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1NNC
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INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN) COMPLEXED WITH 4-GUANIDINO-NEU5AC2EN INHIBITOR
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1995-03-15
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein Sci., 4, 1995
7NN9
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NATIVE INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN)
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1995-03-15
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein Sci., 4, 1995
1EX1
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BETA-D-GLUCAN EXOHYDROLASE FROM BARLEY
Descriptor:PROTEIN (BETA-D-GLUCAN EXOHYDROLASE ISOENZYME EXO1), N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Varghese, J.N., Hrmova, M., Fincher, G.B.
Deposit date:1998-11-10
Release date:1999-11-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase.
Structure Fold.Des., 7, 1999
1GHR
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THE THREE-DIMENSIONAL STRUCTURES OF TWO PLANT BETA-GLUCAN ENDOHYDROLASES WITH DISTINCT SUBSTRATE SPECIFICITIES
Descriptor:1,3-1,4-BETA-GLUCANASE
Authors:Varghese, J.N., Garrett, T.P.J.
Deposit date:1993-10-11
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities.
Proc.Natl.Acad.Sci.USA, 91, 1994
2BAT
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THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR
Descriptor:NEURAMINIDASE N2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1992-08-10
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.
Proteins, 14, 1992
2QWA
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THE X-RAY STRUCTURE OF A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWB
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THE X-RAY STRUCTURE OF A COMPLEX OF SIALIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWC
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THE X-RAY STRUCTURE OF A COMPLEX OF NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWD
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THE X-RAY STRUCTURE OF A COMPLEX OF 4-AMINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWE
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THE X-RAY STRUCTURE OF A COMPLEX OF 4-GUANIDINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWF
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THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWG
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THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWH
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THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWI
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THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWJ
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THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWK
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THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
1MWE
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THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1997-08-27
Release date:1998-03-04
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.
Proc.Natl.Acad.Sci.USA, 94, 1997
1N26
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CRYSTAL STRUCTURE OF THE EXTRA-CELLULAR DOMAINS OF HUMAN INTERLEUKIN-6 RECEPTOR ALPHA CHAIN
Descriptor:IL-6 Receptor alpha chain, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N., Moritz, R.L., Lou, M.-Z., van Donkelaar, A., Ji, H., Ivancic, N., Branson, K.M., Hall, N.E., Simpson, R.J.
Deposit date:2002-10-22
Release date:2002-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain.
Proc.Natl.Acad.Sci.USA, 99, 2002
1NN2
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THREE-DIMENSIONAL STRUCTURE OF THE NEURAMINIDASE OF INFLUENZA VIRUS A(SLASH)TOKYO(SLASH)3(SLASH)67 AT 2.2 ANGSTROMS RESOLUTION
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1991-03-28
Release date:1992-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution.
J.Mol.Biol., 221, 1991
1GHS
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THE THREE-DIMENSIONAL STRUCTURES OF TWO PLANT BETA-GLUCAN ENDOHYDROLASES WITH DISTINCT SUBSTRATE SPECIFICITIES
Descriptor:1,3-BETA-GLUCANASE
Authors:Garrett, T.P.J., Varghese, J.N.
Deposit date:1993-10-12
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities.
Proc.Natl.Acad.Sci.USA, 91, 1994
1NCA
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REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE-NC41 FAB COMPLEX
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
J.Mol.Biol., 227, 1992
1NCB
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CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
J.Mol.Biol., 227, 1992
1NCC
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CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
J.Mol.Biol., 227, 1992
1NCD
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REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE-NC41 FAB COMPLEX
Descriptor:INFLUENZA A SUBTYPE N9 NEURAMINIDASE, IGG2A-KAPPA NC41 FAB (LIGHT CHAIN), IGG2A-KAPPA NC41 FAB (HEAVY CHAIN), ...
Authors:Tulip, W.R., Varghese, J.N., Colman, P.M.
Deposit date:1992-01-21
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
J.Mol.Biol., 227, 1992
1L7F
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CRYSTAL STRUCTURE OF INFLUENZA VIRUS NEURAMINIDASE IN COMPLEX WITH BCX-1812
Descriptor:neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Smith, B.J., McKimm-Breshkin, J.L., McDonald, M., Fernley, R.T., Varghese, J.N., Colman, P.M.
Deposit date:2002-03-15
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002