Author results

1BAY
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GLUTATHIONE S-TRANSFERASE YFYF CYS 47-CARBOXYMETHYLATED CLASS PI, FREE ENZYME
Descriptor:GLUTATHIONE S-TRANSFERASE CLASS PI
Authors:Vega, M.C., Coll, M.
Deposit date:1996-11-02
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.
J.Biol.Chem., 273, 1998
1GTI
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MODIFIED GLUTATHIONE S-TRANSFERASE (PI) COMPLEXED WITH S (P-NITROBENZYL)GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE, S-(P-NITROBENZYL)GLUTATHIONE
Authors:Vega, M.C., Coll, M.
Deposit date:1998-01-09
Release date:1999-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.
J.Biol.Chem., 273, 1998
1QKW
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ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, N47G MUTANT IN THE DISTAL LOOP.
Descriptor:ALPHA II SPECTRIN, SULFATE ION, GLYCEROL
Authors:Vega, M.C., Martinez, J., Serrano, L.
Deposit date:1999-08-16
Release date:2000-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Thermodynamic and Structural Characterization of Asn and Ala Residues in the Disallowed II' Region of the Ramachandran Plot
Protein Sci., 9, 2000
1QKX
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ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, N47A MUTANT IN THE DISTAL LOOP.
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Vega, M.C., Martinez, J., Serrano, L.
Deposit date:1999-08-16
Release date:2000-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Thermodynamic and Structural Characterization of Asn and Ala Residues in the Disallowed II' Region of the Ramachandran Plot
Protein Sci., 9, 2000
1USY
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ATP PHOSPHORIBOSYL TRANSFERASE (HISG:HISZ) COMPLEX FROM THERMOTOGA MARITIMA
Descriptor:ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SUBUNIT, ATP PHOSPHORIBOSYLTRANSFERASE, HISTIDINE, ...
Authors:Vega, M.C., Fernandez, F.J., Murphy, G.E., Zou, P., Popov, A., Wilmanns, M.
Deposit date:2003-12-01
Release date:2004-12-15
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Regulation of the Hetero-Octameric ATP Phosphoribosyl Transferase Complex from Thermotoga Maritima by a tRNA Synthetase-Like Subunit.
Mol.Microbiol., 55, 2005
264D
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THREE-DIMENSIONAL CRYSTAL STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR-GROOVE-BINDING DRUG HOECHST 33258
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
Authors:Vega, M.C., Garcia-Saez, I., Aymami, J., Eritja, R., Van Der Marel, G.A., Van Boom, J.H., Rich, A., Coll, M.
Deposit date:1994-09-22
Release date:1995-03-31
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Three-dimensional crystal structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor-groove-binding drug Hoechst 33258.
Eur.J.Biochem., 222, 1994
3ZR4
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STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA-ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX
Descriptor:IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH, GLYCEROL, ...
Authors:Vega, M.C., Kuper, J., Haeger, M.C., Mohrlueder, J., Marquardt, S., Sterner, R., Wilmanns, M.
Deposit date:2011-06-13
Release date:2012-10-03
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Chem.Biol., 19, 2012
2WJZ
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CRYSTAL STRUCTURE OF (HISH) K181A Y138A MUTANT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE (HISH HISF) WHICH DISPLAYS CONSTITUTIVE GLUTAMINASE ACTIVITY
Descriptor:IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISF, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH, PHOSPHATE ION
Authors:Vega, M.C., List, F., Razeto, A., Haeger, M.C., Babinger, K., Kuper, J., Sterner, R., Wilmanns, M.
Deposit date:2009-06-02
Release date:2010-08-25
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Chem.Biol., 19, 2012
1E6G
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A-SPECTRIN SH3 DOMAIN A11V, V23L, M25I, V53I, V58L MUTANT
Descriptor:SPECTRIN ALPHA CHAIN, SULFATE ION
Authors:Vega, M.C., Serrano, L.
Deposit date:2000-08-15
Release date:2002-05-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design
Nat.Struct.Biol., 9, 2002
1E6H
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A-SPECTRIN SH3 DOMAIN A11V, M25I, V44I, V58L MUTANTS
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Vega, M.C., Serrano, L.
