Author results

5FWE
  • Download 5fwe
  • View 5fwe
Molmil generated image of 5fwe
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H4(1-15)R3ME2S PEPTIDE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, SYNTHETIC PEPTIDE, NICKEL (II) ION, ...
Authors:Chowdhury, R., Walport, L.J., Schofield, C.J.
Deposit date:2016-02-15
Release date:2016-04-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Arginine Demethylation is Catalysed by a Subset of Jmjc Histone Lysine Demethylases.
Nat.Commun., 7, 2016
6H8P
  • Download 6h8p
  • View 6h8p
Molmil generated image of 6h8p
JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND HISTONE H1.4(18-32)K26ME3 PEPTIDE (15-MER)
Descriptor:Lysine-specific demethylase 4A, Histone H1.4, NICKEL (II) ION, ...
Authors:Chowdhury, R., Walport, L.J., Schofield, C.J.
Deposit date:2018-08-03
Release date:2018-08-15
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.
FEBS Lett., 592, 2018
3ZLI
  • Download 3zli
  • View 3zli
Molmil generated image of 3zli
CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY
Descriptor:HISTONE DEMETHYLASE UTY, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ...
Authors:Vollmar, M., Gileadi, C., Shrestha, L., Goubin, S., Johansson, C., Krojer, T., Raynor, J.W., Bradley, A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
Deposit date:2013-01-31
Release date:2013-02-27
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Uty(Kdm6C) is a Male-Specific Nepsilon-Methyl Lysyl Demethylase.
J.Biol.Chem., 289, 2014
3ZPO
  • Download 3zpo
  • View 3zpo
Molmil generated image of 3zpo
CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY WITH BOUND GSK J1
Descriptor:HISTONE DEMETHYLASE UTY, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ZINC ION, ...
Authors:Vollmar, M., Gileadi, C., Shrestha, L., Goubin, S., Johansson, C., Krojer, T., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human Uty(Kdm6C) is a Male-Specific Nepislon-Methyl Lysyl Demethylase.
J.Biol.Chem., 289, 2014
3T3Y
  • Download 3t3y
  • View 3t3y
Molmil generated image of 3t3y
CRYSTAL STRUCTURE OF ALKB IN COMPLEX WITH FE(III) AND 2-(3-HYDROXYPICOLINOMIDO)ACETIC ACID
Descriptor:Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, N-[(3-hydroxypyridin-2-yl)carbonyl]glycine
Authors:Aik, W.S., McDonough, M.A., Schofield, C.J.
Deposit date:2011-07-25
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase.
J.Med.Chem., 55, 2012
3T4H
  • Download 3t4h
  • View 3t4h
Molmil generated image of 3t4h
CRYSTAL STRUCTURE OF ALKB IN COMPLEX WITH FE(III) AND N-OXALYL-S-(3-NITROBENZYL)-L-CYSTEINE
Descriptor:Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Ma, J., Aik, W.S., McDonough, M.A., Schofield, C.J.
Deposit date:2011-07-26
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase.
J.Med.Chem., 55, 2012
3T4V
  • Download 3t4v
  • View 3t4v
Molmil generated image of 3t4v
CRYSTAL STRUCTURE OF ALKB IN COMPLEX WITH FE(III) AND N-OXALYL-S-(2-NAPTHALENEMETHYL)-L-CYSTEINE
Descriptor:Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, N-(carboxycarbonyl)-S-(naphthalen-2-ylmethyl)-L-cysteine, ...
Authors:Aik, W.S., McDonough, M.A., Schofield, C.J.
Deposit date:2011-07-26
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.732 Å)
Cite:Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase.
J.Med.Chem., 55, 2012
3U4S
  • Download 3u4s
  • View 3u4s
Molmil generated image of 3u4s
HISTONE LYSINE DEMETHYLASE JMJD2A IN COMPLEX WITH T11C PEPTIDE SUBSTRATE CROSSLINKED TO N-OXALYL-D-CYSTEINE
Descriptor:Lysine-specific demethylase 4A, HISTONE 3 TAIL ANALOG (T11C Peptide), NICKEL (II) ION, ...
