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2QZ9
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BU of 2qz9 by Molmil
crystal structure of aspartate semialdehyde dehydrogenase II from vibrio cholerae
Descriptor: Aspartate-semialdehyde dehydrogenase
Authors:Viola, R.E, Liu, X, Ohren, J.F, Faehnle, C.R.
Deposit date:2007-08-16
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.
Acta Crystallogr.,Sect.D, 64, 2008
2R00
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BU of 2r00 by Molmil
crystal structure of aspartate semialdehyde dehydrogenase II complexed with ASA from vibrio cholerae
Descriptor: 2,2'-oxydiacetic acid, Aspartate-semialdehyde dehydrogenase
Authors:Viola, R.E, Liu, X, Ohren, J.F, Faehnle, C.R.
Deposit date:2007-08-17
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.
Acta Crystallogr.,Sect.D, 64, 2008
1TB4
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BU of 1tb4 by Molmil
Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus influenzae with a Bound Periodate
Descriptor: Aspartate-semialdehyde dehydrogenase, PERIODATE
Authors:Viola, R.E.
Deposit date:2004-05-19
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
1TA4
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BU of 1ta4 by Molmil
Crystal Structure Of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with a Bound Arsenate
Descriptor: ARSENATE, Aspartate-semialdehyde dehydrogenase
Authors:Viola, R.E.
Deposit date:2004-05-19
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
3HSK
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BU of 3hsk by Molmil
Crystal Structure of Aspartate Semialdehyde Dehydrogenase with NADP from Candida albicans
Descriptor: Aspartate-semialdehyde dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Arachea, B.T, Pavlovsky, A, Liu, X, Viola, R.E.
Deposit date:2009-06-10
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog.
Acta Crystallogr.,Sect.D, 66, 2010
2YXP
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BU of 2yxp by Molmil
The Effect of Deuteration on Protein Structure A High Resolution Comparison of Hydrogenous and Perdeuterated Haloalkane Dehalogenase
Descriptor: Haloalkane dehalogenase
Authors:Liu, X, Hanson, L, Langan, P, Viola, R.E.
Deposit date:2007-04-27
Release date:2007-09-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase.
Acta Crystallogr.,Sect.D, 63, 2007
5JW6
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BU of 5jw6 by Molmil
Cystal structure of aspartate semialdehyde dehydrogenase from Aspergillus fumigatus
Descriptor: Aspartate-semialdehyde dehydrogenase, SULFATE ION
Authors:Dahal, G.P, Viola, R.E.
Deposit date:2016-05-11
Release date:2017-01-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus.
Acta Crystallogr F Struct Biol Commun, 73, 2017
1GL3
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BU of 1gl3 by Molmil
ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE IN COMPLEX WITH NADP AND SUBSTRATE ANALOGUE S-METHYL CYSTEINE SULFOXIDE
Descriptor: ASPARTATE-SEMIALDEHYDE DEHYDROGENASE, CYSTEINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Hadfield, A.T, Kryger, G, Ouyang, J, Ringe, D, Petsko, G.A, Viola, R.E.
Deposit date:2001-08-23
Release date:2001-11-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active Site Analysis of the Potential Antimicrobial Target Aspartate Semialdehyde Dehydrogenase.
Biochemistry, 40, 2001
6C8W
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BU of 6c8w by Molmil
Crystal structure of Aspartate Semialdehyde Dehydrogenase with NADP from Blastomyces dermatitidis
Descriptor: Aspartate-semialdehyde dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Dahal, G.P, Viola, R.E.
Deposit date:2018-01-25
Release date:2019-01-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Biochem.Biophys.Res.Commun., 503, 2018
6C07
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BU of 6c07 by Molmil
Crystal Structure of S-Adenosylmethionine synthetase (MetK/Mat) from Cryptosporidium parvum
Descriptor: CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Ohren, J.F, Viola, R.E.
Deposit date:2017-12-28
Release date:2019-01-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.
Acta Crystallogr F Struct Biol Commun, 75, 2019
6C85
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BU of 6c85 by Molmil
Crystal structure of aspartate semialdehyde dehydrogenase from Blastomyces dermatitidis with p-benzoquinone
Descriptor: 1,4-benzoquinone, Aspartate-semialdehyde dehydrogenase
Authors:Dahal, G.P, Viola, R.E.
Deposit date:2018-01-24
Release date:2019-01-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Biochem.Biophys.Res.Commun., 503, 2018
1IB6
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BU of 1ib6 by Molmil
CRYSTAL STRUCTURE OF R153C E. COLI MALATE DEHYDROGENASE
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Bell, J.K, Yennawar, H.P, Wright, S.K, Thompson, J.R, Viola, R.E, Banaszak, L.J.
Deposit date:2001-03-27
Release date:2001-09-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analyses of a Malate Dehydrogenase with a Variable Active Site
J.Biol.Chem., 276, 2001
1IE3
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BU of 1ie3 by Molmil
CRYSTAL STRUCTURE OF R153C E. COLI MALATE DEHYDROGENASE
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID
Authors:Bell, J.K, Yennawar, H.P, Wright, S.K, Thompson, J.R, Viola, R.E, Banaszak, L.J.