Deposit date:2000-08-17
Release date:2002-05-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design
Nat.Struct.Biol., 9, 2002
1E7O
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A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V44I, V58L MUTATIONS
Descriptor:SPECTRIN ALPHA CHAIN, GLYCEROL
Authors:Vega, M.C., Serrano, L.
Deposit date:2000-08-31
Release date:2003-05-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Thermodynamic and Kinetic Analysis of the Folding Pathway of an SH3 Domain Entropically Stabilised by a Redesigned Hydrophobic Core
J.Mol.Biol., 328, 2003
1H1C
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HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (HISC) FROM THERMOTOGA MARITIMA
Descriptor:HISTIDINOL-PHOSPHATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Vega, M.C., Fernandez, F.J., Wilmanns, M.
Deposit date:2002-07-08
Release date:2004-03-19
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
J.Biol.Chem., 279, 2004
1H8K
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A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Vega, M.C., Serrano, L.
Deposit date:2001-02-09
Release date:2002-05-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design
Nat.Struct.Biol., 9, 2002
1UU0
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HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (HISC) FROM THERMOTOGA MARITIMA (APO-FORM)
Descriptor:HISTIDINOL-PHOSPHATE AMINOTRANSFERASE, PHOSPHATE ION
Authors:Vega, M.C., Fernandez, F.J., Lehmann, F., Wilmanns, M.
Deposit date:2003-12-12
Release date:2004-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
J.Biol.Chem., 279, 2004
1UU1
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COMPLEX OF HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (HISC) FROM THERMOTOGA MARITIMA (APO-FORM)
Descriptor:HISTIDINOL-PHOSPHATE AMINOTRANSFERASE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, PHOSPHORIC ACID MONO-[2-AMINO-3-(3H-IMIDAZOL-4-YL)-PROPYL]ESTER
Authors:Vega, M.C., Fernandez, F.J., Lehman, F., Wilmanns, M.
Deposit date:2003-12-12
Release date:2004-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
J.Biol.Chem., 279, 2004
1UU2
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HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (HISC) FROM THERMOTOGA MARITIMA (APO-FORM)
Descriptor:HISTIDINOL-PHOSPHATE AMINOTRANSFERASE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 1,2-ETHANEDIOL
Authors:Vega, M.C., Fernandez, F.J., Lehmann, F., Wilmanns, M.
Deposit date:2003-12-13
Release date:2004-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
J.Biol.Chem., 279, 2004
1UUE
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A-SPECTRIN SH3 DOMAIN (V44T, D48G MUTANT)
Descriptor:SPECTRIN ALPHA CHAIN
Authors:Vega, M.C., Fernandez, A., Wilmanns, M., Serrano, L.
Deposit date:2003-12-18
Release date:2004-02-19
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Solvation in Protein Folding Analysis: Combination of Theoretical and Experimental Approaches
Proc.Natl.Acad.Sci.USA, 101, 2004
1WAA
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IG27 PROTEIN DOMAIN
Descriptor:TITIN, ZINC ION
Authors:Vega, M.C., Valencia, L., Zou, P., Wilmanns, M.
Deposit date:2004-10-25
Release date:2006-07-05
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanical Network in Titin Immunoglobulin from Force Distribution Analysis.
Plos Comput.Biol., 5, 2009
2WYL
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APO STRUCTURE OF A METALLO-B-LACTAMASE
Descriptor:L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG, GLYCEROL, FORMYL GROUP
Authors:Garces, F., Fernandez, F.J., Penya-Soler, E., Aguilar, J., Baldoma, L., Coll, M., Badia, J., Vega, M.C.
Deposit date:2009-11-16
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Molecular Architecture of the Mn(2+)Dependent Lactonase Ulag Reveals an Rnase-Like Metallo-Beta-Lactamase Fold and a Novel Quaternary Structure.
