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5J3Q
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CRYSTAL STRUCTURE OF S. POMBE DCP1:EDC1 MRNA DECAPPING COMPLEX
Descriptor:mRNA-decapping enzyme subunit 1, Edc1
Authors:Valkov, E., Muthukumar, S., Chang, C.T., Jonas, S., Weichenrieder, O., Izaurralde, E.
Deposit date:2016-03-31
Release date:2016-05-18
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
Nat.Struct.Mol.Biol., 23, 2016
5J3T
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CRYSTAL STRUCTURE OF S. POMBE DCP2:DCP1:EDC1 MRNA DECAPPING COMPLEX
Descriptor:mRNA-decapping enzyme subunit 1, mRNA decapping complex subunit 2, Edc1, ...
Authors:Valkov, E., Muthukumar, S., Chang, C.T., Jonas, S., Weichenrieder, O., Izaurralde, E.
Deposit date:2016-03-31
Release date:2016-05-18
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
Nat.Struct.Mol.Biol., 23, 2016
5J3Y
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CRYSTAL STRUCTURE OF S. POMBE DCP2:DCP1 MRNA DECAPPING COMPLEX
Descriptor:mRNA-decapping enzyme subunit 1, mRNA decapping complex subunit 2
Authors:Valkov, E., Muthukumar, S., Chang, C.T., Jonas, S., Weichenrieder, O., Izaurralde, E.
Deposit date:2016-03-31
Release date:2016-05-18
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (3.288 Å)
Cite:Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
Nat.Struct.Mol.Biol., 23, 2016
2Y92
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CRYSTAL STRUCTURE OF MAL ADAPTOR PROTEIN
Descriptor:TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN,, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Valkov, E., Stamp, A., Martin, J.L., Kobe, B.
Deposit date:2011-02-11
Release date:2011-09-14
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection.
Proc.Natl.Acad.Sci.USA, 108, 2011
3DLR
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CRYSTAL STRUCTURE OF THE CATALYTIC CORE DOMAIN FROM PFV INTEGRASE
Descriptor:Integrase, MAGNESIUM ION
Authors:Valkov, E., Cherepanov, P.
Deposit date:2008-06-29
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Functional and structural characterization of the integrase from the prototype foamy virus.
Nucleic Acids Res., 37, 2009
4WPX
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CHAETOMIUM THEROMOPHILUM TREX2 CID DOMAIN COMPLEX
Descriptor:Cell division control protein 31-like protein, Putative SAC3 family protein, Putative uncharacterized protein
Authors:Valkov, E., Stewart, M.
Deposit date:2014-10-21
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
6FNY
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CRYSTAL STRUCTURE OF A CHOLINE SULFATASE FROM SINORHIZOBIUM MELLILOTI
Descriptor:Choline-sulfatase, CALCIUM ION
Authors:Valkov, E., Van Loo, B., Hollfelder, F., Hyvonen, M.
Deposit date:2018-02-05
Release date:2018-02-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.
J. Mol. Biol., 430, 2018
4AF0
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CRYSTAL STRUCTURE OF CRYPTOCOCCAL INOSINE MONOPHOSPHATE DEHYDROGENASE
Descriptor:INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, MYCOPHENOLIC ACID, INOSINIC ACID, ...
Authors:Valkov, E., Stamp, A., Morrow, C.A., Kobe, B., Fraser, J.A.
Deposit date:2012-01-15
Release date:2012-10-24
Last modified:2012-11-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:De Novo GTP Biosynthesis is Critical for Virulence of the Fungal Pathogen Cryptococcus Neoformans
Plos Pathog., 8, 2012
4UG4
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CRYSTAL STRUCTURE OF A CHOLINE SULFATASE FROM SINORHIZOBIUM MELLILOTI
Descriptor:CHOLINE SULFATASE, MANGANESE (II) ION
Authors:Valkov, E., van Loo, B., Hollfelder, F., Hyvonen, M.
Deposit date:2015-03-22
Release date:2016-04-13
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium Melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester
To be Published
4UPK
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PHOSPHONATE MONOESTER HYDROLASE SPPMH FROM SILICIBACTER POMEROYI
Descriptor:PHOSPHONATE MONOESTER HYDROLASE
Authors:Valkov, E., van Loo, B., Hollfelder, F., Hyvonen, M.
Deposit date:2014-06-17
Release date:2015-07-01
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
J. Am. Chem. Soc., 2018
5C5W
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1.25 A RESOLUTION STRUCTURE OF AN RNA 20-MER
Descriptor:RNA (5'-R(P*CP*CP*UP*GP*AP*GP*UP*UP*CP*AP*AP*UP*UP*CP*UP*AP*GP*CP*G)-3')
Authors:Stewart, M., Valkov, E.
Deposit date:2015-06-22
Release date:2015-10-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:1.25 angstrom resolution structure of an RNA 20-mer that binds to the TREX2 complex.
