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7ZIR
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BU of 7zir by Molmil
Cryo-EM structure of hnRNPDL amyloid fibrils
Descriptor: Heterogeneous nuclear ribonucleoprotein D-like
Authors:Garcia-Pardo, J, Chaves-Sanjuan, A, Bartolome-Nafria, A, Gil-Garcia, M, Visentin, C, Bolognesi, M, Ricagno, S, Ventura, S.
Deposit date:2022-04-08
Release date:2022-12-28
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3.
Nat Commun, 14, 2023
8BQ3
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BU of 8bq3 by Molmil
Crystal structure of human R13 mutant of the c-Src SH3 domain in complex with VSL12-peptide
Descriptor: PRO-LEU-PRO, Proto-oncogene tyrosine-protein kinase Src
Authors:Varejao, N, Navarro, S, Ventura, S, Reverter, D.
Deposit date:2022-11-18
Release date:2023-11-29
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Crystal structure of human R13 mutant of the c-Src SH3 domain in complex with VSL12-peptide
To Be Published
6XTK
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BU of 6xtk by Molmil
Y114C Transthyretin structure in complex with Tolcalpone
Descriptor: Tolcapone, Transthyretin
Authors:Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
Deposit date:2020-01-16
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
6RO9
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BU of 6ro9 by Molmil
Human spectrin SH3 domain D48G, E7V, K60V
Descriptor: Spectrin alpha, non-erythrocytic 1
Authors:Reverter, D, Navarro, S, Ventura, S.
Deposit date:2019-05-10
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.814 Å)
Cite:Human spectrin SH3 domain D48G, E7V, K60V
To Be Published
6TXW
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BU of 6txw by Molmil
V30G Transthyretin structure in complex with Tolcalpone
Descriptor: Tolcapone, Transthyretin
Authors:Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
Deposit date:2020-01-14
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.153 Å)
Cite:Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
6TXV
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BU of 6txv by Molmil
A25T Transthyretin structure in complex with Tolcalpone
Descriptor: Tolcapone, Transthyretin
Authors:Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
Deposit date:2020-01-14
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
1H20
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BU of 1h20 by Molmil
Solution structure of the potato carboxypeptidase inhibitor
Descriptor: METALLOCARBOXYPEPTIDASE INHIBITOR
Authors:Gonzalez, C, Neira, J.L, Ventura, S, Bronsoms, S, Aviles, F.X, Rico, M.
Deposit date:2002-07-29
Release date:2003-05-09
Last modified:2011-12-28
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Potato Carboxypeptidase Inhibitor by 1H and 15N NMR.
Proteins, 50, 2003
2V77
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BU of 2v77 by Molmil
Crystal Structure of Human Carboxypeptidase A1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBOXYPEPTIDASE A1, OCTANE-1,3,5,7-TETRACARBOXYLIC ACID, ...
Authors:Pallares, I, Fernandez, D, Comellas-Bigler, M, Fernandez-Recio, J, Ventura, S, Aviles, F.X, Vendrell, J.
Deposit date:2007-07-27
Release date:2008-07-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).
Acta Crystallogr. D Biol. Crystallogr., D64, 2008
7QC5
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BU of 7qc5 by Molmil
Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound
Descriptor: (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone, Transthyretin
Authors:Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
Deposit date:2021-11-22
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
J.Med.Chem., 65, 2022
6FWW
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BU of 6fww by Molmil
GFP/KKK. A redesigned GFP with improved solubility
Descriptor: Green fluorescent protein
Authors:Varejao, N, Lascorz, J, Gil-Garcia, M, Diaz-Caballero, M, Navarro, S, Ventura, S, Reverter, D.
Deposit date:2018-03-07
Release date:2018-08-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.131 Å)
Cite:Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility.
Mol. Pharm., 15, 2018
2ABZ
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BU of 2abz by Molmil
Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Descriptor: Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L, Popowicz, G.M, Bronsoms, S, Aviles, F.X, Huber, R, Holak, T.A, Ventura, S.
Deposit date:2005-07-18
Release date:2006-01-31
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
1ZFL
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BU of 1zfl by Molmil
Solution structure of III-A, the major intermediate in the oxidative folding of leech carboxypeptidase inhibitor
Descriptor: Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
5A6I
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BU of 5a6i by Molmil
V122I Transthyretin structure in complex with Tolcalpone
Descriptor: TRANSTHYRETIN, Tolcapone
Authors:Reverter, D, Gallego, P, Santana, R, Ventura, S.