Authors:Ma, J., McDonough, M.A., Schofield, C.J.
Deposit date:2011-10-10
Release date:2012-02-08
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
Angew.Chem.Int.Ed.Engl., 51, 2012
4AI8
  • Download 4ai8
  • View 4ai8
Molmil generated image of 4ai8
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, SULFATE ION, GLYCEROL, ...
Authors:King, O.N.F., Chowdhury, R., Rose, N.R., McDonough, M.A., Clifton, I.J., Schofield, C.J., Kawamura, A.
Deposit date:2012-02-08
Release date:2012-10-03
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012
4AI9
  • Download 4ai9
  • View 4ai9
Molmil generated image of 4ai9
JMJD2A COMPLEXED WITH DAMINOZIDE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2012-02-08
Release date:2012-10-03
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012
4BIO
  • Download 4bio
  • View 4bio
Molmil generated image of 4bio
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH 8-HYDROXYQUINOLINE-5- CARBOXYLIC ACID
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (III) ION, 8-hydroxyquinoline-5-carboxylic acid, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-04-12
Release date:2013-04-24
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Chem Sci, 4, 2013
4BIS
  • Download 4bis
  • View 4bis
Molmil generated image of 4bis
JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Chowdhury, R., Thinnes, C., Schofield, C.J.
Deposit date:2013-04-12
Release date:2014-02-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Chem Sci, 4, 2013
4DO0
  • Download 4do0
  • View 4do0
Molmil generated image of 4do0
CRYSTAL STRUCTURE OF HUMAN PHF8 IN COMPLEX WITH DAMINOZIDE
Descriptor:Histone lysine demethylase PHF8, DAMINOZIDE, ZINC ION, ...
Authors:Krojer, T., Daniel, M., Ng, S.S., Walport, L.J., Chowdhury, R., Arrowsmith, C.H., Edwards, A., Bountra, C., Kawamura, A., Muller-Knapp, S., McDonough, M.A., von Delft, F., Schofield, C.J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2012-02-09
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:

4JHT
  • Download 4jht
  • View 4jht
Molmil generated image of 4jht
CRYSTAL STRUCTURE OF ALKB IN COMPLEX WITH 5-CARBOXY-8-HYDROXYQUINOLINE (IOX1)
Descriptor:Alpha-ketoglutarate-dependent dioxygenase AlkB, 8-hydroxyquinoline-5-carboxylic acid, MANGANESE (II) ION, ...
Authors:Aik, W.S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-03-05
Release date:2013-06-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
CHEM SCI, 4, 2013
4V2V
  • Download 4v2v
  • View 4v2v
Molmil generated image of 4v2v
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27ME3 PEPTIDE (25-29) ARK(ME3)SA
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Madden, S.K., Schofield, C.J.
Deposit date:2014-10-15
Release date:2014-11-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.
Epigenetics, 9, 2014
4V2W
  • Download 4v2w
  • View 4v2w
Molmil generated image of 4v2w
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27ME3 PEPTIDE (16-35)
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, NICKEL (II) ION, ...
Authors:Chowdhury, R., Zafred, D., Schofield, C.J.
Deposit date:2014-10-15
Release date:2014-11-26
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.
Epigenetics, 9, 2014
5LY1
  • Download 5ly1
  • View 5ly1
Molmil generated image of 5ly1
JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND MACROCYCLIC PEPTIDE INHIBITOR CP2 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ...
Authors:King, O.N.F., Chowdhury, R., Kawamura, A., Schofield, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5LY2
  • Download 5ly2
  • View 5ly2
Molmil generated image of 5ly2
JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND MACROCYCLIC PEPTIDE INHIBITOR CP2_R6KME3 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ...
Authors:CHOWDHURY, R., Madden, S.K., Hopkinson, R., SCHOFIELD, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017