6JJP | | CRYSTAL STRUCTURE OF FAB OF A PD-1 MONOCLONAL ANTIBODY MW11-H317 IN COMPLEX WITH PD-1 | | Descriptor: | Heavy chain of MW11-h317, light chain of MW11-h317, Programmed cell death protein 1, ... | | Authors: | Wang, M., Wang, J., Wang, R., Jiao, S., Wang, S., Zhang, J., Zhang, M. | | Deposit date: | 2019-02-26 | | Release date: | 2019-10-30 | | Last modified: | 2019-11-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation.
Commun Biol, 2, 2019
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2FXY | |
2FXZ | |
2KQ3 | | SOLUTION STRUCTURE OF SNASE140 | | Descriptor: | Thermonuclease | | Authors: | Wang, M., Feng, Y., Yao, H., Wang, J. | | Deposit date: | 2009-10-26 | | Release date: | 2010-05-26 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Importance of the C-Terminal Loop L137-S141 for the Folding and Folding Stability of Staphylococcal Nuclease
Biochemistry, 49, 2010
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3NCI | | RB69 DNA POLYMERASE TERNARY COMPLEX WITH DCTP OPPOSITE DG AT 1.8 ANGSTROM RESOLUTION | | Descriptor: | DNA polymerase, DNA (5'-D(*TP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | Authors: | Wang, M., Blaha, G., Steitz, T.A., Konigsberg, W.H., Wang, J. | | Deposit date: | 2010-06-04 | | Release date: | 2011-02-02 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Insights into base selectivity from the 1.8 A resolution structure of an RB69 DNA polymerase ternary complex.
Biochemistry, 50, 2011
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4QY0 | | STRUCTURE OF H10 FROM HUMAN-INFECTING H10N8 | | Descriptor: | hemagglutinin, N-ACETYL-D-GLUCOSAMINE | | Authors: | Wang, M., Zhang, W., Qi, J., Wang, F., Zhou, J., Bi, Y., Wu, Y., Sun, H., Liu, J., Huang, C., Li, X., Yan, J., Shu, Y., Shi, Y., Gao, G.F. | | Deposit date: | 2014-07-23 | | Release date: | 2015-01-28 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus
Nat Commun, 6, 2015
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4QY1 | | STRUCTURE OF H10 FROM HUMAN-INFECTING H10N8 IN COMPLEX WITH AVIAN RECEPTOR | | Descriptor: | hemagglutinin, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ... | | Authors: | Wang, M., Zhang, W., Qi, J., Wang, F., Zhou, J., Bi, Y., Wu, Y., Sun, H., Liu, J., Huang, C., Li, X., Yan, J., Shu, Y., Shi, Y., Gao, G.F. | | Deposit date: | 2014-07-23 | | Release date: | 2015-01-28 | | Method: | X-RAY DIFFRACTION (2.594 Å) | | Cite: | Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus
Nat Commun, 6, 2015
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4QY2 | | STRUCTURE OF H10 FROM HUMAN-INFECTING H10N8 VIRUS IN COMPLEX WITH HUMAN RECEPTOR ANALOG | | Descriptor: | hemagglutinin, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID | | Authors: | Wang, M., Zhang, W., Qi, J., Wang, F., Zhou, J., Bi, Y., Wu, Y., Sun, H., Liu, J., Huang, C., Li, X., Yan, J., Shu, Y., Shi, Y., Gao, G.F. | | Deposit date: | 2014-07-23 | | Release date: | 2015-01-28 | | Method: | X-RAY DIFFRACTION (2.399 Å) | | Cite: | Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus
Nat Commun, 6, 2015
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4X1B | | HUMAN SERUM TRANSFERRIN WITH FERRIC ION BOUND AT THE C-LOBE ONLY | | Descriptor: | Serotransferrin, FE (III) ION, MALONATE ION, ... | | Authors: | Wang, M., Zhang, H., Sun, H. | | Deposit date: | 2014-11-24 | | Release date: | 2015-04-08 | | Last modified: | 2015-05-06 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | "Anion clamp" allows flexible protein to impose coordination geometry on metal ions
Chem.Commun.(Camb.), 51, 2015
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4X1D | | YTTERBIUM-BOUND HUMAN SERUM TRANSFERRIN | | Descriptor: | Serotransferrin, YTTERBIUM (III) ION, MALONATE ION, ... | | Authors: | Wang, M., Zhang, H., Sun, H. | | Deposit date: | 2014-11-24 | | Release date: | 2015-04-08 | | Last modified: | 2015-05-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | "Anion clamp" allows flexible protein to impose coordination geometry on metal ions
Chem.Commun.(Camb.), 51, 2015
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5ZQY | | CRYSTAL STRUCTURE OF A POLY(ADP-RIBOSE) GLYCOHYDROLASE | | Descriptor: | Poly(ADP-ribose) glycohydrolase ARH3, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Wang, M., Yuan, Z., Ma, Y., Wang, J., Liu, X. | | Deposit date: | 2018-04-20 | | Release date: | 2018-08-15 | | Last modified: | 2018-09-26 | | Method: | X-RAY DIFFRACTION (1.577 Å) | | Cite: | Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation.
J. Biol. Chem., 293, 2018
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2KJ4 | | SOLUTION STRUCTURE OF THE COMPLEX OF VEK-30 AND PLASMINOGEN KRINGLE 2 | | Descriptor: | plasminogen, VEK-30 | | Authors: | Wang, M., Zajicek, J., Prorok, M., Castellin, F.J. | | Deposit date: | 2009-05-21 | | Release date: | 2009-10-20 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the complex of VEK-30 and plasminogen kringle 2.
