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8FTG
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BU of 8ftg by Molmil
Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-Caffeine VHH Antibody, CAFFEINE, ...
Authors:Horn, J.R, Smith, C.A, Sonneson, G.J, Walter, R.
Deposit date:2023-01-12
Release date:2023-06-07
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Molecular recognition requires dimerization of a VHH antibody.
Mabs, 15, 2023
1YGE
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BU of 1yge by Molmil
LIPOXYGENASE-1 (SOYBEAN) AT 100K
Descriptor: FE (III) ION, LIPOXYGENASE-1
Authors:Minor, W, Steczko, J, Stec, B, Otwinowski, Z, Bolin, J.T, Walter, R, Axelrod, B.
Deposit date:1996-06-04
Release date:1997-07-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution.
Biochemistry, 35, 1996
4POU
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BU of 4pou by Molmil
VHH-metal in Complex with RNase A
Descriptor: Ribonuclease pancreatic, VHH Antibody
Authors:Fanning, S.W, Walter, R, Horn, J.R.
Deposit date:2014-02-26
Release date:2014-09-24
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
4POY
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BU of 4poy by Molmil
Engineered Dual Specific VHH antibody
Descriptor: VHH-metal
Authors:Fanning, S.W, Walter, R, Horn, J.R.
Deposit date:2014-02-26
Release date:2014-09-24
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
4PPT
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BU of 4ppt by Molmil
Engineered Dual Specific VHH Antibody in Complex with a Nickel (II) Ion
Descriptor: Engineered single domain VHH antibody, NICKEL (II) ION, SULFATE ION
Authors:Fanning, S.W, Walter, R, Horn, J.R.
Deposit date:2014-02-27
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
2HC1
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BU of 2hc1 by Molmil
Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta.
Descriptor: ACETATE ION, CHLORIDE ION, Receptor-type tyrosine-protein phosphatase beta
Authors:Evdokimov, A.G, Pokross, M, Walter, R, Mekel, M.
Deposit date:2006-06-14
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2HC2
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BU of 2hc2 by Molmil
Engineered protein tyrosine phosphatase beta catalytic domain
Descriptor: MAGNESIUM ION, Receptor-type tyrosine-protein phosphatase beta, SODIUM ION
Authors:Evdokimov, A.G, Pokross, M, Walter, R, Mekel, M.
Deposit date:2006-06-15
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
1OS1
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BU of 1os1 by Molmil
Structure of Phosphoenolpyruvate Carboxykinase complexed with ATP,Mg, Ca and pyruvate.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ...
Authors:Sudom, A, Walters, R, Pastushok, L, Goldie, D, Prasad, L, Delbaere, L.T, Goldie, H.
Deposit date:2003-03-18
Release date:2003-09-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanisms of activation of phosphoenolpyruvate carboxykinase from Escherichia coli by Ca2+ and of desensitization by trypsin.
J.BACTERIOL., 185, 2003
4XI3
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BU of 4xi3 by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene
Descriptor: Bazedoxifene, Estrogen receptor
Authors:Fanning, S.W, Mayne, C.G, Toy, W, Carlson, K, Greene, B, Nowak, J, Walter, R, Panchamukhi, S, Tajhorshid, E, Nettles, K.W, Chandarlapaty, S, Katzenellenbogen, J, Greene, G.L.
Deposit date:2015-01-06
Release date:2016-01-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.491 Å)
Cite:The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Elife, 7, 2018
2I4H
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BU of 2i4h by Molmil
Structural studies of protein tyrosine phosphatase beta catalytic domain co-crystallized with a sulfamic acid inhibitor
Descriptor: CHLORIDE ION, MAGNESIUM ION, N-(TERT-BUTOXYCARBONYL)-L-TYROSYL-N-METHYL-4-(SULFOAMINO)-L-PHENYLALANINAMIDE, ...
