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3H98
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CRYSTAL STRUCTURE OF HCV NS5B 1B WITH (1,1-DIOXO-2H-[1,2,4]BENZOTHIADIAZIN-3-YL) AZOLO[1,5-A]PYRIMIDINE DERIVATIVE
Descriptor:RNA-directed RNA polymerase, N-{3-[5-hydroxy-8-(3-methylbutyl)-7-oxo-7,8-dihydroimidazo[1,2-a]pyrimidin-6-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, GLYCEROL
Authors:Wang, G., Lei, H., Wang, X., Das, D., Mackinnon, C., Montalbetti, C.A.G., Mears, R., Gai, X., Bailey, S., Ruhrmund, D., Hooi, L., Misialek, S., Rajagopalan, R., Cheng, R.K.Y., Barker, J.L., Felicetti, B., Stoycheva, A., Buckman, B., Kossen, K., Seiwert, S., Beigelmana, L.
Deposit date:2009-04-30
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
Bioorg.Med.Chem.Lett., 19, 2009
1BYM
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SOLUTION STRUCTURES OF THE C-TERMINAL DOMAIN OF DIPHTHERIA TOXIN REPRESSOR
Descriptor:PROTEIN (DIPHTHERIA TOXIN REPRESSOR)
Authors:Wang, G., Wylie, G.P., Twigg, P.D., Caspar, D.L.D., Murphy, J.R., Logan, T.M.
Deposit date:1998-10-17
Release date:1998-10-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and peptide binding studies of the C-terminal src homology 3-like domain of the diphtheria toxin repressor protein.
Proc.Natl.Acad.Sci.USA, 96, 1999
1GW3
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THE HELIX-HINGE-HELIX STRUCTURAL MOTIF IN HUMAN APOLIPOPROTEIN A-I DETERMINED BY NMR SPECTROSCOPY, 1 STRUCTURE
Descriptor:APOA-I
Authors:Wang, G., Sparrow, J.T., Cushley, R.J.
Deposit date:1997-06-04
Release date:1997-07-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The helix-hinge-helix structural motif in human apolipoprotein A-I determined by NMR spectroscopy.
Biochemistry, 36, 1997
1GW4
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THE HELIX-HINGE-HELIX STRUCTURAL MOTIF IN HUMAN APOLIPOPROTEIN A-I DETERMINED BY NMR SPECTROSCOPY, 1 STRUCTURE
Descriptor:APOA-I
Authors:Wang, G., Sparrow, J.T., Cushley, R.J.
Deposit date:1997-06-04
Release date:1997-07-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The helix-hinge-helix structural motif in human apolipoprotein A-I determined by NMR spectroscopy.
Biochemistry, 36, 1997
1NH9
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CRYSTAL STRUCTURE OF A DNA BINDING PROTEIN MJA10B FROM THE HYPERTHERMOPHILE METHANOCOCCUS JANNASCHII
Descriptor:DNA-binding protein Alba
Authors:Wang, G., Bartlam, M., Guo, R., Yang, H., Xue, H., Liu, Y., Huang, L., Rao, Z.
Deposit date:2002-12-19
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a DNA binding protein from the hyperthermophilic euryarchaeon Methanococcus jannaschii
Protein Sci., 12, 2003
1O53
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SOLUTION STRUCTURE OF THE N-TERMINAL MEMBRANE ANCHOR OF E. COLI ENZYME IIA(GLUCOSE)
Descriptor:PTS system, glucose-specific IIA component
Authors:Wang, G., Keifer, P.A., Peterkofsky, A.
Deposit date:2003-08-11
Release date:2003-08-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the N-terminal amphitropic domain of Escherichia coli glucose-specific enzyme IIA in membrane-mimetic micelles
Protein Sci., 12, 2003
1ODP
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PEPTIDE OF HUMAN APOA-I RESIDUES 166-185. NMR, 5 STRUCTURES AT PH 6.6, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:40
Descriptor:APOA-I PEPTIDE
Authors:Wang, G., Treleaven, W.D., Cushley, R.J.
Deposit date:1996-03-02
Release date:1996-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions.
Biochim.Biophys.Acta, 1301, 1996
1ODQ
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PEPTIDE OF HUMAN APOA-I RESIDUES 166-185. NMR, 5 STRUCTURES AT PH 3.7, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:40
Descriptor:APOA-I PEPTIDE
Authors:Wang, G., Treleaven, W.D., Cushley, R.J.
