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3J5L
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STRUCTURE OF THE E. COLI 50S SUBUNIT WITH ERMBL NASCENT CHAIN
Descriptor:50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, ...
Authors:Arenz, S., Ramu, H., Gupta, P., Berninghausen, O., Beckmann, R., Vazquez-Laslop, N., Mankin, A.S., Wilson, D.N.
Deposit date:2013-10-23
Release date:2014-03-26
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.
Nat Commun, 5, 2014
3J7Z
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STRUCTURE OF THE E. COLI 50S SUBUNIT WITH ERMCL NASCENT CHAIN
Descriptor:50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, ...
Authors:Arenz, S., Meydan, S., Starosta, A.L., Berninghausen, O., Beckmann, R., Vazquez-Laslop, N., Wilson, D.N.
Deposit date:2014-08-27
Release date:2014-10-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation.
Mol.Cell, 56, 2014
4W2I
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NEGAMYCIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T.A., Vazquez-Laslop, N., Mankin, A.S.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA.
Mol.Cell, 56, 2014
5WIS
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH METHYMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION
Descriptor:23S ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S.
Deposit date:2017-07-20
Release date:2018-02-14
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
5WIT
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PIKROMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S.
Deposit date:2017-07-20
Release date:2018-02-14
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
3D6Y
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CRYSTAL STRUCTURE OF R275E MUTANT OF BMRR BOUND TO DNA AND BERBERINE
Descriptor:BMR promoter DNA, Multidrug-efflux transporter 1 regulator, BERBERINE, ...
Authors:Newberry, K.J., Brennan, R.G.
Deposit date:2008-05-20
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion
J.Biol.Chem., 283, 2008
3D6Z
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CRYSTAL STRUCTURE OF R275E MUTANT OF BMRR BOUND TO DNA AND RHODAMINE
Descriptor:BMR promoter DNA, Multidrug-efflux transporter 1 regulator, GLYCEROL, ...
Authors:Newberry, K.J., Brennan, R.G.
Deposit date:2008-05-20
Release date:2008-08-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion
J.Biol.Chem., 283, 2008
3D70
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CRYSTAL STRUCTURE OF E253A MUTANT OF BMRR BOUND TO 22-BP OLIGONUCLEOTIDE
Descriptor:BMR promoter DNA, Multidrug-efflux transporter 1 regulator, IMIDAZOLE, ...
Authors:Newberry, K.J., Brennan, R.G.
Deposit date:2008-05-20
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion
J.Biol.Chem., 283, 2008
3D71
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CRYSTAL STRUCTURE OF E253Q BMRR BOUND TO 22 BASE PAIR PROMOTER SITE
Descriptor:BMR promoter DNA, Multidrug-efflux transporter 1 regulator, ZINC ION, ...
Authors:Newberry, K.J., Huffman, J.L., Brennan, R.G.
Deposit date:2008-05-20
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion
J.Biol.Chem., 283, 2008
5O2R
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CRYO-EM STRUCTURE OF THE PROLINE-RICH ANTIMICROBIAL PEPTIDE API137 BOUND TO THE TERMINATING RIBOSOME
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Graf, M., Berninghausen, O., Beckmann, R., Wilson, D.N.
Deposit date:2017-05-22
Release date:2017-07-26
Last modified:2017-09-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.
Nat. Struct. Mol. Biol., 24, 2017
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