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4C0R
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BU of 4c0r by Molmil
Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans.
Descriptor: CADMIUM ION, CHLORIDE ION, OXIDIZED GLUTATHIONE DISULFIDE, ...
Authors:Vergauwen, B, Verstraete, K, Senadheera, D.B, Dansercoer, A, Cvitkovitch, D.G, Guedon, E, Savvides, S.N.
Deposit date:2013-08-07
Release date:2013-08-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.547 Å)
Cite:Molecular and Structural Basis of Glutathione Import in Gram-Positive Bacteria Via Gsht and the Cystine Abc Importer Tcybc of Streptococcus Mutans.
Mol.Microbiol., 89, 2013
3M8U
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BU of 3m8u by Molmil
Crystal structure of glutathione-binding protein A (GbpA) from Haemophilus parasuis SH0165 in complex with glutathione disulfide (GSSG)
Descriptor: Heme-binding protein A, MALONATE ION, OXIDIZED GLUTATHIONE DISULFIDE
Authors:Vergauwen, B, Elegheert, J, Dansercoer, A, Devreese, B, Savvides, S.N.
Deposit date:2010-03-19
Release date:2010-07-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA
Proc.Natl.Acad.Sci.USA, 107, 2010
3TPA
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BU of 3tpa by Molmil
Structure of HbpA2 from Haemophilus parasuis
Descriptor: Heme-binding protein A
Authors:Vergauwen, B, Van der Meeren, R, Dansercoer, A, Savvides, S.N.
Deposit date:2011-09-07
Release date:2011-11-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.0001 Å)
Cite:Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins.
Bmc Biochem., 12, 2011
2RAB
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BU of 2rab by Molmil
Structure of glutathione amide reductase from Chromatium gracile in complex with NAD
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, NICKEL (II) ION, ...
Authors:Van Petegem, F, De Vos, D, Savvides, S, Vergauwen, B, Van Beeumen, J.
Deposit date:2007-09-14
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase.
J.Mol.Biol., 374, 2007
2R9Z
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BU of 2r9z by Molmil
Glutathione amide reductase from Chromatium gracile
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Glutathione amide reductase, ...
Authors:Van Petegem, F, Vergauwen, B, Savvides, S, De Vos, D, Van Beeumen, J.
Deposit date:2007-09-14
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase.
J.Mol.Biol., 374, 2007
3LN7
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BU of 3ln7 by Molmil
Crystal structure of a bifunctional glutathione synthetase from Pasteurella multocida
Descriptor: Glutathione biosynthesis bifunctional protein gshAB
Authors:Stout, J, Vergauwen, B, Savvides, S.N.
Deposit date:2010-02-02
Release date:2011-04-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of two bifunctional gamma-Glutamate-cysteine Ligase/Glutathione synthetases (GshF) reveal a novel hybrid ATP-grasp fold
To be Published
3LN6
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BU of 3ln6 by Molmil
Crystal structure of a bifunctional glutathione synthetase from Streptococcus agalactiae
Descriptor: Glutathione biosynthesis bifunctional protein gshAB, SULFATE ION
Authors:Stout, J, Vergauwen, B, Savvides, S.N.
Deposit date:2010-02-02
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structures of two bifunctional gamma-Glutamate-cysteine Ligase/Glutathione synthetases (GshF) reveal a novel hybrid ATP-grasp fold
To be Published
4PU8
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BU of 4pu8 by Molmil
Shewanella oneidensis Toxin Antitoxin System Antitoxin Protein HipB Resolution 2.35
Descriptor: Toxin-antitoxin system antidote transcriptional repressor Xre family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU3
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BU of 4pu3 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P212121)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU5
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BU of 4pu5 by Molmil
Shewanella oneidensis Toxin Antitoxin System Toxin Protein HipA Bound with AMPPNP and Mg
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ...
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.834 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU4
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BU of 4pu4 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P21)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.786 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU7
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BU of 4pu7 by Molmil
Shewanella oneidensis Toxin Antitoxin System Antitoxin Protein HipB Resolution 1.85
Descriptor: Toxin-antitoxin system antidote transcriptional repressor Xre family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
3UCE
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BU of 3uce by Molmil
Crystal structure of a small-chain dehydrogenase in complex with NADPH
Descriptor: Dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Buysschaert, G, Verstraete, K, Savvides, S, Vergauwen, B.
Deposit date:2011-10-26
Release date:2012-11-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference.