Deposit date:1996-03-02
Release date:1996-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions.
Biochim.Biophys.Acta, 1301, 1996
1ODR
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PEPTIDE OF HUMAN APOA-I RESIDUES 166-185. NMR, 5 STRUCTURES AT PH 6.0, 37 DEGREES CELSIUS AND PEPTIDE:DPC MOLE RATIO OF 1:40
Descriptor:APOA-I PEPTIDE
Authors:Wang, G., Treleaven, W.D., Cushley, R.J.
Deposit date:1996-03-02
Release date:1996-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions.
Biochim.Biophys.Acta, 1301, 1996
1OEF
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PEPTIDE OF HUMAN APOE RESIDUES 263-286, NMR, 5 STRUCTURES AT PH 4.8, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:90
Descriptor:APOLIPOPROTEIN E
Authors:Wang, G., Pierens, G.K., Treleaven, W.D., Sparrow, J.T., Cushley, R.J.
Deposit date:1996-03-16
Release date:1996-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformations of human apolipoprotein E(263-286) and E(267-289) in aqueous solutions of sodium dodecyl sulfate by CD and 1H NMR.
Biochemistry, 35, 1996
1OEG
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PEPTIDE OF HUMAN APOE RESIDUES 267-289, NMR, 5 STRUCTURES AT PH 6.0, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:90
Descriptor:APOLIPOPROTEIN E
Authors:Wang, G., Pierens, G.K., Treleaven, W.D., Sparrow, J.T., Cushley, R.J.
Deposit date:1996-03-16
Release date:1996-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformations of human apolipoprotein E(263-286) and E(267-289) in aqueous solutions of sodium dodecyl sulfate by CD and 1H NMR.
Biochemistry, 35, 1996
1VM2
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SOLUTION STRUCTURE OF AN ANTICANCER PEPTIDE DESIGNED BASED ON THE N-TERMINAL SEQUENCE OF E. COLI ENZYME IIA (GLUCOSE)
Descriptor:peptide A2
Authors:Wang, G., Li, X.
Deposit date:2004-08-31
Release date:2004-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Correlation of Three-dimensional Structures with the Antibacterial Activity of a Group of Peptides Designed Based on a Nontoxic Bacterial Membrane Anchor.
J.Biol.Chem., 280, 2005
1VM3
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SOLUTION STRUCTURE OF A MEMBRANE-TARGETING PEPTIDE DESIGNED BASED ON THE N-TERMINAL SEQUENCE OF E. COLI ENZYME IIA (GLUCOSE)
Descriptor:peptide A3
Authors:Wang, G., Li, X.
Deposit date:2004-08-31
Release date:2004-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Correlation of Three-dimensional Structures with the Antibacterial Activity of a Group of Peptides Designed Based on a Nontoxic Bacterial Membrane Anchor.
J.Biol.Chem., 280, 2005
1VM4
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SOLUTION STRUCTURE OF AN ANTIBACTERIAL AND ANTITUMOR PEPTIDE DESIGNED BASED ON THE N-TERMINAL MEMBRANE ANCHOR OF E. COLI ENZYME IIA (GLUCOSE)
Descriptor:peptide A4
Authors:Wang, G., Li, X.
Deposit date:2004-08-31
Release date:2004-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Correlation of Three-dimensional Structures with the Antibacterial Activity of a Group of Peptides Designed Based on a Nontoxic Bacterial Membrane Anchor.
J.Biol.Chem., 280, 2005
1VM5
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SOLUTION STRUCTURE OF MICELLE-BOUND AUREIN 1.2, AN ANTIMICROBIAL AND ANTICANCER PEPTIDE FROM AN AUSTRALIAN FROG
Descriptor:peptide A5 or aurein 1.2
Authors:Wang, G., Li, X.
Deposit date:2004-08-31
Release date:2004-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Correlation of Three-dimensional Structures with the Antibacterial Activity of a Group of Peptides Designed Based on a Nontoxic Bacterial Membrane Anchor.
J.Biol.Chem., 280, 2005
2K6O
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HUMAN LL-37 STRUCTURE
Descriptor:Cathelicidin antimicrobial peptide
Authors:Wang, G.
