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1INV
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A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES
Descriptor:INFLUENZA VIRUS B/LEE/40 NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:White, C.L., Janakiraman, M.N., Laver, W.G., Philippon, C., Vasella, A., Air, G.M., Luo, M.
Deposit date:1994-09-26
Release date:1995-02-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
J.Mol.Biol., 245, 1995
1INW
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A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES
Descriptor:INFLUENZA A SUBTYPE N2 NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:White, C.L., Janakiraman, M.N., Laver, W.G., Philippon, C., Vasella, A., Air, G.M., Luo, M.
Deposit date:1994-09-26
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
J.Mol.Biol., 245, 1995
1INX
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A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES
Descriptor:INFLUENZA A SUBTYPE N2 NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:White, C.L., Janakiraman, M.N., Laver, W.G., Philippon, C., Vasella, A., Air, G.M., Luo, M.
Deposit date:1994-09-26
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
J.Mol.Biol., 245, 1995
1INY
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A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:White, C.L., Janakiraman, M.N., Laver, W.G., Philippon, C., Vasella, A., Air, G.M., Luo, M.
Deposit date:1994-09-26
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
J.Mol.Biol., 245, 1995
2CES
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH GLUCOIMIDAZOLE
Descriptor:BETA-GLUCOSIDASE A, ACETATE ION, GLUCOIMIDAZOLE, ...
Authors:Gloster, T.M., Roberts, S., Vasella, A., Davies, G.J.
Deposit date:2006-02-10
Release date:2006-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors.
Biochemistry, 45, 2006
2CET
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH PHENETHYL- SUBSTITUTED GLUCOIMIDAZOLE
Descriptor:BETA-GLUCOSIDASE A, ACETATE ION, (5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, ...
Authors:Gloster, T.M., Roberts, S., Vasella, A., Davies, G.J.
Deposit date:2006-02-10
Release date:2006-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors.
Biochemistry, 45, 2006
8A3H
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CELLOBIOSE-DERIVED IMIDAZOLE COMPLEX OF THE ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHAERENS AT 0.97 A RESOLUTION
Descriptor:PROTEIN (ENDOGLUCANASE), SULFATE ION, ACETATE ION, ...
Authors:Varrot, A., Schulein, M., Pipelier, M., Vasella, A., Davies, G.J.
Deposit date:1999-01-20
Release date:2000-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Lateral Protonation of a Glycosidase Inhibitor. Structure of the Bacillus agaradhaerens Cel5A in Complex with a Cellobiose-Derived Imidazole at 0.97 A Resolution
J.Am.Chem.Soc., 121, 1999
1JZ6
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E. COLI (LACZ) BETA-GALACTOSIDASE IN COMPLEX WITH GALACTO-TETRAZOLE
Descriptor:Beta-Galactosidase, (5R, 6S, ...
Authors:Juers, D.H., Heightman, T.D., Vasella, A., Matthews, B.W.
Deposit date:2001-09-13
Release date:2001-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
1LQ2
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CRYSTAL STRUCTURE OF BARLEY BETA-D-GLUCAN GLUCOHYDROLASE ISOENZYME EXO1 IN COMPLEX WITH GLUCO-PHENYLIMIDAZOLE
Descriptor:Beta-D-glucan glucohydrolase isoenzyme Exo1, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Hrmova, M., De Gori, R., Smith, B.J., Vasella, A., Varghese, J.N., Fincher, G.B.
Deposit date:2002-05-09
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Three-dimensional Structure of the Barley {beta}-D-Glucan Glucohydrolase in Complex with a Transition State Mimic.
J.Biol.Chem., 279, 2004
1NAA
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CELLOBIOSE DEHYDROGENASE FLAVOPROTEIN FRAGMENT IN COMPLEX WITH CELLOBIONOLACTAM
Descriptor:Cellobiose dehydrogenase, N-ACETYL-D-GLUCOSAMINE, 6-HYDROXY-FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Hallberg, B.M., Henriksson, G., Pettersson, G., Vasella, A., Divne, C.
