6X7D
 
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7TV0
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7TUQ
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6X7B
 | | BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P | | Descriptor: | 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4 | | Authors: | Vann, K.R, Kutateladze, T.G. | | Deposit date: | 2020-05-29 | | Release date: | 2020-08-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.951 Å) | | Cite: | Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.
Sci Rep, 10, 2020
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6X7C
 | | BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212 | | Descriptor: | 7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4 | | Authors: | Vann, K.R, Kutateladze, T.G. | | Deposit date: | 2020-05-29 | | Release date: | 2020-08-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.
Sci Rep, 10, 2020
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6MIM
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6MIL
 | | Crystal structure of AF9 YEATS domain in complex with histone H3K9bu | | Descriptor: | DI(HYDROXYETHYL)ETHER, Histone H3K9bu, MALONATE ION, ... | | Authors: | Vann, K.R, Klein, B.J, Kutateladze, T.G. | | Deposit date: | 2018-09-19 | | Release date: | 2018-11-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
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6WXK
 | | PHF23 PHD Domain Apo | | Descriptor: | PHD finger protein 23, ZINC ION | | Authors: | Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. | | Deposit date: | 2020-05-11 | | Release date: | 2020-07-15 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nat Commun, 11, 2020
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6WW8
 | | BRD4 Bromodomain 1 in complex with triple CDK4/6-PI3K-BET inhibitor | | Descriptor: | 7-cyclopentyl-N,N-dimethyl-2-({4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Bromodomain-containing protein 4 | | Authors: | Vann, K.R, Kutateladze, T.G. | | Deposit date: | 2020-05-08 | | Release date: | 2020-08-26 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.302 Å) | | Cite: | A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity.
Cell Discov, 6, 2020
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6O5W
 | | Crystal structure of MORC3 CW domain fused with viral influenza A NS1 peptide | | Descriptor: | NS1-linked peptide,MORC family CW-type zinc finger protein 3, ZINC ION | | Authors: | Ahn, J, Zhang, Y, Vann, K.R, Kutateleadze, T. | | Deposit date: | 2019-03-04 | | Release date: | 2019-05-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.412 Å) | | Cite: | MORC3 Is a Target of the Influenza A Viral Protein NS1.
Structure, 27, 2019
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5EQ4
 | | Crystal structure of the SrpA adhesin R347E mutant from Streptococcus sanguinis | | Descriptor: | ACETATE ION, CALCIUM ION, Platelet-binding glycoprotein | | Authors: | Loukachevitch, L.V, McCulloch, K.M, Vann, K.R, Wawrzak, Z, Anderson, S, Iverson, T.M. | | Deposit date: | 2015-11-12 | | Release date: | 2016-01-27 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.
J.Biol.Chem., 291, 2016
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5EQ2
 | | Crystal Structure of the SrpA Adhesin from Streptococcus sanguinis | | Descriptor: | ACETATE ION, CALCIUM ION, Platelet-binding glycoprotein | | Authors: | Loukachevitch, L.V, McCulloch, K.M, Vann, K.R, Wawrzak, Z, Anderson, S, Iverson, T.M. | | Deposit date: | 2015-11-12 | | Release date: | 2016-01-27 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.
J.Biol.Chem., 291, 2016
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5EQ3
 | | Crystal structure of the SrpA adhesin from Streptococcus sanguinis with a sialyl galactose disaccharide bound | | Descriptor: | ACETATE ION, CALCIUM ION, N-glycolyl-alpha-neuraminic acid-(2-3)-methyl beta-D-galactopyranoside, ... | | Authors: | Loukachevitch, L.V, McCulloch, K.M, Vann, K.R, Wawrzak, Z, Anderson, S, Iverson, T.M. | | Deposit date: | 2015-11-12 | | Release date: | 2016-01-27 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.
J.Biol.Chem., 291, 2016
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6MIO
 | | Crystal structure of Taf14 YEATS domain in complex with histone H3K9pr | | Descriptor: | Histone H3K9pr, Transcription initiation factor TFIID subunit 14 | | Authors: | Klein, B.J, Andrews, F.H, Vann, K.R, Kutateladze, T.G. | | Deposit date: | 2018-09-19 | | Release date: | 2018-11-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
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6MIQ
 | | Crystal structure of Taf14 YEATS domain in complex with histone H3K9bu | | Descriptor: | Histone H3K9bu, Transcription initiation factor TFIID subunit 14 | | Authors: | Klein, B.J, Andrews, F.H, Vann, K.R, Kutateladze, T.G. | | Deposit date: | 2018-09-19 | | Release date: | 2018-11-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
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6WW4
 | | Crystal structure of HERC2 ZZ domain in complex with histone H3 tail | | Descriptor: | GLYCEROL, Histone H3.1,E3 ubiquitin-protein ligase HERC2, ZINC ION | | Authors: | Liu, J, Vann, K.R, Kutateladze, T.G. | | Deposit date: | 2020-05-07 | | Release date: | 2020-08-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.252 Å) | | Cite: | Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.
Structure, 28, 2020
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6WW3
 | | Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SUMO1 linked HERC2 ZZ domain (Small ubiquitin-related modifier 1,E3 ubiquitin-protein ligase HERC2), ... | | Authors: | Liu, J, Vann, K.R, Kutateladze, T.G. | | Deposit date: | 2020-05-07 | | Release date: | 2020-08-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.096 Å) | | Cite: | Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.
Structure, 28, 2020
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6AXJ
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6MIN
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6MIP
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