Acta Crystallogr.,Sect.F, 71, 2015
5FU6
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NOT MODULE OF THE HUMAN CCR4-NOT COMPLEX (CRYSTALLIZATION MUTANT)
Descriptor:CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3
Authors:Raisch, T., Bhandari, D., Sabath, K., Helms, S., Valkov, E., Weichenrieder, O., Izaurralde, E.
Deposit date:2016-01-21
Release date:2016-03-23
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos
Embo J., 35, 2016
5FU7
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DROSOPHILA NANOS NBR PEPTIDE BOUND TO THE NOT MODULE OF THE HUMAN CCR4-NOT COMPLEX
Descriptor:CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3, ...
Authors:Raisch, T., Bhandari, D., Sabath, K., Helms, S., Valkov, E., Weichenrieder, O., Izaurralde, E.
Deposit date:2016-01-21
Release date:2016-03-23
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos
Embo J., 35, 2016
5T46
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CRYSTAL STRUCTURE OF THE HUMAN EIF4E-EIF4G COMPLEX
Descriptor:Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4 gamma 1, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gruener, S., Peter, D., Weber, R., Wohlbold, L., Chung, M.-Y., Weichenrieder, O., Valkov, E., Igreja, C., Izaurralde, E.
Deposit date:2016-08-29
Release date:2016-10-26
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Mol.Cell, 64, 2016
5T47
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CRYSTAL STRUCTURE OF THE D. MELANOGASTER EIF4E-EIF4G COMPLEX
Descriptor:Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4G, isoform A, ...
Authors:Gruener, S., Peter, D., Weber, R., Wohlbold, L., Chung, M.-Y., Weichenrieder, O., Valkov, E., Igreja, C., Izaurralde, E.
Deposit date:2016-08-29
Release date:2016-10-26
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Mol.Cell, 64, 2016
5T48
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CRYSTAL STRUCTURE OF THE D. MELANOGASTER EIF4E-EIF4G COMPLEX WITHOUT LATERAL CONTACT
Descriptor:Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4G, isoform A, ...
Authors:Gruener, S., Peter, D., Weber, R., Wohlbold, L., Chung, M.-Y., Weichenrieder, O., Valkov, E., Igreja, C., Izaurralde, E.
Deposit date:2016-08-29
Release date:2016-10-26
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Mol.Cell, 64, 2016
6H3Z
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CRYSTAL STRUCTURE OF A C-TERMINAL MIF4G DOMAIN IN NOT1
Descriptor:CCR4-not transcription complex subunit 1, SODIUM ION
Authors:Raisch, T., Sandmeir, F., Weichenrieder, O., Valkov, E., Izaurralde, E.
Deposit date:2018-07-19
Release date:2018-11-07
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex.
J. Struct. Biol., 204, 2018
4WP5
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CHAETOMIUM THERMOPHILUM MEX67 NTF2-LIKE DOMAIN COMPLEXED WITH MTR2
Descriptor:mRNA export protein, Mtr2
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-10-17
Release date:2015-07-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4WP6
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STRUCTURE OF THE MEX67 LRR DOMAIN FROM CHAETOMIUM THERMOPHILUM
Descriptor:mRNA export protein
Authors:Aibara, S., Valkov, E., Lamers, M., Stewart, M.
Deposit date:2014-10-17
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4WPM
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STRUCTURE OF THE CHAETOMIUM THERMOPHILUM MEX67:MTR2 COMPLEX
Descriptor:mRNA export protein, SULFATE ION
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-10-20
Release date:2015-07-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4X2H
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SAC3N PEPTIDE BOUND TO MEX67:MTR2
Descriptor:Putative mRNA export protein, Putative uncharacterized protein, SER-SER-VAL-PHE-GLY-ALA-PRO-ALA
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-26
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
4X2M
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STRUCTURE OF MTR2
Descriptor:Mtr2
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-26
Release date:2015-07-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4X2O
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SAC3N PEPTIDE BOUND TO MEX67:MTR2
Descriptor:Putative mRNA export protein, Putative uncharacterized protein, Putative SAC3 family protein
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-26
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
5NVK
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CRYSTAL STRUCTURE OF THE HUMAN 4EHP-GIGYF1 COMPLEX
Descriptor:Eukaryotic translation initiation factor 4E type 2, GRB10-interacting GYF protein 1
Authors:Peter, D., Valkov, E.
Deposit date:2017-05-04
Release date:2017-07-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.
Genes Dev., 31, 2017
5NVL
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CRYSTAL STRUCTURE OF THE HUMAN 4EHP-GIGYF2 COMPLEX
Descriptor:Eukaryotic translation initiation factor 4E type 2, GRB10-interacting GYF protein 2
Authors:Peter, D., Valkov, E.
Deposit date:2017-05-04
Release date:2017-07-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.
Genes Dev., 31, 2017
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