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7BL7
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BU of 7bl7 by Molmil
Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (P21212 form)
Descriptor: URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase
Authors:Walter, P, Labesse, G, Haouz, A, Mechaly, A.E, Munier-Lehmann, H.
Deposit date:2021-01-18
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Febs J., 289, 2022
7BES
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BU of 7bes by Molmil
CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP
Descriptor: URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase
Authors:Bous, J, Trapani, S, Walter, P, Bron, P, Munier-Lehmann, H.
Deposit date:2020-12-24
Release date:2022-01-12
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Febs J., 289, 2022
7BIX
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BU of 7bix by Molmil
Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (C2 form)
Descriptor: URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase
Authors:Labesse, G, Walter, P, Haouz, A, Mechaly, A.E, Munier-Lehmann, H.
Deposit date:2021-01-13
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Febs J., 289, 2022
6CAJ
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BU of 6caj by Molmil
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ...
Authors:Tsai, J.C, Miller-Vedam, L.E, Anand, A.A, Jaishankar, P, Nguyen, H.C, Renslo, A.R, Frost, A, Walter, P.
Deposit date:2018-01-31
Release date:2018-04-11
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Science, 359, 2018
8JHU
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BU of 8jhu by Molmil
Legionella effector protein SidI
Descriptor: Legionella pneumophila effector protein SidI
Authors:Wang, L, Subramanian, A, Mukherjee, S, Walter, P.
Deposit date:2023-05-25
Release date:2023-08-30
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response
Nat.Cell Biol., 25, 2023
7UPT
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BU of 7upt by Molmil
Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (open conformation)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P.
Deposit date:2022-04-16
Release date:2022-06-15
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.
Elife, 11, 2022
7UPR
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BU of 7upr by Molmil
Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (closed conformation)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Outer mitochondrial transmembrane helix translocase, ...
Authors:Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P.
Deposit date:2022-04-16
Release date:2022-06-15
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.
Elife, 11, 2022
3SDM
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BU of 3sdm by Molmil
Structure of oligomeric kinase/RNase Ire1 in complex with an oligonucleotide
Descriptor: Serine/threonine-protein kinase/endoribonuclease IRE1
Authors:Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P.
Deposit date:2011-06-09
Release date:2011-07-13
Method:X-RAY DIFFRACTION (6.6 Å)
Cite:Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
Bmc Biol., 9, 2011
7KKJ
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BU of 7kkj by Molmil
Structure of anti-SARS-CoV-2 Spike nanobody mNb6
Descriptor: CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
7KKK
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BU of 7kkk by Molmil
SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
7KKL
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BU of 7kkl by Molmil
SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
3NG1
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BU of 3ng1 by Molmil
N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS
Descriptor: 1,2-ETHANEDIOL, CADMIUM ION, SIGNAL SEQUENCE RECOGNITION PROTEIN FFH, ...
Authors:Freymann, D.M, Stroud, R.M, Walter, P.
Deposit date:1998-09-13
Release date:1999-07-30
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nat.Struct.Biol., 6, 1999
1K9W
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BU of 1k9w by Molmil
HIV-1(MAL) RNA Dimerization Initiation Site
Descriptor: HIV-1 DIS(Mal)UU RNA, MAGNESIUM ION
Authors:Ennifar, E, Walter, P, Ehresmann, B, Ehresmann, C, Dumas, P.
Deposit date:2001-10-31
Release date:2001-11-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structures of coaxially stacked kissing complexes of the HIV-1 RNA dimerization initiation site.
Nat.Struct.Biol., 8, 2001
3SDJ
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BU of 3sdj by Molmil
Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1
Descriptor: N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, Serine/threonine-protein kinase/endoribonuclease IRE1
Authors:Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P.
Deposit date:2011-06-09
Release date:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structural and functional basis for RNA cleavage by Ire1.
Bmc Biol., 9, 2011
1CQ5
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BU of 1cq5 by Molmil
NMR STRUCTURE OF SRP RNA DOMAIN IV
Descriptor: SRP RNA DOMAIN IV
Authors:Schmitz, U, James, T.L, Behrens, S, Freymann, D.M, Lukavsky, P, Walter, P.
Deposit date:1999-08-05
Release date:1999-08-23
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of the phylogenetically most conserved domain of SRP RNA.
RNA, 5, 1999
7TRJ
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BU of 7trj by Molmil
The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit
Descriptor: Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ...
Authors:Wang, L, Schoof, M, Lawrence, R, Boone, M, Frost, A, Walter, P.
Deposit date:2022-01-29
Release date:2022-04-27
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.
Elife, 11, 2022
7L7G
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BU of 7l7g by Molmil
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ)
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ...
Authors:Tsai, J.C, Miller-Vedam, L.E, Anand, A, Jaishankar, P, Nguyen, H.C, Wang, L, Renslo, A.R, Frost, A, Walter, P.
Deposit date:2020-12-28
Release date:2021-03-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:eIF2B conformation and assembly state regulates the integrated stress response.
Elife, 10, 2021
3DLU
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BU of 3dlu by Molmil
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.
Descriptor: BROMIDE ION, MALONATE ION, Signal recognition particle 19 kDa protein
Authors:Egea, P.F, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-29
Release date:2008-11-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
Plos One, 3, 2008
3DM9
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BU of 3dm9 by Molmil
Structures and Conformations in Solution of the Signal Recognition Particle Receptor from the archaeon Pyrococcus furiosus
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Signal recognition particle receptor
Authors:Egea, P.F, Tsuruta, H, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-30
Release date:2008-11-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane.
Plos One, 3, 2008
3DLV
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BU of 3dlv by Molmil
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.
Descriptor: Signal recognition particle 19 kDa protein
Authors:Egea, P.F, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
Plos One, 3, 2008
3DM5
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BU of 3dm5 by Molmil
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.
Descriptor: ACETATE ION, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Egea, P.F, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-30
Release date:2008-11-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
Plos One, 3, 2008
3DMD
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BU of 3dmd by Molmil
Structures and Conformations in Solution of the Signal Recognition Particle Receptor from the archaeon Pyrococcus furiosus
Descriptor: GLYCEROL, SULFATE ION, Signal recognition particle receptor
Authors:Egea, P.F, Tsuruta, H, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-30
Release date:2008-11-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane.
Plos One, 3, 2008
3E70
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BU of 3e70 by Molmil
Structures and conformations in solution of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus Furiosus
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Signal recognition particle receptor
Authors:Egea, P.F, Tsuruta, H, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-08-17
Release date:2008-11-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane.
Plos One, 3, 2008
1Y90
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BU of 1y90 by Molmil
HIV-1 Dis(Mal) Duplex Mn-Soaked
Descriptor: 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3', MANGANESE (II) ION
Authors:Ennifar, E, Walter, P, Dumas, P.
Deposit date:2004-12-14
Release date:2004-12-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:A crystallographic study of the binding of 13 metal ions to two related RNA duplexes
Nucleic Acids Res., 31, 2003
3FBV
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BU of 3fbv by Molmil
Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1
Descriptor: N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, Serine/threonine-protein kinase/endoribonuclease IRE1
Authors:Korennykh, A.V, Egea, P.F, Korostelev, A.A, Finer-Moore, J, Zhang, C, Shokat, K.M, Stroud, R.M, Walter, P.
Deposit date:2008-11-19
Release date:2008-12-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The unfolded protein response signals through high-order assembly of Ire1.
Nature, 457, 2009

 

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