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6OA9
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BU of 6oa9 by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6OAA
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BU of 6oaa by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6OAB
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BU of 6oab by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6QA2
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BU of 6qa2 by Molmil
R80A MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor: Nucleoside diphosphate kinase, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Dautant, A, Henri, J, Wales, T.E, Meyer, P, Engen, J.R, Georgescauld, F.
Deposit date:2018-12-18
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange.
Biochemistry, 58, 2019
7UY0
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BU of 7uy0 by Molmil
Crystal structure of human Fgr tyrosine kinase in complex with A-419259
Descriptor: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Du, S, Alvarado, J.J, Smithgall, T.E.
Deposit date:2022-05-06
Release date:2022-12-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr.
Structure, 30, 2022
7UY3
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BU of 7uy3 by Molmil
Crystal structure of human Fgr tyrosine kinase in complex with TL02-59
Descriptor: 1,2-ETHANEDIOL, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, ...
Authors:Du, S, Alvarado, J.J, Smithgall, T.E.
Deposit date:2022-05-06
Release date:2022-12-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr.
Structure, 30, 2022
8GMB
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BU of 8gmb by Molmil
Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible)
Descriptor: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK
Authors:Lin, D.Y, Andreotti, A.H.
Deposit date:2023-03-24
Release date:2023-08-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.
Elife, 12, 2024
8S9F
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BU of 8s9f by Molmil
Crystal structure of the kinase domain of Bruton's Tyrosine Kinase bound to dasatinib
Descriptor: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase BTK
Authors:Lin, D.Y, Andreotti, A.H.
Deposit date:2023-03-28
Release date:2023-08-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.
Elife, 12, 2024
8S93
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BU of 8s93 by Molmil
Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase
Descriptor: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ...
Authors:Lin, D.Y, Andreotti, A.H.
Deposit date:2023-03-27
Release date:2023-08-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.
Elife, 12, 2024
3V79
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BU of 3v79 by Molmil
Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence
Descriptor: DNA 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', DNA 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ...
Authors:Nam, Y, Sliz, P, Blacklow, S.
Deposit date:2011-12-20
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes.
Structure, 20, 2012
6BOF
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BU of 6bof by Molmil
Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Bera, A.K, Yan, W, Westover, K.D.
Deposit date:2017-11-20
Release date:2019-05-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov, 9, 2019
6CDD
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BU of 6cdd by Molmil
Npl4 zinc finger and MPN domains (Chaetomium thermophilum)
Descriptor: Npl4 zinc finger, ZINC ION
Authors:Bodnar, N.O, Rapoport, T.A.
Deposit date:2018-02-08
Release date:2018-07-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.58233714 Å)
Cite:Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.
Nat. Struct. Mol. Biol., 25, 2018
6CHS
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BU of 6chs by Molmil
Cdc48-Npl4 complex in the presence of ATP-gamma-S
Descriptor: MAGNESIUM ION, Npl4, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Kim, K.H, Bodnar, N.O, Walz, T, Rapoport, T.A.
Deposit date:2018-02-22
Release date:2018-07-04
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.
Nat. Struct. Mol. Biol., 25, 2018
6V4E
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BU of 6v4e by Molmil
Crystal Structure Analysis of Zebra Fish MDM
Descriptor: Protein Mdm4, Stapled peptide QSQQTF(0EH)NLWRLL(MK8)QN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
6V4G
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BU of 6v4g by Molmil
Crystal Structure Analysis of Zebra fish MDMX
Descriptor: Protein Mdm4, SULFATE ION, Stapled peptide QSQQTF(0EH)NLWRLE(MK8)QN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
6V4H
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BU of 6v4h by Molmil
Crystal Structure Analysis of Zebra Fish MDMX
Descriptor: Protein Mdm4, Stapled Peptide LSQETF(0EH)DLWKLL(MK8)EN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
6V4F
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BU of 6v4f by Molmil
Crystal Structure Analysis of Zebra Fish MDMX
Descriptor: Protein Mdm4, SULFATE ION, Stapled Peptide LSQETF(0EH)DLWKLE(MK8)EN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
6VO4
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BU of 6vo4 by Molmil
Crystal Structure Analysis of BFL1
Descriptor: Bcl-2-related protein A1
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2020-01-29
Release date:2020-06-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
Cell Chem Biol, 27, 2020
6MQN
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BU of 6mqn by Molmil
Crystal structure of KRAS V14I-GDP demonstrating disorder switch 1 conformation - Form 2
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Bera, A.K, Westover, K.D.
Deposit date:2018-10-10
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of the atypical activation mechanism of KRASV14I.
J.Biol.Chem., 294, 2019
6MQG
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BU of 6mqg by Molmil
Crystal structure of KRAS V14I-GDP demonstrating open switch 1 conformation - Form 1
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Bera, A.K, Westover, K.D.
Deposit date:2018-10-09
Release date:2019-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of the atypical activation mechanism of KRASV14I.
J.Biol.Chem., 294, 2019

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PDB entries from 2024-03-27

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