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3NY8
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGIC RECEPTOR IN COMPLEX WITH THE INVERSE AGONIST ICI 118,551
Descriptor:Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, ...
Authors:Wacker, D., Fenalti, G., Brown, M.A., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
4IB4
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CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT2B-BRIL IN COMPLEX WITH ERGOTAMINE
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, Ergotamine, PALMITIC ACID, ...
Authors:Wacker, D., Wang, C., Katritch, V., Han, G.W., Huang, X., Vardy, E., McCorvy, J.D., Jiang, Y., Chu, M., Siu, F.Y., Liu, W., Xu, H.E., Cherezov, V., Roth, B.L., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural features for functional selectivity at serotonin receptors.
Science, 340, 2013
5TVN
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CRYSTAL STRUCTURE OF THE LSD-BOUND 5-HT2B RECEPTOR
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL, ...
Authors:Wacker, D., Wang, S., McCorvy, J.D., Betz, R.M., Venkatakrishnan, A.J., Levit, A., Lansu, K., Schools, Z.L., Che, T., Nichols, D.E., Shoichet, B.K., Dror, R.O., Roth, B.L.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Cell, 168, 2017
3NY9
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGIC RECEPTOR IN COMPLEX WITH A NOVEL INVERSE AGONIST
Descriptor:Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, ...
Authors:Fenalti, G., Wacker, D., Brown, M.A., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
3NYA
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGIC RECEPTOR IN COMPLEX WITH THE NEUTRAL ANTAGONIST ALPRENOLOL
Descriptor:Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, ...
Authors:Brown, M.A., Wacker, D., Fenalti, G., Katritch, V., Abagyan, R., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
5WIU
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STRUCTURE OF THE HUMAN D4 DOPAMINE RECEPTOR IN COMPLEX WITH NEMONAPRIDE
Descriptor:D(4) dopamine receptor, soluble cytochrome b562 chimera, Nemonapride, ...
Authors:Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.
Deposit date:2017-07-20
Release date:2017-10-18
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.
Science, 358, 2017
5WIV
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STRUCTURE OF THE SODIUM-BOUND HUMAN D4 DOPAMINE RECEPTOR IN COMPLEX WITH NEMONAPRIDE
Descriptor:D(4) dopamine receptor, soluble cytochrome b562 chimera, Nemonapride, ...
Authors:Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.
Deposit date:2017-07-20
Release date:2017-10-18
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.143 Å)
Cite:D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.
Science, 358, 2017
4NC3
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CRYSTAL STRUCTURE OF THE 5-HT2B RECEPTOR SOLVED USING SERIAL FEMTOSECOND CRYSTALLOGRAPHY IN LIPIDIC CUBIC PHASE.
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, PALMITIC ACID, Ergotamine, ...
Authors:Liu, W., Wacker, D., Gati, C., Han, G.W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N.A., Li, D., Messerschmidt, M., Boutet, S., Williams, G.J., Koglin, J.E., Seibert, M.M., Wang, C., Shah, S.T.A., Basu, S., Fromme, R., Kupitz, C., Rendek, K.N., Grotjohann, I., Fromme, P., Kirian, R.A., Beyerlein, K.R., White, T.A., Chapman, H.N., Caffrey, M., Spence, J.C.H., Stevens, R.C., Cherezov, V., GPCR Network (GPCR)
Deposit date:2013-10-23
Release date:2013-12-18
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Serial femtosecond crystallography of G protein-coupled receptors.
Science, 342, 2013
4O9R
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HUMAN SMOOTHENED RECEPTOR STRUCTURE IN COMPLEX WITH CYCLOPAMINE
Descriptor:Smoothened homolog/Soluble cytochrome b562 chimeric protein, Cyclopamine
Authors:Wang, C., Weierstall, U., James, D., White, T.A., Wang, D., Liu, W., Spence, J.C.H., Doak, R.B., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N.A., Liu, H., Basu, S., Wacker, D., Han, G.W., Katritch, V., Boutet, S., Messerschmidt, M., Willams, G.J., Koglin, J.E., Seibert, M.M., Klinker, M., Gati, C., Shoeman, R.L., Barty, A., Chapman, H.N., Kirian, R.A., Beyerlein, K.R., Stevens, R.C., Li, D., Shah, S.T.A., Howe, N., Caffrey, M., Cherezov, V., GPCR Network (GPCR)
Deposit date:2014-01-02
Release date:2014-03-05
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (3.204 Å)
Cite:Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.
