Author results

6R75
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CRYSTAL STRUCTURE OF HUMAN UBE2T E54R MUTANT
Descriptor:Ubiquitin-conjugating enzyme E2 T
Authors:Chaugule, V.K., Rennie, M.L., Walden, H., Arkinson, C., Kamarainen, O., Toth, R.
Deposit date:2019-03-28
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human Ube2T E54R mutant
To Be Published
6N13
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UBCH7-UB COMPLEX WITH R0RBR PARKIN AND PHOSPHOUBIQUITIN
Descriptor:E3 ubiquitin-protein ligase parkin, ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Condos, T.E.C., Dunkerley, K.M., Freeman, E.A., Barber, K.R., Aguirre, J.D., Chaugule, V.K., Xiao, Y., Konermann, L., Walden, H., Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2018-12-12
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018
5OJJ
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CRYSTAL STRUCTURE OF THE ZN-BOUND UBIQUITIN-CONJUGATING ENZYME UBE2T
Descriptor:Ubiquitin-conjugating enzyme E2 T, ACETATE ION, ZINC ION, ...
Authors:Morreale, F.E., Testa, A., Chaugule, V.K., Bortoluzzi, A., Ciulli, A., Walden, H.
Deposit date:2017-07-21
Release date:2017-10-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
J. Med. Chem., 60, 2017
5NGZ
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UBE2T IN COMPLEX WITH FRAGMENT EM04
Descriptor:Ubiquitin-conjugating enzyme E2 T, 1-(1,3-benzothiazol-2-yl)methanamine
Authors:Morreale, F.E., Bortoluzzi, A., Chaugule, V.K., Arkinson, C., Walden, H., Ciulli, A.
Deposit date:2017-03-21
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
J. Med. Chem., 60, 2017
5N2W
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WT-PARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5N38
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S65DPARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, DI(HYDROXYETHYL)ETHER, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5C1Z
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PARKIN (UBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, SULFATE ION, ...
Authors:kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C23
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PARKIN (S65DUBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, GLYCEROL, ...
Authors:Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
4CCG
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STRUCTURE OF AN E2-E3 COMPLEX
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 T, E3 UBIQUITIN-PROTEIN LIGASE FANCL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Hodson, C., Purkiss, A., Walden, H.
Deposit date:2013-10-22
Release date:2014-01-08
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Human Fancl Ring-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection.
Structure, 22, 2014
2LWR
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SOLUTION STRUCTURE OF RING2 DOMAIN FROM PARKIN
Descriptor:SD01679p, ZINC ION
Authors:Mercier, P., Spratt, D.E., Manczyk, N., Shaw, G.S.
Deposit date:2012-08-06
Release date:2013-06-12
Last modified:2014-10-15
Method:SOLUTION NMR
Cite:A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.
Nat Commun, 4, 2013
2M48
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SOLUTION STRUCTURE OF IBR-RING2 TANDEM DOMAIN FROM PARKIN
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE PARKIN, ZINC ION
Authors:Noh, Y.J., Mercier, P., Spratt, D.E., Shaw, G.S.
Deposit date:2013-01-30
Release date:2013-05-15
Last modified:2014-10-15
Method:SOLUTION NMR
Cite:A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.
Nat Commun, 4, 2013
3ZQS
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HUMAN FANCL CENTRAL DOMAIN
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE FANCL, PROLINE, HEXAETHYLENE GLYCOL, ...
Authors:Hodson, C., Cole, A.R., Purkiss-Trew, A., Walden, H.
Deposit date:2011-06-10
Release date:2011-07-20
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of Human Fancl, the E3 Ligase in the Fanconi Anemia Pathway.
J.Biol.Chem., 286, 2011
3K1L
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CRYSTAL STRUCTURE OF FANCL
Descriptor:Fancl, ZINC ION, MALTOSE, ...
Authors:Cole, A.R., Walden, H.
Deposit date:2009-09-28
Release date:2010-02-16
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structure of the catalytic subunit FANCL of the Fanconi anemia core complex
Nat.Struct.Mol.Biol., 17, 2010
3HVE
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: GIGAXONINBTB/3-BOX
Descriptor:Gigaxonin
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-16
Release date:2009-10-27
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQH
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-MACROH2ASBCPEP1
Descriptor:Speckle-type POZ protein, MacroH2A, ZINC ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-06
Release date:2009-10-20
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQI
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX/BTB/3-BOX-PUCSBC1
Descriptor:Speckle-type POZ protein, PucSBC1
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQL
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES:SPOPMATHX-PUCSBC1_PEP2
Descriptor:Speckle-type POZ protein, Puckered, SULFATE ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQM
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-CISBC2
Descriptor:Speckle-type POZ protein, Protein cubitus interruptus, SULFATE ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HSV
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-MACROH2ASBCPEP2
Descriptor:Speckle-type POZ protein, Core histone macro-H2A.1, ZINC ION, ...
Authors:Zhuang, M., Schulman, B.A., Miller, D.
Deposit date:2009-06-10
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HTM
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPBTB/3-BOX
Descriptor:Speckle-type POZ protein
Authors:Zhuang, M., Walden, H., Schulman, B.A.
Deposit date:2009-06-11
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HU6
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX/BTB/3-BOX-PUCSBC1
Descriptor:Speckle-type POZ protein, Puckered
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-13
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3IVB
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-MACROH2ASBCPEP1
Descriptor:Speckle-type POZ protein, Core histone macro-H2A.1, ZINC ION, ...
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-08-31
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure 9
To be Published
3IVQ
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-CISBC2
Descriptor:Speckle-type POZ protein, CiSBC2
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3IVV
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-PUCSBC1_PEP1
Descriptor:Speckle-type POZ protein, PucSBC1
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
1YN6
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CRYSTAL STRUCTURE OF A MOUSE MHC CLASS I PROTEIN, H2-DB, IN COMPLEX WITH A PEPTIDE FROM THE INFLUENZA A ACID POLYMERASE
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Turner, S.J., Kedzierska, K., Komodromou, H., La Gruta, N.L., Dunstone, M.A., Webb, A.I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A.W., Rossjohn, J., Doherty, P.C.
Deposit date:2005-01-23
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
Nat.Immunol., 6, 2005
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