Deposit date:2001-04-05
Release date:2001-09-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analyses of a Malate Dehydrogenase with a Variable Active Site
J.Biol.Chem., 276, 2001
1KEQ
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BU of 1keq by Molmil
Crystal Structure of F65A/Y131C Carbonic Anhydrase V, covalently modified with 4-chloromethylimidazole
Descriptor: 4-METHYLIMIDAZOLE, ACETIC ACID, F65A/Y131C-MI Carbonic Anhydrase V, ...
Authors:Jude, K.M, Wright, S.K, Tu, C, Silverman, D.N, Viola, R.E, Christianson, D.W.
Deposit date:2001-11-16
Release date:2002-03-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
4LE5
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BU of 4le5 by Molmil
Structure of an Unusual S-adenosylmethionine synthetase from Campylobacter jejuni
Descriptor: S-adenosylmethionine synthetase
Authors:Zano, S.P, Pavlovsky, A.G, Viola, R.E.
Deposit date:2013-06-25
Release date:2014-02-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of an unusual S-adenosylmethionine synthetase from Campylobacter jejuni.
Acta Crystallogr.,Sect.D, 70, 2014
4MXU
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BU of 4mxu by Molmil
Human brain aspartoacylase mutant K213E complex with intermediate analog (N-phosphonomethyl-L-aspartate)
Descriptor: Aspartoacylase, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ZINC ION
Authors:Wijayasinghe, Y.S, Pavlovsky, A.G, Viola, R.E.
Deposit date:2013-09-26
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Aspartoacylase catalytic deficiency as the cause of canavan disease: a structural perspective.
Biochemistry, 53, 2014
4MRI
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BU of 4mri by Molmil
Human brain aspartoacylase mutant F295S complex with intermediate analog (N-phosphonomethyl-L-aspartate)
Descriptor: Aspartoacylase, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ZINC ION
Authors:Wijayasinghe, Y.S, Pavlovsky, A.G, Viola, R.E.
Deposit date:2013-09-17
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Aspartoacylase catalytic deficiency as the cause of canavan disease: a structural perspective.
Biochemistry, 53, 2014
4NFR
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BU of 4nfr by Molmil
Human brain aspartoacylase mutant E285A complex with intermediate analog (N-phosphonomethyl-L-aspartate)
Descriptor: Aspartoacylase, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ZINC ION
Authors:Wijayasinghe, Y.S, Pavlovsky, A.G, Viola, R.E.
Deposit date:2013-10-31
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Aspartoacylase catalytic deficiency as the cause of canavan disease: a structural perspective.
Biochemistry, 53, 2014
4R41
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BU of 4r41 by Molmil
Complex Crystal structure of 4-nitro-2-phosphono-benzoic acid with sp-Aspartate-Semialdehyde Dehydrogenase and Nicotinamide-dinucleotide
Descriptor: 1,2-ETHANEDIOL, 4-nitro-2-phosphonobenzoic acid, ACETATE ION, ...
Authors:Pavlovsky, A.G, Viola, R.E.
Deposit date:2014-08-18
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R4J
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BU of 4r4j by Molmil
Crystal structure of complex sp_ASADH with 3-carboxypropyl-phthalic acid and Nicotinamide Adenine dinucleotide phosphate
Descriptor: 1,2-ETHANEDIOL, 3-(3-carboxypropyl)benzene-1,2-dicarboxylic acid, Aspartate-semialdehyde dehydrogenase, ...
Authors:Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E.
Deposit date:2014-08-19
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R51
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BU of 4r51 by Molmil
Crystal complex structure of sp-Aspartate-Semialdehyde-Dehydrogenase with Nicotinamide Adenine dinucleotide phosphate and phthalic acid
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ...
Authors:Pavlovsky, A.G, Viola, R.E.
Deposit date:2014-08-20
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R3N
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BU of 4r3n by Molmil
Crystal structure of the ternary complex of sp-ASADH with NADP and 1,2,3-Benzenetricarboxylic acid
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ...
Authors:Pavlovsky, A.G, Viola, R.E.
Deposit date:2014-08-16
Release date:2014-12-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R5H
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BU of 4r5h by Molmil
Crystal structure of sp-Aspartate-Semialdehyde-Dehydrogenase with Nicotinamide-Adenine-Dinucleotide-Phosphate and 3-carboxy-propenyl-phthalic acid
Descriptor: 1,2-ETHANEDIOL, 3-[(1E)-3-carboxyprop-1-en-1-yl]benzene-1,2-dicarboxylic acid, Aspartate-semialdehyde dehydrogenase, ...
Authors:Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E.
Deposit date:2014-08-21
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R3W
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BU of 4r3w by Molmil
Crystal Structure Analysis of the 1,2,3-tricarboxylate benzoic acid bound to sp-ASADH-2'5'-ADP complex
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-2'-5'-DIPHOSPHATE, ...
Authors:Pavlovsky, A.G, Viola, R.E.
Deposit date:2014-08-18
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R5M
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BU of 4r5m by Molmil
Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid
Descriptor: 4-nitro-2-phosphonobenzoic acid, Aspartate-semialdehyde dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E.
Deposit date:2014-08-21
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014

 

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