Deposit date:2002-11-27
Release date:2003-01-14
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of the reductive half-reaction in cellobiose dehydrogenase
J.BIOL.CHEM., 278, 2003
1UR8
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INTERACTIONS OF A FAMILY 18 CHITINASE WITH THE DESIGNED INHIBITOR HM508, AND ITS DEGRADATION PRODUCT, CHITOBIONO-DELTA-LACTONE
Descriptor:CHITINASE B, GLYCEROL, SULFATE ION, ...
Authors:Vaaje-Kolstad, G., Vasella, A., Peter, M.G., Netter, C., Houston, D.R., Westereng, B., Synstad, B., Eijsink, V.G.H., Van Aalten, D.M.F.
Deposit date:2003-10-27
Release date:2004-04-27
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Interactions of a Family 18 Chitinase with the Designed Inhibitor Hm508 and its Degradation Product, Chitobiono-Delta-Lactone.
J.Biol.Chem., 279, 2004
1UR9
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INTERACTIONS OF A FAMILY 18 CHITINASE WITH THE DESIGNED INHIBITOR HM508, AND ITS DEGRADATION PRODUCT, CHITOBIONO-DELTA-LACTONE
Descriptor:CHITINASE B, GLYCEROL, SULFATE ION, ...
Authors:Vaaje-Kolstad, G., Vasella, A., Peter, M.G., Netter, C., Houston, D.R., Westereng, B., Synstad, B., Eijsink, V.G.H., Van Aalten, D.M.F.
Deposit date:2003-10-27
Release date:2004-04-27
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interactions of a Family 18 Chitinase with the Designed Inhibitor Hm508 and its Degradation Product, Chitobiono-Delta-Lactone.
J.Biol.Chem., 279, 2004
1UWQ
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STRUCTURE OF BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS
Descriptor:BETA-GALACTOSIDASE, ACETATE ION
Authors:Gloster, T.M., Roberts, S., Ducros, V.M.-A., Perugino, G., Rossi, M., Hoos, R., Moracci, M., Vasella, A., Davies, G.J.
Deposit date:2004-02-11
Release date:2004-05-20
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors.
Biochemistry, 43, 2004
1UWR
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STRUCTURE OF BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH 2-DEOXY-2-FLUORO-GALACTOSE
Descriptor:BETA-GALACTOSIDASE, 2-DEOXY-2-FLUORO-ALPHA-D-GALACTOPYRANOSE, ACETATE ION
Authors:Gloster, T.M., Roberts, S., Ducros, V.M.-A., Perugino, G., Rossi, M., Hoos, R., Moracci, M., Vasella, A., Davies, G.J.
Deposit date:2004-02-11
Release date:2004-05-20
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural Studies of the Beta-Glycosidase from Sulfolobus Solfataricus in Complex with Covalently and Noncovalently Bound Inhibitors.
Biochemistry, 43, 2004
1UWS
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STRUCTURE OF BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH 2-DEOXY-2-FLUORO-GLUCOSE
Descriptor:BETA-GALACTOSIDASE, 2-deoxy-2-fluoro-alpha-D-glucopyranose, ACETATE ION
Authors:Gloster, T.M., Roberts, S., Ducros, V.M.-A., Perugino, G., Rossi, M., Hoos, R., Moracci, M., Vasella, A., Davies, G.J.
Deposit date:2004-02-11
Release date:2004-05-20
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors.
Biochemistry, 43, 2004
1UWT
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STRUCTURE OF BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH D-GALACTOHYDROXIMO-1,5-LACTAM
Descriptor:BETA-GALACTOSIDASE, (2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE, ACETATE ION
Authors:Gloster, T.M., Roberts, S., Ducros, V.M.-A., Perugino, G., Rossi, M., Hoos, R., Moracci, M., Vasella, A., Davies, G.J.
Deposit date:2004-02-11
Release date:2004-05-20
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors.
Biochemistry, 43, 2004
1UWU
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STRUCTURE OF BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH D-GLUCOHYDROXIMO-1,5-LACTAM
Descriptor:BETA-GALACTOSIDASE, (2S,3S,4R,5R)-6-(HYDROXYAMINO)-2-(HYDROXYMETHYL)-2,3,4,5-TETRAHYDROPYRIDINE-3,4,5-TRIOL, ACETATE ION
Authors:Gloster, T.M., Roberts, S., Ducros, V.M.-A., Perugino, G., Rossi, M., Hoos, R., Moracci, M., Vasella, A., Davies, G.J.
