Author results

3JCM
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CRYO-EM STRUCTURE OF THE SPLICEOSOMAL U4/U6.U5 TRI-SNRNP
Descriptor:Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-processing factor 31, ...
Authors:Wan, R., Yan, C., Bai, R., Wang, L., Huang, M., Wong, C.C., Shi, Y.
Deposit date:2015-12-23
Release date:2016-02-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Science, 351, 2016
5GMK
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CRYO-EM STRUCTURE OF THE CATALYTIC STEP I SPLICEOSOME (C COMPLEX) AT 3.4 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, U5 snRNA, ...
Authors:Wan, R., Yan, C., Bai, R., Huang, G., Shi, Y.
Deposit date:2016-07-14
Release date:2016-08-17
Last modified:2016-12-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of a yeast catalytic step I spliceosome at 3.4 angstrom resolution
Science, 353, 2016
5Y88
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CRYO-EM STRUCTURE OF THE INTRON-LARIAT SPLICEOSOME READY FOR DISASSEMBLY FROM S.CEREVISIAE AT 3.5 ANGSTROM
Descriptor:Pre-mRNA-splicing factor 8, U5 snRNA, Pre-mRNA-splicing factor SNU114, ...
Authors:Wan, R., Yan, C., Bai, R., Lei, J., Shi, Y.
Deposit date:2017-08-20
Release date:2018-08-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae
Cell(Cambridge,Mass.), 171, 2017
5YLZ
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CRYO-EM STRUCTURE OF THE POST-CATALYTIC SPLICEOSOME FROM SACCHAROMYCES CEREVISIAE AT 3.6 ANGSTROM
Descriptor:Pre-mRNA-splicing factor 8, U5 snRNA, Pre-mRNA-splicing factor SNU114, ...
Authors:Wan, R., Yan, C., Bai, R., Lei, J., Shi, Y.
Deposit date:2017-10-20
Release date:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae
Cell, 171, 2017
5GM6
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CRYO-EM STRUCTURE OF THE ACTIVATED SPLICEOSOME (BACT COMPLEX) AT 3.5 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Pre-mRNA-splicing factor SNU114, ...
Authors:Yan, C., Wan, R., Bai, R., Huang, G., Shi, Y.
Deposit date:2016-07-12
Release date:2016-09-21
Last modified:2016-12-28
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of a yeast activated spliceosome at 3.5 angstrom resolution
Science, 353, 2016
5WSG
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CRYO-EM STRUCTURE OF THE CATALYTIC STEP II SPLICEOSOME (C* COMPLEX) AT 4.0 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Pre-mRNA-splicing factor CWC21, ...
Authors:Yan, C., Wan, R., Bai, R., Huang, G., Shi, Y.
Deposit date:2016-12-07
Release date:2017-01-25
Last modified:2017-08-09
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of a yeast step II catalytically activated spliceosome
Science, 355, 2017
5ZWM
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CRYO-EM STRUCTURE OF THE YEAST PRE-B COMPLEX AT AN AVERAGE RESOLUTION OF 3.4~4.6 ANGSTROM (TRI-SNRNP AND U2 SNRNP PART)
Descriptor:Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-processing factor 31, ...
Authors:Bai, R., Wan, R., Yan, C., Lei, J., Shi, Y.
Deposit date:2018-05-16
Release date:2018-08-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Science, 360, 2018
5ZWN
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CRYO-EM STRUCTURE OF THE YEAST PRE-B COMPLEX AT AN AVERAGE RESOLUTION OF 3.3 ANGSTROM (PART II: U1 SNRNP REGION)
Descriptor:pre-mRNA, U1 snRNA, U1 small nuclear ribonucleoprotein 70 kDa homolog, ...
Authors:Bai, R., Wan, R., Yan, C., Lei, J., Shi, Y.
Deposit date:2018-05-16
Release date:2018-08-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Science, 360, 2018
5ZWO
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CRYO-EM STRUCTURE OF THE YEAST B COMPLEX AT AVERAGE RESOLUTION OF 3.9 ANGSTROM
Descriptor:Pre-mRNA-splicing factor 8, U4/U6 small nuclear ribonucleoprotein PRP4, Pre-mRNA-processing factor 31, ...
Authors:Bai, R., Wan, R., Yan, C., Shi, Y.
Deposit date:2018-05-16
Release date:2018-08-29
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Science, 360, 2018
3JB9
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CRYO-EM STRUCTURE OF THE YEAST SPLICEOSOME AT 3.6 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor spp42, Pre-mRNA-splicing factor cwf10, U5 snRNA, ...
Authors:Yan, C., Hang, J., Wan, R., Huang, M., Wong, C., Shi, Y.
Deposit date:2015-08-09
Release date:2015-09-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a yeast spliceosome at 3.6-angstrom resolution
Science, 349, 2015
4M75
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CRYSTAL STRUCTURE OF LSM1-7 COMPLEX
Descriptor:U6 snRNA-associated Sm-like protein Lsm1, U6 snRNA-associated Sm-like protein Lsm2, U6 snRNA-associated Sm-like protein Lsm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-10-23
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M77
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP I212121
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.111 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M78
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX, SPACE GROUP P21
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7A
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE 3' END SEQUENCE OF U6 SNRNA
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
4M7D
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CRYSTAL STRUCTURE OF LSM2-8 COMPLEX BOUND TO THE RNA FRAGMENT CGUUU
Descriptor:U6 snRNA-associated Sm-like protein LSm8, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ...
Authors:Zhou, L., Hang, J., Zhou, Y., Wan, R., Lu, G., Yan, C., Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
5M23
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MODULATION OF MLL1 METHYLTRANSFERASE ACTIVITY
Descriptor:WD repeat-containing protein 5, 4-[(~{E})-[4-[[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-pentanoyl]amino]propanoyl]amino]methyl]phenyl]diazenyl]-~{N}-[(2~{S})-3-methyl-1-oxidanylidene-butan-2-yl]benzamide
Authors:Srinivasan, V.
Deposit date:2016-10-11
Release date:2017-06-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia.
Chem Sci, 8, 2017
5M25
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MODULATION OF MLL1 METHYLTRANSFERASE ACTIVITY
Descriptor:WD repeat-containing protein 5, (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-~{N}-[(2~{S})-1-[[4-[(~{E})-[4-(hydroxymethyl)phenyl]diazenyl]phenyl]methylamino]-1-oxidanylidene-propan-2-yl]pentanamide
Authors:Srinivasan, V.
Deposit date:2016-10-11
Release date:2017-06-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia.
Chem Sci, 8, 2017
5MPS
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STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Yeast UBC4 gene for ubiquitin-conjugating enzyme, UBC4 gene exon, U2 snRNA, ...
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-18
Release date:2017-01-18
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
5MQ0
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STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Yeast UBC4 gene for ubiquitin-conjugating enzyme, 5'-EXON OF UBC4 PRE-MRNA, S.cerevisiae chromosome II reading frame ORF YBR230c, ...
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017