Author results

1HAR
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2.2 ANGSTROMS RESOLUTION STRUCTURE OF THE AMINO-TERMINAL HALF OF HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS)
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS)
Authors:Unge, T., Knight, S., Strandberg, B.
Deposit date:1994-10-28
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:2.2 A resolution structure of the amino-terminal half of HIV-1 reverse transcriptase (fingers and palm subdomains).
Structure, 2, 1994
1EBY
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA369
Descriptor:HIV-1 PROTEASE, N,N-[2,5-O-DIBENZYL-GLUCARYL]-DI-[1-AMINO-INDAN-2-OL]
Authors:Unge, T.
Deposit date:2000-01-25
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.294 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
Eur.J.Biochem., 270, 2003
1D4H
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA435
Descriptor:HIV-1 PROTEASE, 2,5-DIBENZYLOXY-3,4-DIHYDROXY-HEXANEDIOIC ACID BENZYLAMIDE (2-HYDROXY-INDAN-1-YL)-AMIDE
Authors:Unge, T.
Deposit date:1999-10-04
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.
Eur.J.Biochem., 270, 2003
1D4I
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA425
Descriptor:HIV-1 PROTEASE, 2,5-DIBENZYLOXY-3-HYDROXY-HEXANEDIOIC ACID BIS-[(2-HYDROXY-INDAN-1-YL)-AMIDE]
Authors:Unge, T.
Deposit date:1999-10-04
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.
Eur.J.Biochem., 270, 2003
1D4J
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR MSL370
Descriptor:HIV-1 PROTEASE, 2,5-DIBENZYLOXY-3,4-DIHYDROXY-HEXANEDIOIC ACID 2-CHLORO-6-FLUORO-BENZYLAMIDE (2-HYDROXY-INDAN-1- YL)-AMIDE
Authors:Unge, T.
Deposit date:1999-10-04
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.
Eur.J.Biochem., 270, 2003
1EBW
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA322
Descriptor:HIV-1 PROTEASE, N,N-[2,5-O-[DIBENZYL]-GLUCARYL]-DI-[ISOLEUCYL-AMIDO-METHANE]
Authors:Unge, T.
Deposit date:2000-01-25
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
Eur.J.Biochem., 270, 2003
1EBZ
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA388
Descriptor:HIV-1 PROTEASE, [5-(2-HYDROXY-INDAN-1-YLCARBAMOYL)-3,4-DIHYDROXY-2,5-[DIBENZYL-OXY]-PENTANOYL]-VALINYL-AMIDO-METHANE
Authors:Unge, T.
Deposit date:2000-01-25
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
Eur.J.Biochem., 270, 2003
1EC0
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA403
Descriptor:HIV-1 PROTEASE, N,N-[2,5-O-DI-2-FLUORO-BENZYL-GLUCARYL]-DI-[1-AMINO-INDAN-2-OL]
Authors:Unge, T.
Deposit date:2000-01-25
Release date:2002-06-26
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy
Eur.J.Biochem., 271, 2004
1EC1
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA409
Descriptor:HIV-1 PROTEASE, N,N-[2,5-O-[DI-4-THIOPHEN-3-YL-BENZYL]-GLUCARYL]-DI-[VALYL-AMIDO-METHANE]
Authors:Unge, T.
Deposit date:2000-01-25
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
Eur.J.Biochem., 270, 2003
1EC2
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA428
Descriptor:HIV-1 PROTEASE, N,N-[2,5-O-[DI-4-PYRIDIN-3-YL-BENZYL]-GLUCARYL]-DI-[VALYL-AMIDO-METHANE]
Authors:Unge, T.
Deposit date:2000-01-25
Release date:2002-06-26
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
Eur.J.Biochem., 270, 2003
1EC3
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HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR MSA367
Descriptor:HIV-1 PROTEASE, N,N-[2,5-O-DIBENZYL-GLUCARYL]-DI-[VALINYL-AMINOMETHANYL-PYRIDINE]
Authors:Unge, T.
Deposit date:2000-01-25
Release date:2002-06-26
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors
Eur.J.Biochem., 270, 2003
2BQV
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HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455
Descriptor:HIV-1 PROTEASE, 6-AMINO HEXANOIC ACID
Authors:Unge, T., Ekegren, J.K., Schenk, H.V., Zreik Safa, M., Wallberg, H., Samuelsson, B., Hallberg, A.
Deposit date:2005-04-28
Release date:2005-12-14
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A New Class of HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold.
J.Med.Chem., 48, 2005
3ZHX
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZHY
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A DI- SUBSTITUTED FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid, ...
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZHZ
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]carbonyl-amino]propyl]phosphonic acid
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZI0
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-{hydroxy[2-(1H-1,2,4-triazol-1-ylmethyl)benzoyl]amino}propyl]phosphonic acid, MANGANESE (II) ION
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
2Y1C
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH MANGANESE.
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION
Authors:Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
J.Med.Chem, 54, 2011
2Y1D
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4- DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE.
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, (1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC ACID, MANGANESE (II) ION
Authors:Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
J.Med.Chem, 54, 2011
2Y1E
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH MANGANESE.
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, SULFATE ION
Authors:Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
J.Med.Chem, 54, 2011
2Y1F
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4- DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, MANGANESE AND NADPH.
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, (1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
J.Med.Chem, 54, 2011
2Y1G
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4- DICHLOROPHENYL-SUBSTITUTED FR900098 ANALOGUE AND MANGANESE.
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID, MANGANESE (II) ION, ...
Authors:Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
J.Med.Chem, 54, 2011
1WBK
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HIV-1 PROTEASE IN COMPLEX WITH ASYMMETRIC INHIBITOR, BEA568
Descriptor:POL PROTEIN (FRAGMENT), N,N-[2,5-O-DIBENZYL-GLUCARYL]-DI-[1-AMINO-INDAN-2-OL]
Authors:Lindberg, J., Unge, T.
Deposit date:2004-11-02
Release date:2004-11-04
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:HIV-1 Protease in Complex with Asymmetric Inhibitor, Bea568
To be Published
1WBM
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HIV-1 PROTEASE IN COMPLEX WITH SYMMETRIC INHIBITOR, BEA450
Descriptor:POL PROTEIN (FRAGMENT), (2R,3R,4R,5R)-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-2,5-BIS(2-PHENYLETHYL)HEXANEDIAMIDE
Authors:Lindberg, J., Unge, T.
Deposit date:2004-11-02
Release date:2004-11-04
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:HIV-1 Protease in Complex with Symmetric Inhibitor, Bea450
To be Published
2X1L
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CRYSTAL STRUCTURE OF MYCOBACTERIUM SMEGMATIS METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH METHIONINE AND ADENOSINE
Descriptor:METHIONYL-TRNA SYNTHETASE, METHIONINE, ADENOSINE, ...
Authors:Ingvarsson, H., Jones, T.A., Unge, T.
Deposit date:2009-12-31
Release date:2010-07-28
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Flexibility and Communication within the Structure of the Mycobacterium Smegmatis Methionyl-tRNA Synthetase.
FEBS J., 277, 2010
2X1M
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CRYSTAL STRUCTURE OF MYCOBACTERIUM SMEGMATIS METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH METHIONINE
Descriptor:METHIONYL-TRNA SYNTHETASE, METHIONINE, DIHYDROGENPHOSPHATE ION, ...
Authors:Ingvarsson, H., Jones, T.A., Unge, T.
Deposit date:2009-12-31
Release date:2010-07-28
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Flexibility and Communication within the Structure of the Mycobacterium Smegmatis Methionyl-tRNA Synthetase.
FEBS J., 277, 2010