Deposit date:2004-02-11
Release date:2004-05-20
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors.
Biochemistry, 43, 2004
1X38
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CRYSTAL STRUCTURE OF BARLEY BETA-D-GLUCAN GLUCOHYDROLASE ISOENZYME EXO1 IN COMPLEX WITH GLUCO-PHENYLIMIDAZOLE
Descriptor:beta-D-glucan exohydrolase isoenzyme ExoI, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Hrmova, M., Streltsov, V.A., Smith, B.J., Vasella, A., Varghese, J.N., Fincher, G.B.
Deposit date:2005-05-02
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley.
Biochemistry, 44, 2005
1X39
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CRYSTAL STRUCTURE OF BARLEY BETA-D-GLUCAN GLUCOHYDROLASE ISOENZYME EXO1 IN COMPLEX WITH GLUCO-PHENYLIMIDAZOLE
Descriptor:beta-D-glucan exohydrolase isoenzyme ExoI, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Hrmova, M., Streltsov, V.A., Smith, B.J., Vasella, A., Varghese, J.N., Fincher, G.B.
Deposit date:2005-05-02
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley.
Biochemistry, 44, 2005
1Z3W
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STRUCTURE OF PHANEROCHAETE CHRYSOSPORIUM CELLOBIOHYDROLASE CEL7D (CBH58) IN COMPLEX WITH CELLOBIOIMIDAZOLE
Descriptor:cellulase, N-ACETYL-D-GLUCOSAMINE, 5-HYDROXYMETHYL-5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDIN-6YL-7,8-DIOL-GLUCOPYRANOSIDE
Authors:Ubhayasekera, W., Vasella, A., Stahlberg, J., Mowbray, S.L.
Deposit date:2005-03-14
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of Phanerochaete chrysosporium Cel7D in complex with product and inhibitors
Febs J., 272, 2005
2AXR
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CRYSTAL STRUCTURE OF GLUCOOLIGOSACCHARIDE OXIDASE FROM ACREMONIUM STRICTUM: A NOVEL FLAVINYLATION OF 6-S-CYSTEINYL, 8ALPHA-N1-HISTIDYL FAD
Descriptor:glucooligosaccharide oxidase, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Huang, C.-H., Lai, W.-L., Vasella, A., Tsai, Y.-C., Liaw, S.-H.
Deposit date:2005-09-05
Release date:2005-09-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal Structure of Glucooligosaccharide Oxidase from Acremonium strictum: A NOVEL FLAVINYLATION OF 6-S-CYSTEINYL, 8{alpha}-N1-HISTIDYL FAD
J.Biol.Chem., 280, 2005
2CEQ
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BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH GLUCOIMIDAZOLE
Descriptor:BETA-GALACTOSIDASE, ACETATE ION, GLUCOIMIDAZOLE
Authors:Gloster, T.M., Moracci, M., Vasella, A., Davies, G.J.
Deposit date:2006-02-10
Release date:2006-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors.
Biochemistry, 45, 2006
2CER
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BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH PHENETHYL-SUBSTITUTED GLUCOIMIDAZOLE
Descriptor:BETA-GLUCOSIDASE A, (5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, ACETATE ION
Authors:Gloster, T.M., Roberts, S., Moracci, M., Vasella, A., Davies, G.J.
Deposit date:2006-02-10
Release date:2006-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors.
Biochemistry, 45, 2006
2J78
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH GLUCO- HYDROXIMOLACTAM
Descriptor:BETA-GLUCOSIDASE A, CALCIUM ION, ACETATE ION, ...
Authors:Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
Deposit date:2006-10-06
Release date:2006-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2J79
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH GALACTO- HYDROXIMOLACTAM
Descriptor:BETA-GLUCOSIDASE A, (2E,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)-2-PIPERIDINONE, ACETATE ION, ...
Authors:Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
Deposit date:2006-10-06
Release date:2006-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007