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2I42
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CRYSTAL STRUCTURE OF YERSINIA PROTEIN TYROSINE PHOSPHATASE COMPLEXED WITH VANADATE, A TRANSITION STATE ANALOGUE
Descriptor:Tyrosine-protein phosphatase, VANADATE ION
Authors:Vijayalakshmi, J., Saper, M.A.
Deposit date:2006-08-21
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Yersinia protein tyrosine phosphatase complexed with vanadate, a transition state analogue
To be Published
3CKM
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LPOA (YRAM) C-DOMAIN FROM HAEMOPHILUS INFLUENZAE, A REGULATOR OF PBP1A
Descriptor:YRAM (HI1655), SULFATE ION, BETA-MERCAPTOETHANOL
Authors:Vijayalakshmi, J., Saper, M.A.
Deposit date:2008-03-16
Release date:2008-05-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of YraM, a protein essential for growth of Haemophilus influenzae.
Proteins, 73, 2008
1HW7
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HSP33, HEAT SHOCK PROTEIN WITH REDOX-REGULATED CHAPERONE ACTIVITY
Descriptor:HEAT SHOCK PROTEIN HSP33, SULFATE ION, ZINC ION, ...
Authors:Vijayalakshmi, J., Mukhergee, M.K., Graumann, J., Jakob, U., Saper, M.A.
Deposit date:2001-01-09
Release date:2001-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2 A crystal structure of Hsp33: a heat shock protein with redox-regulated chaperone activity.
Structure, 9, 2001
3F1K
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CRYSTAL STRUCTURE OF YCIK FROM E. COLI, AN OXIDOREDUCTASE, COMPLEXED WITH NADP+ AT 2.6A RESOLUTION
Descriptor:Uncharacterized oxidoreductase yciK, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Vijayalakshmi, J., Woodard, R.W.
Deposit date:2008-10-28
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an oxidoreductase, yciK from E. coli, in two crystal forms - NADP+ unbound structure at 0.95 A resolution
to be published
3F1L
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THE 0.95 A STRUCTURE OF AN OXIDOREDUCTASE, YCIK FROM E.COLI
Descriptor:Uncharacterized oxidoreductase yciK
Authors:Vijayalakshmi, J., Woodard, R.W.
Deposit date:2008-10-28
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structure of an oxidoreductase, yciK from E. coli, in two crystal forms - NADP+ unbound structure at 0.95 A resolution
to be published
3F4W
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THE 1.65A CRYSTAL STRUCTURE OF 3-HEXULOSE-6-PHOSPHATE SYNTHASE FROM SALMONELLA TYPHIMURIUM
Descriptor:Putative hexulose 6 phosphate synthase, MALONATE ION
Authors:Vijayalakshmi, J., Woodard, R.W.
Deposit date:2008-11-03
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The 1.65A Crystal Structure of 3-hexulose-6-phosphate synthase from Salmonella typhimurium
To be Published
4P29
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CRYSTAL STRUCTURE OF THE LPOA N-TERMINAL DOMAIN FROM HAEMOPHILUS INFLUENZAE
Descriptor:LpoA, SULFATE ION, GLYCEROL, ...
Authors:Vijayalakshmi, J., Saper, M.A.
Deposit date:2014-03-02
Release date:2015-03-04
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.950065 Å)
Cite:Structural analyses of the Haemophilus influenzae peptidoglycan synthase activator LpoA suggest multiple conformations in solution
J.Biol.Chem., 2017
6DCJ
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LPOA N-TERMINAL DOMAIN FROM HAEMOPHILUS INFLUENZAE; MONOCLINIC FORM AT 1.35 A RESOLUTION
Descriptor:Penicillin-binding protein activator LpoA, CHLORIDE ION
Authors:Vijayalakshmi, J., Saper, M.A.
Deposit date:2018-05-07
Release date:2019-05-01
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structures of the amino-terminal domain of LpoA from Escherichia coli and Haemophilus influenzae.
Acta Crystallogr.,Sect.F, 75, 2019
1HAG
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THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
Descriptor:PRETHROMBIN 2, HIRUGEN, N-ACETYL-D-GLUCOSAMINE
Authors:Tulinsky, A., Vijayalakshmi, J.
Deposit date:1994-06-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Protein Sci., 3, 1994
1HAH
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THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ...
Authors:Tulinsky, A., Vijayalakshmi, J.
Deposit date:1994-06-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Protein Sci., 3, 1994
1HAI
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THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
Authors:Tulinsky, A., Vijayalakshmi, J.
