Author results

3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, PHENOL, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
1Q4V
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CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR
分子名称:Insulin, ZINC ION, PHENOL
著者Wan, Z.L., Xu, B., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
登録日2003-08-04
公開日2003-08-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Biochemistry, 42, 2003
1XW7
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DIABETES-ASSOCIATED MUTATIONS IN HUMAN INSULIN: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING STUDIES OF A-CHAIN VARIANT INSULIN WAKAYAMA
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Wan, Z.L., Huang, K., Xu, B., Chu, Y.C., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
登録日2004-10-29
公開日2005-04-12
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama
Biochemistry, 44, 2005
2L1Y
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
分子名称:Insulin A chain, Insulin B chain
著者Wan, Z.L., Hua, Q.X., Huang, K., Hu, S.Q., Philips, N.B., Katsoyannis, J.W., Weiss, M.A.
登録日2010-08-09
公開日2011-08-31
実験手法SOLUTION NMR
主引用文献Chiral Protein Engineering and its Application in G Health
To be Published
2L1Z
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
分子名称:Insulin A chain, Insulin B chain
著者Wan, Z.L., Hua, Q.X., Huang, K., Hu, S.Q., Philips, N.B., Katsoyannis, J.W., Weiss, M.A.
登録日2010-08-09
公開日2011-08-31
実験手法SOLUTION NMR
主引用文献Chiral Protein Engineering and its Application in G Health
To be Published
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
登録日2009-11-17
公開日2010-02-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2011-04-26
公開日2012-05-02
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
2KQQ
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-D-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
分子名称:Insulin B chain, Insulin A chain
著者Hua, Q.X., Wan, Z.L., Zhao, M., Jia, W., Huang, K., Weiss, M.A.
登録日2009-11-13
公開日2010-11-24
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog.
To be Published
3FQ9
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DESIGN OF AN INSULIN ANALOG WITH ENHANCED RECEPTOR-BINDING SELECTIVITY. RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
分子名称:Insulin, ZINC ION
著者Zhao, M., Wan, Z.L., Whittaker, L., Xu, B., Phillips, N., Katsoyannis, P., Whittaker, J., Weiss, M.A.
登録日2009-01-07
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
登録日2009-03-11
公開日2009-03-24
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2009-09-10
公開日2010-09-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
分子名称:insulin A chain, insulin B chain, ZINC ION
著者Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
登録日2008-01-14
公開日2008-05-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
1RWE
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ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
分子名称:insulin, Insulin, ZINC ION, ...
著者Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
登録日2003-12-16
公開日2005-02-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
1LIA
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CRYSTAL STRUCTURE OF R-PHYCOERYTHRIN FROM POLYSIPHONIA AT 2.8 A RESOLUTION
分子名称:R-PHYCOERYTHRIN, PHYCOCYANOBILIN, PHYCOUROBILIN
著者Liang, D.C., Jiang, T., Chang, W.R.
登録日1996-01-29
公開日1997-07-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of R-phycoerythrin from Polysiphonia urceolata at 2.8 A resolution.
J.Mol.Biol., 262, 1996
4P65
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CRYSTAL STRUCTURE OF AN CYCLOHEXYLALANINE SUBSTITUTED INSULIN ANALOG.
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Pandyarajan, V., Wan, Z., Weiss, M.A.
登録日2014-03-21
公開日2014-10-22
最終更新日2014-12-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
1SDB
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PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN
分子名称:DESB1-2 DESPENTAPEPTIDE (B26-B30) INSULIN
著者Liang, D.-C., Diao, J.-S.
登録日1996-01-29
公開日1997-02-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution.
Acta Crystallogr.,Sect.D, 53, 1997
2MLI
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NMR STRUCTURE OF B25-(ALPHA, BETA)-DEHYDRO-PHENYLALANINE INSULIN
分子名称:Insulin
著者Yang, Y., Weiss, M.
登録日2014-02-27
公開日2014-08-20
最終更新日2014-09-03
実験手法SOLUTION NMR
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MPI
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SOLUTION STRUCTURE OF B24G INSULIN
分子名称:insulin chain A, insulin chain B
著者Yang, Y., Wickramasinghe, N.P., Hua, Q., Weiss, M.A.
登録日2014-05-19
公開日2014-12-24
実験手法SOLUTION NMR
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIB
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CRYSTAL STRUCTURE OF HUMAN INSULIN MUTANT B20 D-ALA, B23 D-ALA
分子名称:Insulin A chain, Insulin B chain
著者Menting, J.G., Lawrence, M.C.
登録日2013-11-05
公開日2014-08-27
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OGA
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INSULIN IN COMPLEX WITH SITE 1 OF THE HUMAN INSULIN RECEPTOR
分子名称:Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ...
著者Lawrence, M.C., Menting, J.G.
登録日2014-01-15
公開日2014-08-27
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
1J73
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CRYSTAL STRUCTURE OF AN UNSTABLE INSULIN ANALOG WITH NATIVE ACTIVITY.
分子名称:insulin a, insulin b, ZINC ION
著者Wan, Z., Zhao, M., Nakagawa, S., Jia, W., Weiss, M.A.
登録日2001-05-15
公開日2001-05-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1JCA
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NON-STANDARD DESIGN OF UNSTABLE INSULIN ANALOGUES WITH ENHANCED ACTIVITY
分子名称:insulin a, insulin b, ZINC ION
著者Weiss, M.A., Wan, Z., Zhao, M., Chu, Y.-C., Nakagawa, S.H., Burke, G.T., Jia, W., Hellmich, R., Katsoyannis, P.G.
登録日2001-06-08
公開日2001-06-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002