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7BU5
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BU of 7bu5 by Molmil
Crystal Structure of Human SLX4 and MUS81
Descriptor: GLYCINE, MUS81 endonuclease homolog (Yeast), isoform CRA_b, ...
Authors:Wan, B, Wu, J, Lei, M.
Deposit date:2020-04-04
Release date:2021-04-07
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SLX4 control MUS81 endonuclease function in telomere through an intermolecular SAP domain
To be published
4ZOU
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BU of 4zou by Molmil
Crystal structure of the BTB domain of SLX4
Descriptor: Structure-specific endonuclease subunit SLX4
Authors:Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M.
Deposit date:2015-05-07
Release date:2016-05-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The BTB domain is both a structural and functional pivot of the SLX4-nuclease complex
to be published
4M7C
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BU of 4m7c by Molmil
Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2
Descriptor: Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2
Authors:Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M.
Deposit date:2013-08-12
Release date:2013-09-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Cell Rep, 4, 2013
6J0W
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BU of 6j0w by Molmil
Crystal Structure of Yeast Rtt107 and Nse6
Descriptor: Peptide from DNA repair protein KRE29, Regulator of Ty1 transposition protein 107
Authors:Wan, B, Wu, J, Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0V
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BU of 6j0v by Molmil
Crystal Structure of Yeast Rtt107
Descriptor: Regulator of Ty1 transposition protein 107
Authors:Wan, B, Wu, J, Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.314 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0Y
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BU of 6j0y by Molmil
Crystal Structure of Yeast Rtt107 and Slx4
Descriptor: Peptide from Structure-specific endonuclease subunit SLX4, Regulator of Ty1 transposition protein 107
Authors:Wan, B, Wu, J, Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0X
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BU of 6j0x by Molmil
Crystal Structure of Yeast Rtt107 and Mms22
Descriptor: Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22, Regulator of Ty1 transposition protein 107
Authors:Wan, B, Wu, J, Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
5DOI
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BU of 5doi by Molmil
Crystal structure of Tetrahymena p45N and p19
Descriptor: Telomerase associated protein p45, Telomerase-associated protein 19
Authors:Wan, B, Tang, T, Wu, J, Lei, M.
Deposit date:2015-09-11
Release date:2015-11-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
5DOF
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BU of 5dof by Molmil
Crystal structure of Tetrahymena p19
Descriptor: Telomerase-associated protein 19
Authors:Wan, B, Tang, T, Wu, J, Lei, M.
Deposit date:2015-09-11
Release date:2015-11-25
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.
Nat.Struct.Mol.Biol., 22, 2015
5DOK
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BU of 5dok by Molmil
Crystal structure of Tetrahymena p45C
Descriptor: MAGNESIUM ION, Telomerase associated protein p45
Authors:Wan, B, Tang, T, Wu, J, Lei, M.
Deposit date:2015-09-11
Release date:2015-11-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
3U85
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BU of 3u85 by Molmil
Crystal structure of human menin in complex with MLL1
Descriptor: Histone-lysine N-methyltransferase 2A, Menin
Authors:Huang, J, Wan, B, Lei, M.
Deposit date:2011-10-15
Release date:2012-02-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3U86
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BU of 3u86 by Molmil
Crystal structure of human menin in complex with JunD
Descriptor: Menin, Transcription factor jun-D
Authors:Huang, J, Wan, B, Lei, M.
Deposit date:2011-10-15
Release date:2012-02-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.843 Å)
Cite:The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3U88
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BU of 3u88 by Molmil
Crystal structure of human menin in complex with MLL1 and LEDGF
Descriptor: (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ...
Authors:Huang, J, Wan, B, Lei, M.
Deposit date:2011-10-16
Release date:2012-02-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3U84
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BU of 3u84 by Molmil
Crystal Structure of Human Menin
Descriptor: Menin
Authors:Huang, J, Wan, B, Lei, M.