Febs J., 280, 2013
3UCF
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BU of 3ucf by Molmil
Crystal structure of a small-chain dehydrogenase
Descriptor: Dehydrogenase
Authors:Buysschaert, G, Verstraete, K, Savvides, S, Vergauwen, B.
Deposit date:2011-10-26
Release date:2013-01-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.347 Å)
Cite:Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference.
Febs J., 280, 2013
2BE7
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BU of 2be7 by Molmil
Crystal structure of the unliganded (T-state) aspartate transcarbamoylase of the psychrophilic bacterium Moritella profunda
Descriptor: Aspartate Carbamoyltransferase Catalytic Chain, Aspartate Carbamoyltransferase Regulatory Chain, SULFATE ION, ...
Authors:De Vos, D, Savvides, S.N, Van Beeumen, J.
Deposit date:2005-10-23
Release date:2006-10-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural investigation of cold activity and regulation of aspartate carbamoyltransferase from the extreme psychrophilic bacterium Moritella profunda.
J.Mol.Biol., 365, 2007
3QS9
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BU of 3qs9 by Molmil
Crystal structure of a human Flt3 ligand-receptor ternary complex
Descriptor: FL cytokine receptor, SL cytokine
Authors:Verstraete, K, Savvides, S.N.
Deposit date:2011-02-20
Release date:2011-03-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (7.8 Å)
Cite:Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
Blood, 118, 2011
3QS7
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BU of 3qs7 by Molmil
Crystal structure of a human Flt3 ligand-receptor ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FL cytokine receptor, SL cytokine
Authors:Verstraete, K, Savvides, S.N.
Deposit date:2011-02-19
Release date:2011-03-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
Blood, 118, 2011
5D28
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BU of 5d28 by Molmil
Complex of GM-CSF/IL-2 inhibition factor with Granulocyte-macrophage colony-stimulating factor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GM-CSF/IL-2 inhibition factor, ...
Authors:Felix, J, Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
5D22
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BU of 5d22 by Molmil
Structure of ovine granulocyte-macrophage colony-stimulating factor
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Granulocyte-macrophage colony-stimulating factor
Authors:Felix, J, Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
8C7L
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BU of 8c7l by Molmil
Serendipitous structure of OmpF contaminant in space group P21.
Descriptor: Outer membrane porin F
Authors:Bloch, Y, Theunissen, S, Savvides, S.N.
Deposit date:2023-01-16
Release date:2023-02-22
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:Serendipitous structure of OmpF contaminant in space group P21.
To Be Published
3UF2
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BU of 3uf2 by Molmil
Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine
Descriptor: Macrophage colony-stimulating factor 1
Authors:Elegheert, J, Savvides, S.N.
Deposit date:2011-10-31
Release date:2012-08-22
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Nat.Struct.Mol.Biol., 19, 2012
3UF5
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BU of 3uf5 by Molmil
Crystal structure of the mouse Colony-Stimulating Factor 1 (mCSF-1) cytokine
Descriptor: CALCIUM ION, Macrophage colony-stimulating factor 1
Authors:Elegheert, J, Bracke, N, Bekaert, A, Savvides, S.N.
Deposit date:2011-10-31
Release date:2012-08-22
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Nat.Struct.Mol.Biol., 19, 2012
3UEZ
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BU of 3uez by Molmil
Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the viral receptor BARF1
Descriptor: Macrophage colony-stimulating factor 1, Secreted protein BARF1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Elegheert, J, Bracke, N, Savvides, S.N.
Deposit date:2011-10-31
Release date:2012-08-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.414 Å)
Cite:Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Nat.Struct.Mol.Biol., 19, 2012
4ADQ
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BU of 4adq by Molmil
CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1
Descriptor: MACROPHAGE COLONY-STIMULATING FACTOR 1, SECRETED PROTEIN BARF1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Elegheert, J, Bracke, N, Savvides, S.N.
Deposit date:2012-01-02
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Allosteric Competitive Inactivation of Hematopoietic Csf-1 Signaling by the Viral Decoy Receptor Barf1.
Nat.Struct.Mol.Biol., 19, 2012
4ADF
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BU of 4adf by Molmil
CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1
Descriptor: MACROPHAGE COLONY-STIMULATING FACTOR 1, SECRETED PROTEIN BARF1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Elegheert, J, Bracke, N, Savvides, S.N.
Deposit date:2011-12-23
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Allosteric Competitive Inactivation of Hematopoietic Csf-1 Signaling by the Viral Decoy Receptor Barf1.
Nat.Struct.Mol.Biol., 19, 2012

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