J.Mol.Biol., 398, 2010
2WYM
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STRUCTURE OF A METALLO-B-LACTAMASE
Descriptor:L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG, MANGANESE (II) ION, GLYCEROL, ...
Authors:Garces, F., Fernandez, F.J., Penya-Soler, E., Aguilar, J., Baldoma, L., Coll, M., Badia, J., Vega, M.C.
Deposit date:2009-11-16
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Architecture of the Mn(2+)Dependent Lactonase Ulag Reveals an Rnase-Like Metallo-Beta-Lactamase Fold and a Novel Quaternary Structure.
J.Mol.Biol., 398, 2010
5NQ6
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CRYSTAL STRUCTURE OF THE INHIBITED FORM OF THE REDOX-SENSITIVE SUFE-LIKE SULFUR ACCEPTOR CSDE FROM ESCHERICHIA COLI AT 2.40 ANGSTROM RESOLUTION
Descriptor:Sulfur acceptor protein CsdE, GLYCEROL, SULFATE ION
Authors:Penya-Soler, E., Aranda, J., Lopez-Estepa, M., Gomez, S., Garces, F., Coll, M., Fernandez, F.J., Vega, M.C.
Deposit date:2017-04-19
Release date:2018-03-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights into the inhibited form of the redox-sensitive SufE-like sulfur acceptor CsdE.
PLoS ONE, 12, 2017
5O5X
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CRYSTAL STRUCTURE OF THERMOCOCCUS LITORALIS ADP-DEPENDENT GLUCOKINASE (GK)
Descriptor:ADP-dependent glucokinase,ADP-dependent glucokinase,ADP-dependent glucokinase, SULFATE ION, GLYCEROL
Authors:Herrera-Morande, A., Castro-Fernandez, V., Merino, F., Ramirez-Sarmiento, C.A., Fernandez, F.J., Guixe, V., Vega, M.C.
Deposit date:2017-06-02
Release date:2018-10-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Protein topology determines substrate-binding mechanism in homologous enzymes.
Biochim Biophys Acta Gen Subj, 1862, 2018
5O5Y
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CRYSTAL STRUCTURE OF THERMOCOCCUS LITORALIS ADP-DEPENDENT GLUCOKINASE (GK)
Descriptor:ADP-dependent glucokinase,ADP-dependent glucokinase,ADP-dependent glucokinase, GLYCEROL, TRIETHYLENE GLYCOL, ...
Authors:Herrera-Morande, A., Castro-Fernandez, V., Merino, F., Ramirez-Sarmiento, C.A., Fernandez, F.J., Guixe, V., Vega, M.C.
Deposit date:2017-06-02
Release date:2018-10-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.915 Å)
Cite:Protein topology determines substrate-binding mechanism in homologous enzymes.
Biochim Biophys Acta Gen Subj, 1862, 2018
5O5Z
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CRYSTAL STRUCTURE OF THERMOCOCCUS LITORALIS ADP-DEPENDENT GLUCOKINASE (GK)
Descriptor:ADP-dependent glucokinase,ADP-dependent glucokinase,ADP-dependent glucokinase, GLYCEROL, SULFATE ION, ...
Authors:Herrera-Morande, A., Castro-Fernandez, V., Merino, F., Ramirez-Sarmiento, C.A., Fernandez, F.J., Guixe, V., Vega, M.C.
Deposit date:2017-06-02
Release date:2018-10-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.441 Å)
Cite:Protein topology determines substrate-binding mechanism in homologous enzymes.
Biochim Biophys Acta Gen Subj, 1862, 2018
6FZH
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CRYSTAL STRUCTURE OF A STREPTOCOCCAL DEHYDROGENASE AT 1.5 ANGSTROEM RESOLUTION
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ...
Authors:Gomez, S., Querol-Garcia, J., Sanchez-Barron, G., Subias, M., Gonzalez-Alsina, A., Melchor-Tafur, C., Franco-Hidalgo, V., Alberti, S., Rodriguez de Cordoba, S., Fernandez, F.J., Vega, M.C.
Deposit date:2018-03-14
Release date:2019-03-27
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding.
Front Microbiol, 10, 2019
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