Deposit date:2011-10-15
Release date:2012-02-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3TOJ
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BU of 3toj by Molmil
Structure of the SPRY domain of human Ash2L
Descriptor: Set1/Ash2 histone methyltransferase complex subunit ASH2
Authors:Chen, Y, Cao, F, Wan, B, Dou, Y, Lei, M.
Deposit date:2011-09-05
Release date:2012-01-25
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
Cell Res., 22, 2012
3RSN
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BU of 3rsn by Molmil
Crystal Structure of the N-terminal region of Human Ash2L
Descriptor: Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION
Authors:Chen, Y, Wan, B, Wang, K.C, Cao, F, Yang, Y, Protacio, A, Dou, Y, Chang, H.Y, Lei, M.
Deposit date:2011-05-02
Release date:2011-06-22
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.
Embo Rep., 12, 2011
7RRB
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BU of 7rrb by Molmil
IDO1 IN COMPLEX WITH COMPOUND 9
Descriptor: 3-[4-(6-cyclopropylpyridin-3-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, Indoleamine 2,3-dioxygenase 1
Authors:Lesburg, C.A.
Deposit date:2021-08-09
Release date:2022-03-16
Last modified:2022-05-11
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
J.Med.Chem., 65, 2022
7RRC
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BU of 7rrc by Molmil
IDO1 IN COMPLEX WITH COMPOUND 14
Descriptor: Indoleamine 2,3-dioxygenase 1, N-(4-fluorophenyl)-3-{4-[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}oxetane-3-carboxamide
Authors:Lesburg, C.A.
Deposit date:2021-08-09
Release date:2022-03-16
Last modified:2022-05-11
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
J.Med.Chem., 65, 2022
7RRD
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BU of 7rrd by Molmil
IDO1 IN COMPLEX WITH COMPOUND S-1
Descriptor: 3-[4-(1H-benzimidazol-2-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, Indoleamine 2,3-dioxygenase 1
Authors:Lesburg, C.A.
Deposit date:2021-08-09
Release date:2022-08-24
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Oxetane promise delivered: discovery of long acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing
To Be Published
7LTO
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BU of 7lto by Molmil
Nse5-6 complex
Descriptor: Non-structural maintenance of chromosome element 5, Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera
Authors:Yu, Y, Li, S.B, Zheng, S, Tangy, S, Koyi, C, Wan, B.B, Kung, H.H, Andrej, S, Alex, K, Patel, D.J, Zhao, X.L.
Deposit date:2021-02-19
Release date:2021-05-19
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
5AGR
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BU of 5agr by Molmil
Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP
Descriptor: 1,2-ETHANEDIOL, 3-AMINOMETHYL-7-(ETHOXY)-3H-BENZO[C][1,2]OXABOROL-1-OL modified adenosine, LEUCINE, ...
Authors:Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGT
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BU of 5agt by Molmil
Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-4-chloro-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP
Descriptor: 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, GLYCEROL, LEUCINE--TRNA LIGASE, ...
Authors:Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGS
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BU of 5ags by Molmil
Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct 3-(Aminomethyl)-4-bromo-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP
Descriptor: 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE, LEUCYL-TRNA SYNTHETASE, METHIONINE
Authors:Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
4DNC
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BU of 4dnc by Molmil
Crystal structure of human MOF in complex with MSL1
Descriptor: Histone acetyltransferase KAT8, Male-specific lethal 1 homolog, ZINC ION
Authors:Huang, J, Lei, M.
Deposit date:2012-02-08
Release date:2012-07-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex.
Cell Res., 22, 2012
7X5C
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BU of 7x5c by Molmil
Solution structure of Tetrahymena p75OB1-p50PBM
Descriptor: Telomerase associated protein p50PBM, Telomerase-associated protein p75OB1
Authors:Wu, B, Tang, T, Xue, H.J, Wu, J, Lei, M.
Deposit date:2022-03-04
Release date:2022-10-19
Method:SOLUTION NMR
Cite:Association of the CST complex and p50 in Tetrahymena is crucial for telomere maintenance
Structure, 2022

 

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