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4E26
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BRAF IN COMPLEX WITH AN ORGANIC INHIBITOR 7898734
Descriptor:Serine/threonine-protein kinase B-raf, 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol
Authors:Qin, J., Xie, P., Ventocilla, C., Zhou, G., Vultur, A., Chen, Q., Herlyn, M., Winkler, J., Marmorstein, R.
Deposit date:2012-03-07
Release date:2012-05-09
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012
5EP0
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QUORUM-SENSING SIGNAL INTEGRATOR LUXO - RECEIVER+CATALYTIC DOMAINS
Descriptor:Putative repressor protein luxO, SULFATE ION, 1,2-ETHANEDIOL
Authors:Shah, T., Selcuk, H.B., Jeffrey, P.D., Hughson, F.M.
Deposit date:2015-11-11
Release date:2016-04-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
5EP1
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QUORUM-SENSING SIGNAL INTEGRATOR LUXO - CATALYTIC DOMAIN
Descriptor:Putative repressor protein luxO, ACETATE ION
Authors:Shah, T., Selcuk, H.B., Jeffrey, P.D., Hughson, F.M.
Deposit date:2015-11-11
Release date:2016-04-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
5EP2
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QUORUM-SENSING SIGNAL INTEGRATOR LUXO - CATALYTIC DOMAIN IN COMPLEX WITH AZAU INHIBITOR
Descriptor:Putative repressor protein luxO, 2,2-dimethylpropyl 2-[[3,5-bis(oxidanylidene)-2~{H}-1,2,4-triazin-6-yl]sulfanyl]ethanoate, ACETATE ION
Authors:Shah, T., Selcuk, H.B., Jeffrey, P.D., Hughson, F.M.
Deposit date:2015-11-11
Release date:2016-04-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.421 Å)
Cite:Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
5EP3
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QUORUM-SENSING SIGNAL INTEGRATOR LUXO - CATALYTIC DOMAIN BOUND TO CV-133 INHIBITOR
Descriptor:Putative repressor protein luxO, 2,2-dimethylpropyl 2-[(3-oxidanylidene-5-sulfanylidene-2~{H}-1,2,4-triazin-6-yl)amino]ethanoate, SULFATE ION, ...
Authors:Shah, T., Selcuk, H.B., Jeffrey, P.D., Hughson, F.M.
Deposit date:2015-11-11
Release date:2016-04-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
5EP4
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STRUCTURE, REGULATION, AND INHIBITION OF THE QUORUM-SENSING SIGNAL INTEGRATOR LUXO
Descriptor:Putative repressor protein luxO, ADENOSINE-5'-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Shah, T., Selcuk, H.B., Jeffrey, P.D., Hughson, F.M.
Deposit date:2015-11-11
Release date:2016-04-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
5JRQ
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BRAFV600E KINASE DOMAIN IN COMPLEX WITH CHEMICALLY LINKED VEMURAFENIB INHIBITOR VEM-6-VEM
Descriptor:Serine/threonine-protein kinase B-raf, (3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methanone, DIMETHYL SULFOXIDE, ...
Authors:Grasso, M.J., Marmorstein, R.
Deposit date:2016-05-06
Release date:2016-09-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.287 Å)
Cite:Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Acs Chem.Biol., 11, 2016
5JSM
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BRAFV600E KINASE DOMAIN IN COMPLEX WITH CHEMICALLY LINKED VEMURAFENIB INHIBITOR VEM-3-VEM
Descriptor:Serine/threonine-protein kinase B-raf, DIMETHYL SULFOXIDE, BENZAMIDINE, ...
Authors:Grasso, M.J., Marmorstein, R.
Deposit date:2016-05-08
Release date:2016-09-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Acs Chem.Biol., 11, 2016
5JT2
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BRAFV600E KINASE DOMAIN IN COMPLEX WITH CHEMICALLY LINKED VEMURAFENIB INHIBITOR VEM-BISAMIDE
Descriptor:Serine/threonine-protein kinase B-raf, BENZAMIDINE, 2,2'-oxybis[N-({4-[3-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorobenzene-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methyl)acetamide]
Authors:Grasso, M.J., Marmorstein, R.
Deposit date:2016-05-09
Release date:2016-09-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Acs Chem.Biol., 11, 2016