZYME COMPLEX AND FUNCTIONAL IMPLICATIONS
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, GLYCEROL, ...
Authors:Wang, N., Huang, H.
Deposit date:2019-01-10
Release date:2019-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
To Be Published
6J4P
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STRUCTURAL BASIS OF TUBULIN DETYROSINATION BY VASOHIBINS-SVBP ENZYME COMPLEX AND FUNCTIONAL IMPLICATIONS
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-tyrosine
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-01-10
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
To Be Published
6J4Q
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STRUCTURAL BASIS OF TUBULIN DETYROSINATION BY VASOHIBINS-SVBP ENZYME COMPLEX AND FUNCTIONAL IMPLICATIONS
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide, ...
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-01-10
Release date:2019-05-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
To Be Published
6J4S
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STRUCTURAL BASIS OF TUBULIN DETYROSINATION BY VASOHIBINS-SVBP ENZYME COMPLEX AND FUNCTIONAL IMPLICATIONS
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, GLYCEROL, ...
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-01-10
Release date:2019-05-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
To Be Published
6J4U
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STRUCTURAL BASIS OF TUBULIN DETYROSINATION BY VASOHIBINS-SVBP ENZYME COMPLEX AND FUNCTIONAL IMPLICATIONS
Descriptor:Tubulinyl-Tyr carboxypeptidase 1, Small vasohibin-binding protein
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-01-10
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
To Be Published
6J4V
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STRUCTURAL BASIS OF TUBULIN DETYROSINATION BY VASOHIBINS-SVBP ENZYME COMPLEX AND FUNCTIONAL IMPLICATIONS
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, Alpha-tubulin tail E450C, ...
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-01-10
Release date:2019-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
To Be Published
6KBS
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CRYSTAL STRUCTURE OF YEDK IN COMPLEX WITH SSDNA
Descriptor:SOS response-associated protein, DNA (5'-D(*CP*GP*GP*TP*CP*GP*AP*TP*TP*C)-3')
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Crystal structure of yedK in complex with ssDNA
To Be Published
6KBU
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CRYSTAL STRUCTURE OF YEDK
Descriptor:SOS response-associated protein, GLYCEROL
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of yedK
To Be Published
6KBX
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CRYSTAL STRUCTURE OF YEDK IN COMPLEX WITH SSDNA CONTAINING ABASIC SITE
Descriptor:SOS response-associated protein, DNA 5'-D (*CP*GP*GP*TP* (PED)P*GP*AP*TP*TP*C)-3'
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.221 Å)
Cite:Crystal structure of yedK in complex with ssDNA containing abasic site
To Be Published
6KBZ
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CRYSTAL STRUCTURE OF YEDK WITH SSDNA CONTAINING A TETRAHYDROFURAN ABASIC SITE
Descriptor:SOS response-associated protein, 5'-D (*CP*GP*GP*TP* (3DR) P*GP*AP*TP*TP*C)-3', MAGNESIUM ION
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.653 Å)
Cite:Crystal structure of yedK
To Be Published
6KCQ
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CRYSTAL STRUCTURE OF YEDK WITH SSDNA CONTAINING AN ABASIC SITE
Descriptor:SOS response-associated protein, DNA (5'-D(P*AP*AP*AP*(PED)P*AP*A)-3')
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Crystal structure of yedK
To Be Published
6KIJ
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CRYSTAL STRUCTURE OF YEDK WITH SSDNA CONTAINING AN ABASIC SITE
Descriptor:SOS response-associated protein, DNA (5'-D(*GP*AP*TP*TP*CP*GP*TP*CP*G)-3'), PENTANE-3,4-DIOL-5-PHOSPHATE, ...
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-07-18
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of yedK
To Be Published
6C6Z
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CRYSTAL STRUCTURE OF POTENT NEUTRALIZING ANTIBODY CDC2-C2 IN COMPLEX WITH MERS-COV S1 RBD
Descriptor:Spike protein, Antibody CDC2-C2 heavy chain, Antibody CDC2-C2 light chain, ...
Authors:Wang, N., McLellan, J.S.
Deposit date:2018-01-19
Release date:2018-01-31
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
J. Virol., 92, 2018
5VYH
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CRYSTAL STRUCTURE OF MERS-COV S1 N-TERMINAL DOMAIN
Descriptor:S protein, N-ACETYL-D-GLUCOSAMINE, FOLIC ACID, ...
Authors:Wang, N., Wrapp, D., Pallesen, J., Ward, A.B., McLellan, J.S.
Deposit date:2017-05-25
Release date:2017-08-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VZR
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CRYSTAL STRUCTURE OF MERS-COV NEUTRALIZING ANTIBODY G4 FAB
Descriptor:G4 antibody heavy chain, G4 antibody light chain, GLYCEROL
Authors:Wang, N., Wrapp, D., McLellan, J.S.
Deposit date:2017-05-29
Release date:2017-08-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6J7B
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CRYSTAL STRUCTURE OF VASH1-SVBP IN COMPLEX WITH EPOY
Descriptor:Tubulinyl-Tyr carboxypeptidase 1, Small vasohibin-binding protein, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-tyrosine
Authors:Wang, N., Bao, H., Huang, H., Wu, B.
Deposit date:2019-01-17
Release date:2019-06-19
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.618 Å)
Cite:Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Cell Res., 29, 2019
5ZAP
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ATOMIC STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 2 B-CAPSID
Descriptor:Major capsid protein, Triplex capsid protein 2, Triplex capsid protein 1, ...
Authors:Yuan, S., Wang, J.L., Zhu, D.J., Wang, N., Gao, Q., Chen, W.Y., Tang, H., Wang, J.Z., Zhang, X.Z., Liu, H.R., Rao, Z.H., Wang, X.X.
Deposit date:2018-02-08
Release date:2018-04-18
Last modified:2018-09-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of a herpesvirus capsid at 3.1 angstrom.
Science, 360, 2018
5ZZ8
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STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 2 C-CAPSID WITH CAPSID-VERTEX-SPECIFIC COMPONENT
Descriptor:VP19C, VP23, Major capsid protein, ...
Authors:Wang, J.L., Yuan, S., Zhu, D.J., Tang, H., Wang, N., Chen, W.Y., Gao, Q., Li, Y.H., Wang, J.Z., Liu, H.R., Zhang, X.Z., Rao, Z.H., Wang, X.X.
Deposit date:2018-05-31
Release date:2018-10-10
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component.
Nat Commun, 9, 2018