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1GPW
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BU of 1gpw by Molmil
Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex.
Descriptor: AMIDOTRANSFERASE HISH, HISF PROTEIN, PHOSPHATE ION
Authors:Walker, M, Beismann-Driemeyer, S, Sterner, R, Wilmanns, M.
Deposit date:2001-11-12
Release date:2002-02-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Evidence for Ammonia Tunneling Across the (Beta Alpha)(8) Barrel of the Imidazole Glycerol Phosphate Synthase Bienzyme Complex.
Structure, 10, 2002
6PK9
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BU of 6pk9 by Molmil
Solution Structure of lncRNA (LINK-A) 20-nt Hexaloop Hairpin
Descriptor: RNA (5'-R(*GP*GP*AP*GP*GP*GP*UP*AP*GP*AP*CP*UP*CP*GP*CP*UP*CP*UP*CP*C)-3')
Authors:Amado, A.Y, Walker, M, Varani, G.
Deposit date:2019-06-28
Release date:2020-07-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the lncRNA LINK-A Hexaloop Hairpin in PI(3,4,5)P3 Interaction
To Be Published
1K9V
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BU of 1k9v by Molmil
Structural evidence for ammonia tunelling across the (beta-alpha)8-barrel of the imidazole glycerol phosphate synthase bienzyme complex
Descriptor: ACETIC ACID, Amidotransferase hisH
Authors:Douangamath, A, Walker, M, Beismann-Driemeyer, S, Vega-Fernandez, M.C, Sterner, R, Wilmanns, M.
Deposit date:2001-10-31
Release date:2002-02-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex.
Structure, 10, 2002
2W17
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BU of 2w17 by Molmil
CDK2 in complex with the imidazole pyrimidine amide, compound (S)-8b
Descriptor: ACETATE ION, CELL DIVISION PROTEIN KINASE 2, N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amine
Authors:Jones, C.D, Andrews, D.M, Barker, A.J, Blades, K, Daunt, P, East, S, Geh, C, Graham, M.A, Johnson, K.M, Loddick, S.A, McFarland, H.M, McGregor, A, Moss, L, Rudge, D.A, Simpson, P.B, Swain, M.L, Tam, K.Y, Tucker, J.A, Walker, M, Brassington, C, Haye, H, McCall, E.
Deposit date:2008-10-15
Release date:2008-11-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Discovery of Azd5597, a Potent Imidazole Pyrimidine Amide Cdk Inhibitor Suitable for Intravenous Dosing.
Bioorg.Med.Chem.Lett., 18, 2008
6MXQ
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BU of 6mxq by Molmil
Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation
Descriptor: RNA C-JUN TL
Authors:Walker, M, Shortridge, M, Varani, G.
Deposit date:2018-10-31
Release date:2020-05-06
Last modified:2020-11-18
Method:SOLUTION NMR
Cite:Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.
J.Mol.Biol., 432, 2020
6NOA
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BU of 6noa by Molmil
Solution Structure of the RNA element that recruits eIF3 to the 5'-UTR of c-Jun and regulates specialized translation initiation (apical loop)
Descriptor: C-JUN SL1
Authors:Walker, M, Shortridge, M, Varani, G.
Deposit date:2019-01-16
Release date:2020-07-22
Last modified:2020-11-18
Method:SOLUTION NMR
Cite:Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.
J.Mol.Biol., 432, 2020
7O4D
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BU of 7o4d by Molmil
QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline
Descriptor: 8-methyl-2-(4-methyl-3-piperazin-1-ylsulfonyl-phenyl)imidazo[1,2-a]pyridine, FLAVIN-ADENINE DINUCLEOTIDE, Ribosyldihydronicotinamide dehydrogenase [quinone], ...
Authors:Gould, N.L, Scherer, G.R, Carvalh, S, Shurrush, K, Edry, E, Elkobi, A, David, O, Dym, O, Albeck, S, Peleg, Y, Germain, N, Babaev, I, Sharir, H, Lefker, B, Subramanyam, C, Barr, H, Rosenblum, K.
Deposit date:2021-04-06
Release date:2022-08-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice.
J.Clin.Invest., 133, 2023
1W82
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BU of 1w82 by Molmil
p38 Kinase crystal structure in complex with small molecule inhibitor
Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[(3Z)-5-TERT-BUTYL-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-YLIDENE]-N'-(4-CHLOROPHENYL)UREA
Authors:Tickle, J, Jhoti, H, Cleasby, A, Devine, L.
Deposit date:2004-09-16
Release date:2005-02-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation
J.Med.Chem., 48, 2005
3ZXH
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BU of 3zxh by Molmil
MMP-13 complexed with 2-Napthylsulfonamide hydroxamic acid inhibitor
Descriptor: CALCIUM ION, COLLAGENASE 3, GLYCEROL, ...
Authors:Clark, K.L, Kulathila, R.
Deposit date:2011-08-10
Release date:2011-10-19
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Potent and Selective 2-Naphthylsulfonamide Substituted Hydroxamic Acid Inhibitors of Matrix Metalloproteinase-13.
Bioorg.Med.Chem.Lett., 21, 2011
2W06
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BU of 2w06 by Molmil
Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5c
Descriptor: 4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2
Authors:Anderson, M, Andrews, D.M, Barker, A.J, Brassington, C.A, Byth, K.F, Culshaw, J.D, Finlay, M.R.V, Fisher, E, Mcmiken, H.H.J, Green, C.P, Heaton, D.W, Nash, I.A, Newcombe, N.J, Oakes, S.E, Roberts, A, Stanway, J.J, Thomas, A.P, Tucker, J.A, Weir, H.M.
Deposit date:2008-08-08
Release date:2008-09-23
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Imidazoles: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
2W05
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BU of 2w05 by Molmil
Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5b
Descriptor: CELL DIVISION PROTEIN KINASE 2, N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE
Authors:Anderson, M, Andrews, D.M, Barker, A.J, Brassington, C.A, Breed, J, Byth, K.F, Culshaw, J.D, Finlay, M.R, Fisher, E, Green, C.P, Heaton, D.W, Nash, I.A, Newcombe, N.J, Oakes, S.E, Pauptit, R.A, Roberts, A, Stanway, J.J, Thomas, A.P, Tucker, J.A, Weir, H.M.
Deposit date:2008-08-08
Release date:2008-10-14
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Imidazoles: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3ZR4
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BU of 3zr4 by Molmil
STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA-ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX
Descriptor: GLUTAMINE, GLYCEROL, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF, ...
Authors:Vega, M.C, Kuper, J, Haeger, M.C, Mohrlueder, J, Marquardt, S, Sterner, R, Wilmanns, M.
Deposit date:2011-06-13
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Chem.Biol., 19, 2012

217705

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