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6HRM
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E. COLI 70S D2D8 STAPLED RIBOSOME
Descriptor:stapled 16S-23S rRNA,stapled 16S-23S rRNA,stapled 16S-23S rRNA,stapled 16S-23S rRNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Schmied, W.H., Tnimov, Z., Uttamapinant, C., Rae, C.D., Fried, S.D., Chin, J.W.
Deposit date:2018-09-27
Release date:2018-12-19
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Controlling orthogonal ribosome subunit interactions enables evolution of new function.
Nature, 564, 2018
3UM5
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DOUBLE MUTANT (A16V+S108T) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS-T9/94) COMPLEXED WITH PYRIMETHAMINE, NADPH, AND DUMP
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Vanichtanankul, J., Kamchonwongpaisan, S., Chitnumsub, P., Yuthavong, Y.
Deposit date:2011-11-12
Release date:2012-07-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil.
Antimicrob.Agents Chemother., 56, 2012
3UM6
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DOUBLE MUTANT (A16V+S108T) PLASMODIUM FALCIPARUM DHFR-TS (T9/94) COMPLEXED WITH CYCLOGUANIL, NADPH AND DUMP
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Vanichtanankul, J., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.
Deposit date:2011-11-12
Release date:2012-07-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil.
Antimicrob.Agents Chemother., 56, 2012
3UM8
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WILD-TYPE PLASMODIUM FALCIPARUM DHFR-TS COMPLEXED WITH CYCLOGUANIL AND NADPH
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Vanichtanankul, J., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.
Deposit date:2011-11-12
Release date:2012-07-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil.
Antimicrob.Agents Chemother., 56, 2012
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