Deposit date:1994-06-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Protein Sci., 3, 1994
9EST
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STRUCTURAL STUDY OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH 7-AMINO-3-(2-BROMOETHOXY)-4-CHLOROISOCOUMARIN AS A NONREACTIVATABLE DOUBLY COVALENT ENZYME-INHIBITOR COMPLEX
Descriptor:PORCINE PANCREATIC ELASTASE, SULFATE ION, CALCIUM ION, ...
Authors:Radhakrishnan, R., Powers, J.C., Meyer Jr., E.F.
Deposit date:1991-01-14
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex.
Biochemistry, 30, 1991
1NES
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STRUCTURE OF THE PRODUCT COMPLEX OF ACETYL-ALA-PRO-ALA WITH PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION
Descriptor:ELASTASE, ACETYL-ALA-PRO-ALA, CALCIUM ION, ...
Authors:Meyer Junior, E.F., Radhakrishnan, R., M Cole, G., Presta, L.G.
Deposit date:1995-07-31
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution.
J.Mol.Biol., 189, 1986
8EST
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REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH 4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN
Descriptor:PORCINE PANCREATIC ELASTASE, SULFATE ION, CALCIUM ION, ...
Authors:Radhakrishnan, R., Powers, J.C., Meyerjunior, E.F.
Deposit date:1990-02-21
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.
Biochemistry, 29, 1990
5KCN
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CRYSTAL STRUCTURE OF FULL-LENGTH LPOA FROM HAEMOPHILUS INFLUENZAE AT 1.97 ANGSTROM RESOLUTION
Descriptor:Penicillin-binding protein activator LpoA, CHLORIDE ION
Authors:Sathiyamoorthy, K., Saper, M.A.
Deposit date:2016-06-06
Release date:2017-09-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.965 Å)
Cite:Structural analyses of the Haemophilus influenzae peptidoglycan synthase activator LpoA suggest multiple conformations in solution.
J. Biol. Chem., 292, 2017
5VAT
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HAEMOPHILUS INFLUENZAE LPOA: MONOCLINIC FORM (MON2) WITH 2 MOLECULES PER A.U.
Descriptor:Penicillin-binding protein activator LpoA
Authors:Saper, M.A., Sathiyamoorthy, K.
Deposit date:2017-03-27
Release date:2017-09-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analyses of the Haemophilus influenzae peptidoglycan synthase activator LpoA suggest multiple conformations in solution.
J. Biol. Chem., 292, 2017
5VBG
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CRYSTAL STRUCTURE OF FULL-LENGTH LPOA, MONOCLINIC FORM 1, FROM HAEMOPHILUS INFLUENZAE
Descriptor:Penicillin-binding protein activator LpoA, CHLORIDE ION
Authors:Sathiyamoorthy, K., Saper, M.A.
Deposit date:2017-03-29
Release date:2017-09-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analyses of the Haemophilus influenzae peptidoglycan synthase activator LpoA suggest multiple conformations in solution.
J. Biol. Chem., 292, 2017
6DR3
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CRYSTAL STRUCTURE OF E. COLI LPOA AMINO TERMINAL DOMAIN
Descriptor:Penicillin-binding protein activator LpoA
Authors:Kelley, A.C., Saper, M.A.
Deposit date:2018-06-11
Release date:2019-05-08
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Crystal structures of the amino-terminal domain of LpoA from Escherichia coli and Haemophilus influenzae.
Acta Crystallogr.,Sect.F, 75, 2019
1EAS
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NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES
Descriptor:PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ...
Authors:Ceccarelli, C.
Deposit date:1994-11-22
Release date:1995-02-07
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
J.Med.Chem., 37, 1994
1EAT
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NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES
Descriptor:PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ...
Authors:Ceccarelli, C.
Deposit date:1994-11-22
Release date:1995-02-07
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
J.Med.Chem., 38, 1995
1EAU
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NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 6. DESIGN OF A POTENT, INTRATRACHEALLY ACTIVE, PYRIDONE-BASED TRIFLUOROMETHYL KETONE
Descriptor:PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ...
Authors:Ceccarelli, C.
Deposit date:1994-11-22
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone.
J.Med.Chem., 38, 1995
1MKW
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1MKX
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1A4W
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CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ...
Authors:Matthews, J.H., Krishnan, R., Costanzo, M.J., Maryanoff, B.E., Tulinsky, A.
Deposit date:1998-02-06
Release date:1998-04-29
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.
Biophys.J., 71, 1996
1HXF
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HUMAN THROMBIN COMPLEX WITH HIRUDIN VARIANT
Descriptor:THROMBIN, HIRUDIN VARIANT
Authors:Tulinsky, A., Zhang, E.
Deposit date:1996-09-09
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The molecular environment of the Na+ binding site of thrombin.
Biophys.Chem., 63, 1997
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