Deposit date:2015-06-26
Release date:2016-02-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016
5AEK
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BU of 5aek by Molmil
Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W
Descriptor: SENTRIN-SPECIFIC PROTEASE 2, SMALL UBIQUITIN-RELATED MODIFIER 1
Authors:Gallego, P, Grana-Montes, R, Espargaro, A, Castillo, V, Torrent, J, Lange, R, Papaleo, E, Lindorff-Larsend, K, Ventura, S, Reverter, D.
Deposit date:2014-12-23
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Stepping Back and Forward on Sumo Folding Evolution
To be Published
5AQ0
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BU of 5aq0 by Molmil
The structure of the Transthyretin-like domain of the first catalytic domain of the HUMAN Carboxypeptidase D
Descriptor: CARBOXYPEPTIDASE D, GLYCEROL
Authors:Gallego, P, Garcia-Pardo, J, Lorenzo, J, Aviles, F.X, Ventura, S, Reverter, D.
Deposit date:2015-09-18
Release date:2016-09-28
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:The Structure of the Ttldomain of the Human Carboxypeptidase D
To be Published
2BOA
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BU of 2boa by Molmil
Human procarboxypeptidase A4.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBOXYPEPTIDASE A4, ...
Authors:Garcia-Castellanos, R, Bonet-Figueredo, R, Pallares, I, Ventura, S, Aviles, F.X, Vendrell, J, Gomis-Ruth, F.X.
Deposit date:2005-04-08
Release date:2005-12-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Detailed Molecular Comparison between the Inhibition Mode of A/B-Type Carboxypeptidases in the Zymogen State and by the Endogenous Inhibitor Latexin.
Cell.Mol.Life Sci., 62, 2005
5FWB
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BU of 5fwb by Molmil
Human Spectrin SH3 domain D48G, E7F, K60F
Descriptor: SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1
Authors:Gallego, P, Navarro, S, Ventura, S, Reverter, D.
Deposit date:2016-02-12
Release date:2016-12-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Human Spectrin SH3 Domain D48G, E7F, K60F
To be Published
5FW9
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BU of 5fw9 by Molmil
Human Spectrin SH3 domain D48G, E7Y, K60Y
Descriptor: SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1
Authors:Gallego, P, Navarro, S, Ventura, S, Reverter, D.
Deposit date:2016-02-12
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Human Spectrin SH3 Domain D48G, E7Y, K60Y
To be Published
5FWC
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BU of 5fwc by Molmil
Human Spectrin SH3 domain D48G, E7A, K60A
Descriptor: 1,2-ETHANEDIOL, AMMONIUM ION, SPECTRIN ALPHA CHAIN, ...
Authors:Gallego, P, Navarro, S, Ventura, S, Reverter, D.
Deposit date:2016-02-12
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Human Spectrin SH3 Domain D48G, E7A, K60A
To be Published
6FXU
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BU of 6fxu by Molmil
Crystal structure of human transthyretin mutant T119M at pH 5.5
Descriptor: Transthyretin
Authors:Varejao, N, Esperante, S, Ventura, S, Reverter, D.
Deposit date:2018-03-09
Release date:2019-03-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.359 Å)
Cite:Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J.Biol.Chem., 297, 2021
6FZL
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BU of 6fzl by Molmil
Crystal structure of human transthyretin double mutant K35T/T119M
Descriptor: Transthyretin
Authors:Esperante, S, Ventura, S, Reverter, D, Varejao, N.
Deposit date:2018-03-15
Release date:2019-03-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.446 Å)
Cite:Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J.Biol.Chem., 297, 2021
6FWD
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BU of 6fwd by Molmil
Crystal structure of human transthyretin double mutant R34G/T119M at pH 5.5
Descriptor: Transthyretin
Authors:Esperante, S, Ventura, S, Reverter, D, Varejao, N.
Deposit date:2018-03-06
Release date:2019-03-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.576 Å)
Cite:Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J.Biol.Chem., 297, 2021
5FW6
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BU of 5fw6 by Molmil
Structure of human transthyretin mutant A108V
Descriptor: TRANSTHYRETIN
Authors:Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
Deposit date:2016-02-12
Release date:2017-03-08
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
5FO2
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BU of 5fo2 by Molmil
Structure of human transthyretin mutant A108I
Descriptor: TRANSTHYRETIN
Authors:Varejao, N, Santanna, R, Saraiva, M.J, Gallego, P, Ventura, S, Reverter, D.
Deposit date:2015-11-17
Release date:2016-11-30
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.449 Å)
Cite:Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
4D7B
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BU of 4d7b by Molmil
Structure of human transthyretin in complex with Tolcapone
Descriptor: TRANSTHYRETIN, Tolcapone
Authors:Gallego, P, Sant'anna, R.O, Ventura, S, Reverter, D.
Deposit date:2014-11-21
Release date:2016-01-20
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016

 

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