Nat Commun, 5, 2014
4L6R
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STRUCTURE OF THE CLASS B HUMAN GLUCAGON G PROTEIN COUPLED RECEPTOR
Descriptor:Soluble cytochrome b562 and Glucagon receptor chimera, DI(HYDROXYETHYL)ETHER
Authors:Siu, F.Y., He, M., de Graaf, C., Han, G.W., Yang, D., Zhang, Z., Zhou, C., Xu, Q., Wacker, D., Joseph, J.S., Liu, W., Lau, J., Cherezov, V., Katritch, V., Wang, M.W., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2013-06-12
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the human glucagon class B G-protein-coupled receptor.
Nature, 499, 2013
5TUD
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STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR RECOGNITION OF THE HUMAN SEROTONIN 2B RECEPTOR BY AN ANTIBODY
Descriptor:5-hydroxytryptamine receptor 2B,Soluble cytochrome b562 chimera, Anti-5-HT2B Fab light chain, Anti-5-HT2B Fab heavy chain, ...
Authors:Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G.W., Basu, S., Boutet, S., James, D., Wang, D., Weierstall, U., Liu, W., Katritch, V., Stevens, R.C., Cherezov, V.
Deposit date:2016-11-05
Release date:2017-07-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4DJH
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STRUCTURE OF THE HUMAN KAPPA OPIOID RECEPTOR IN COMPLEX WITH JDTIC
Descriptor:Kappa-type opioid receptor, Lysozyme, (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, ...
Authors:Wu, H., Wacker, D., Katritch, V., Mileni, M., Han, G.W., Vardy, E., Liu, W., Thompson, A.A., Huang, X.P., Carroll, F.I., Mascarella, S.W., Westkaemper, R.B., Mosier, P.D., Roth, B.L., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2012-02-01
Release date:2012-03-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:tructure of the human kappa-opioid receptor in complex with JDTic
Nature, 485, 2012
4IAQ
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CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH DIHYDROERGOTAMINE (PSI COMMUNITY TARGET)
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine
Authors:Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
4IAR
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CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH ERGOTAMINE (PSI COMMUNITY TARGET)
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
6B73
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CRYSTAL STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE KAPPA-OPIOID RECEPTOR
Descriptor:Soluble cytochrome b562, kappa-type opioid receptor, Nanobody, ...
Authors:Che, T., Majumdar, S., Zaidi, S.A., Kormos, C., McCorvy, J.D., Wang, S., Mosier, P.D., Uprety, R., Vardy, E., Krumm, B.E., Han, G.W., Lee, M.Y., Pardon, E., Steyaert, J., Huang, X.P., Strachan, R.T., Tribo, A.R., Pasternak, G.W., Carroll, I.F., Stevens, R.C., Cherezov, V., Katritch, V., Wacker, D., Roth, B.L.
Deposit date:2017-10-03
Release date:2018-01-17
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell, 172, 2018
6BQG
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH ERGOTAMINE
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6BQH
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH RITANSERIN
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6CM4
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STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE
Descriptor:D(2) dopamine receptor, endolysin chimera, 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, ...
Authors:Wang, S., Che, T., Levit, A., Shoichet, B.K., Wacker, D., Roth, B.L.
Deposit date:2018-03-02
Release date:2018-03-14
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.867 Å)
Cite:Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.
Nature, 555, 2018
6DRX
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DRY
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.918 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DRZ
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, CHOLESTEROL, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DS0
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, CHOLESTEROL, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.188 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
3F7F
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STRUCTURE OF NUP120
Descriptor:Nucleoporin NUP120, MERCURY (II) ION
Authors:Seo, H.S., Ma, Y., Debler, E.W., Blobel, G., Hoelz, A.
Deposit date:2008-11-08
Release date:2009-08-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
3H7N
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STRUCTURE OF NUP120
Descriptor:Nucleoporin NUP120
Authors:Seo, H.S., Ma, Y., Debler, E.W., Blobel, G., Hoelz, A.
Deposit date:2009-04-27
Release date:2009-08-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009