J.Struct.Biol., 169, 2010
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1AMO | | THREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMES | | Descriptor: | NADPH-CYTOCHROME P450 REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S.S., Kim, J.J.P. | | Deposit date: | 1997-06-17 | | Release date: | 1998-06-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.
Proc.Natl.Acad.Sci.USA, 94, 1997
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1NHU | | HEPATITIS C VIRUS RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR | | Descriptor: | HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-BENZYL)-AMINO]-3-PHENYL-PROPIONIC ACID | | Authors: | Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G. | | Deposit date: | 2002-12-19 | | Release date: | 2003-03-18 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on
HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
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1NHV | | HEPATITIS C VIRUS RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR | | Descriptor: | HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID | | Authors: | Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G. | | Deposit date: | 2002-12-19 | | Release date: | 2003-03-18 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on
HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
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2F48 | |
5EQJ | | CRYSTAL STRUCTURE OF THE TWO-SUBUNIT TRNA M1A58 METHYLTRANSFERASE FROM SACCHAROMYCES CEREVISIAE | | Descriptor: | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 | | Authors: | Zhu, Y., Wang, M., Wang, C., Fan, X., Jiang, X., Teng, M., Li, X. | | Deposit date: | 2015-11-13 | | Release date: | 2016-09-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Sci Rep, 6, 2016
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5ERG | | CRYSTAL STRUCTURE OF THE TWO-SUBUNIT TRNA M1A58 METHYLTRANSFERASE TRM6-TRM61 IN COMPLEX WITH SAM | | Descriptor: | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, S-ADENOSYLMETHIONINE | | Authors: | Zhu, Y., Wang, M., Wang, C., Fan, X., Jiang, X., Teng, M., Li, X. | | Deposit date: | 2015-11-14 | | Release date: | 2016-09-14 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Sci Rep, 6, 2016
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2PL5 | | CRYSTAL STRUCTURE OF HOMOSERINE O-ACETYLTRANSFERASE FROM LEPTOSPIRA INTERROGANS | | Descriptor: | Homoserine O-acetyltransferase, GLYCEROL | | Authors: | Liu, L., Wang, M., Wang, Y., Wei, Z., Xu, H., Gong, W. | | Deposit date: | 2007-04-19 | | Release date: | 2007-11-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of homoserine O-acetyltransferase from Leptospira interrogans
Biochem.Biophys.Res.Commun., 363, 2007
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3LZI | | RB69 DNA POLYMERASE (Y567A) TERNARY COMPLEX WITH DATP OPPOSITE 7,8-DIHYDRO-8-OXOGUANINE | | Descriptor: | DNA polymerase, DNA (5'-D(P*TP*CP*AP*(8OG)P*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | Authors: | Wang, M., Beckman, J., Blaha, G., Wang, J., Konigsberg, W.H. | | Deposit date: | 2010-03-01 | | Release date: | 2010-05-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine .
Biochemistry, 49, 2010
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3LZJ | | RB69 DNA POLYMERASE (Y567A) TERNARY COMPLEX WITH DCTP OPPOSITE 7,8-DIHYDRO-8-OXOGUANINE | | Descriptor: | DNA polymerase, DNA (5'-D(P*TP*CP*AP*(8OG)P*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | Authors: | Wang, M., Beckman, J., Blaha, G., Wang, J., Konigsberg, W.H. | | Deposit date: | 2010-03-01 | | Release date: | 2010-05-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine .
Biochemistry, 49, 2010
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3NAE | | RB69 DNA POLYMERASE (Y567A) TERNARY COMPLEX WITH DATP OPPOSITE GUANIDINOHYDANTOIN | | Descriptor: | DNA polymerase, DNA (5'-D(*TP*CP*AP*(G35)P*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | Authors: | Wang, M., Beckman, J., Blaha, G., Wang, J., Konigsberg, W.H. | | Deposit date: | 2010-06-01 | | Release date: | 2010-09-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.003 Å) | | Cite: | Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin .
Biochemistry, 49, 2010
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3NDK | | RB69 DNA POLYMERASE (Y567A) TERNARY COMPLEX WITH DCTP OPPOSITE DG | | Descriptor: | DNA polymerase, DNA (5'-D(*TP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | Authors: | Wang, M., Wang, J., Konigsberg, W.H. | | Deposit date: | 2010-06-07 | | Release date: | 2011-01-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures.
J.Mol.Biol., 406, 2011
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3NE6 | | RB69 DNA POLYMERASE (S565G/Y567A) TERNARY COMPLEX WITH DCTP OPPOSITE DG | | Descriptor: | DNA polymerase, DNA (5'-D(*TP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | Authors: | Wang, M., Wang, J., Konigsberg, W.H. | | Deposit date: | 2010-06-08 | | Release date: | 2011-01-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures.
J.Mol.Biol., 406, 2011
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3NGI | | RB69 DNA POLYMERASE (Y567A) TERNARY COMPLEX WITH DTTP OPPOSITE DG | | Descriptor: | DNA polymerase, DNA (5'-D(*TP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | Authors: | Wang, M., Wang, J., Konigsberg, W.H. | | Deposit date: | 2010-06-11 | | Release date: | 2011-01-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.886 Å) | | Cite: | Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures.
J.Mol.Biol., 406, 2011
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