Deposit date:2008-07-14
Release date:2008-09-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles
J.Biol.Chem., 283, 2008
2L5M
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SOLUTION STRUCTURE OF GF-17 IN COMPLEX WITH MICELLES
Descriptor:GF-17
Authors:Wang, G.
Deposit date:2010-11-02
Release date:2011-11-02
Last modified:2012-02-29
Method:SOLUTION NMR
Cite:Decoding the Functional Roles of Cationic Side Chains of the Major Antimicrobial Region of Human Cathelicidin LL-37.
Antimicrob.Agents Chemother., 56, 2012
2LMF
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SOLUTION STRUCTURE OF HUMAN LL-23 BOUND TO MEMBRANE-MIMETIC MICELLES
Descriptor:Antibacterial protein LL-37
Authors:Wang, G.
Deposit date:2011-11-30
Release date:2011-12-28
Last modified:2012-02-08
Method:SOLUTION NMR
Cite:Structure, Dynamics, and Antimicrobial and Immune Modulatory Activities of Human LL-23 and Its Single-Residue Variants Mutated on the Basis of Homologous Primate Cathelicidins.
Biochemistry, 51, 2012
3BGW
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THE STRUCTURE OF A DNAB-LIKE REPLICATIVE HELICASE AND ITS INTERACTIONS WITH PRIMASE
Descriptor:DNAB-Like Replicative Helicase
Authors:Wang, G., Klein, M.G., Tokonzaba, E., Zhang, Y., Holden, L.G., Chen, X.S.
Deposit date:2007-11-27
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.91 Å)
Cite:The structure of a DnaB-family replicative helicase and its interactions with primase.
Nat.Struct.Mol.Biol., 15, 2008
3BH0
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ATPASE DOMAIN OF G40P
Descriptor:DNAB-LIKE REPLICATIVE HELICASE
Authors:Wang, G., Klein, M.G., Tokonzaba, E., Zhang, Y., Holden, L.G., Chen, X.S.
Deposit date:2007-11-27
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structure of a DnaB-family replicative helicase and its interactions with primase.
Nat.Struct.Mol.Biol., 15, 2008
4QKB
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CRYSTAL STRUCTURE OF SELENO-METHIONINE LABELLED HUMAN ALKBH7 IN COMPLEX WITH ALPHA-KETOGLUTARATE AND MN(II)
Descriptor:Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial, MANGANESE (II) ION, ...
Authors:Wang, G., He, Q., Chen, Z.
Deposit date:2014-06-05
Release date:2014-08-20
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism
J.Biol.Chem., 289, 2014
4QKD
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CRYSTAL STRUCTURE OF HUMAN ALKBH7 IN COMPLEX WITH ALPHA-KETOGLUTARATE AND MN(II)
Descriptor:Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial, MANGANESE (II) ION, ...
Authors:Wang, G., Chen, Z.
Deposit date:2014-06-06
Release date:2014-08-20
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism
J.Biol.Chem., 289, 2014
4QKF
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CRYSTAL STRUCTURE OF HUMAN ALKBH7 IN COMPLEX WITH N-OXALYLGLYCINE AND MN(II)
Descriptor:Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial, MANGANESE (II) ION, ...
Authors:Wang, G., Chen, Z.
Deposit date:2014-06-06
Release date:2014-08-20
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism
J.Biol.Chem., 289, 2014
4Z09
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CRYSTAL STRUCTURE OF FVO STRAIN PLASMODIUM FALCIPARUM AMA1 IN COMPLEX WITH THE RON2HP [THR2040ALA] PEPTIDE
Descriptor:Apical membrane antigen 1, Rhoptry neck protein 2, GLYCEROL
Authors:Wang, G., McGowan, S., Norton, R.S., Scanlon, M.J.
Deposit date:2015-03-26
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.
J.Mol.Biol., 428, 2016
4Z0D
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CRYSTAL STRUCTURE OF FVO STRAIN PLASMODIUM FALCIPARUM AMA1 IN COMPLEX WITH THE RON2HP [PHE2038TRP] PEPTIDE
Descriptor:Apical membrane antigen 1, Rhoptry neck protein 2
Authors:Wang, G., McGowan, S., Norton, R.S., Scanlon, M.J.
Deposit date:2015-03-26
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.
J.Mol.Biol., 428, 2016