Authors:Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
Deposit date:2006-08-21
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I3R
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BU of 2i3r by Molmil
Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta
Descriptor: CHLORIDE ION, Receptor-type tyrosine-protein phosphatase beta
Authors:Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
Deposit date:2006-08-20
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I3U
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BU of 2i3u by Molmil
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Descriptor: Receptor-type tyrosine-protein phosphatase beta
Authors:Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
Deposit date:2006-08-20
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I4E
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BU of 2i4e by Molmil
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Descriptor: Receptor-type tyrosine-protein phosphatase beta, VANADATE ION
Authors:Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
Deposit date:2006-08-21
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I4G
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BU of 2i4g by Molmil
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with a sulfamic acid (soaking experiment)
Descriptor: CHLORIDE ION, N-(TERT-BUTOXYCARBONYL)-L-TYROSYL-N-METHYL-4-(SULFOAMINO)-L-PHENYLALANINAMIDE, Receptor-type tyrosine-protein phosphatase beta
Authors:Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
Deposit date:2006-08-21
Release date:2006-08-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2I5X
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BU of 2i5x by Molmil
Engineering the PTPbeta catalytic domain with improved crystallization properties
Descriptor: (4-ETHYLPHENYL)SULFAMIC ACID, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Klopfenstein, S.
Deposit date:2006-08-26
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2HFP
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BU of 2hfp by Molmil
Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands
Descriptor: 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE, Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment
Authors:Pokross, M.E, Evdokimov, A.G, Walter, R.L, Mekel, M.J, Hopkins, C.R.
Deposit date:2006-06-25
Release date:2006-09-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
Bioorg.Med.Chem.Lett., 16, 2006
3D9A
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BU of 3d9a by Molmil
High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme
Descriptor: Heavy Chain of HyHel10 Antibody Fragment (Fab), Light Chain of HyHel10 Antibody Fragment (Fab), Lysozyme C
Authors:DeSantis, M.E, Li, M, Shanmuganathan, A, Acchione, M, Walter, R, Wlodawer, A, Smith-Gill, S.
Deposit date:2008-05-27
Release date:2008-06-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies.
Mol.Immunol., 47, 2009
2RHS
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BU of 2rhs by Molmil
PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
Descriptor: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
Authors:Evdokimov, A.G, Mekel, M.
Deposit date:2007-10-09
Release date:2007-11-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
2RHQ
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BU of 2rhq by Molmil
PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
Descriptor: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
Authors:Evdokimov, A.G, Mekel, M.
Deposit date:2007-10-09
Release date:2007-11-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
3PZW
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BU of 3pzw by Molmil
Soybean lipoxygenase-1 - re-refinement
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, FE (II) ION, ...
Authors:Chruszcz, M, Minor, W.
Deposit date:2010-12-14
Release date:2011-01-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Determination of protein structures - a series of fortunate events.
Biophys.J., 95, 2008
1FGT
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BU of 1fgt by Molmil
LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q697N MUTANT
Descriptor: FE (III) ION, SEED LIPOXYGENASE-1
Authors:Tomchick, D.R, Minor, W, Holman, T.
Deposit date:2000-07-28
Release date:2001-07-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1F8N
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BU of 1f8n by Molmil
LIPOXYGENASE-1 (SOYBEAN) AT 100K, NEW REFINEMENT
Descriptor: FE (II) ION, LIPOXYGENASE-1
Authors:Tomchick, D.R, Minor, W, Holman, T.
Deposit date:2000-06-30
Release date:2001-07-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGM
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BU of 1fgm by Molmil
LIPOXYGENASE-1 (SOYBEAN) AT 100K, N694H MUTANT
Descriptor: FE (III) ION, SEED LIPOXYGENASE-1
Authors:Tomchick, D.R, Minor, W, Holman, T.R.
Deposit date:2000-07-28
Release date:2001-10-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGQ
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BU of 1fgq by Molmil
LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q495E MUTANT
Descriptor: FE (III) ION, SEED LIPOXYGENASE-1
Authors:Tomchick, D.R, Minor, W, Holman, T.
Deposit date:2000-07-28
Release date:2001-07-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGR
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BU of 1fgr by Molmil
LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q697E MUTANT
Descriptor: FE (III) ION, SEED LIPOXYGENASE-1
Authors:Tomchick, D.R, Minor, W, Holman, T.
Deposit date:2000-07-28
Release date:2001-07-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001

 

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