Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5NAD
DownloadVisualize
BU of 5nad by Molmil
TTK kinase domain in complex with BAY 1217389
Descriptor: BAY 1217389, Dual specificity protein kinase TTK
Authors:Uitdehaag, J.C.M, Willemsen-Seegers, N, Sterrenburg, J.G, de Man, J, Buijsman, R.C, Zaman, G.J.R.
Deposit date:2017-02-27
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
1FP9
DownloadVisualize
BU of 1fp9 by Molmil
STRUCTURE OF AMYLOMALTASE FROM THERMUS THERMOPHILUS HB8 IN SPACE GROUP C2
Descriptor: 4-ALPHA-GLUCANOTRANSFERASE
Authors:Uitdehaag, J.C.M, Euverink, G.J, van der Veen, B.A, van der Maarel, M, Dijkstra, B.W.
Deposit date:2000-08-31
Release date:2003-09-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the amylomaltase from Thermus thermophilus HB8 in space group C2
To be Published
1FP8
DownloadVisualize
BU of 1fp8 by Molmil
STRUCTURE OF THE AMYLOMALTASE FROM THERMUS THERMOPHILUS HB8 IN SPACE GROUP P21212
Descriptor: 4-ALPHA-GLUCANOTRANSFERASE, CHLORIDE ION, MERCURY (II) ION
Authors:Uitdehaag, J.C.M, Euverink, G.J, van der Veen, B.A, van der Maarel, M, Dijkstra, B.W.
Deposit date:2000-08-31
Release date:2003-09-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and mechanism of the amylomaltase from Thermus thermophilus HB8
To be Published
1EO7
DownloadVisualize
BU of 1eo7 by Molmil
BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYLTRANSFERASE IN COMPLEX WITH MALTOHEXAOSE
Descriptor: CALCIUM ION, PROTEIN (CYCLODEXTRIN GLYCOSYLTRANSFERASE), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:Uitdehaag, J.C.M, Dijkstra, B.W.
Deposit date:2000-03-22
Release date:2000-11-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structures of maltohexaose and maltoheptaose bound at the donor sites of cyclodextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and cyclodextrin size specificity.
Biochemistry, 39, 2000
1EO5
DownloadVisualize
BU of 1eo5 by Molmil
Bacillus circulans strain 251 cyclodextrin glycosyltransferase in complex with maltoheptaose
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, PROTEIN (CYCLODEXTRIN GLYCOSYLTRANSFERASE), ...
Authors:Uitdehaag, J.C.M, Dijkstra, B.W.
Deposit date:2000-03-22
Release date:2000-11-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of maltohexaose and maltoheptaose bound at the donor sites of cyclodextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and cyclodextrin size specificity.
Biochemistry, 39, 2000
1D3C
DownloadVisualize
BU of 1d3c by Molmil
MICHAELIS COMPLEX OF BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYLTRANSFERASE WITH GAMMA-CYCLODEXTRIN
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CYCLODEXTRIN GLYCOSYLTRANSFERASE, ...
Authors:Uitdehaag, J.C.M, Kalk, K.H, van der Veen, B.A, Dijkhuizen, L, Dijkstra, B.W.
Deposit date:1999-09-29
Release date:1999-12-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The cyclization mechanism of cyclodextrin glycosyltransferase (CGTase) as revealed by a gamma-cyclodextrin-CGTase complex at 1.8-A resolution.
J.Biol.Chem., 274, 1999
1DTU
DownloadVisualize
BU of 1dtu by Molmil
BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYLTRANSFERASE: A MUTANT Y89D/S146P COMPLEXED TO AN HEXASACCHARIDE INHIBITOR
Descriptor: 1-AMINO-2,3-DIHYDROXY-5-HYDROXYMETHYL CYCLOHEX-5-ENE, CALCIUM ION, PROTEIN (CYCLODEXTRIN GLYCOSYLTRANSFERASE), ...
Authors:Uitdehaag, J.C.M, Kalk, K.H, Dijkstra, B.W.
Deposit date:2000-01-13
Release date:2000-03-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin production.
J.Mol.Biol., 296, 2000
2W8Y
DownloadVisualize
BU of 2w8y by Molmil
RU486 bound to the progesterone receptor in a destabilized agonistic conformation
Descriptor: (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one, 1,2-ETHANEDIOL, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, ...
Authors:Raaijmakers, H.C.A, Versteeg, J, Uitdehaag, J.C.M.
Deposit date:2009-01-20
Release date:2009-04-28
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.
J.Biol.Chem., 284, 2009
1NT0
DownloadVisualize
BU of 1nt0 by Molmil
Crystal structure of the CUB1-EGF-CUB2 region of MASP2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Feinberg, H, Uitdehaag, J.C.M, Davies, J.M, Wallis, R, Drickamer, K, Weis, W.I.
Deposit date:2003-01-28
Release date:2003-05-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
Embo J., 22, 2003
2DIJ
DownloadVisualize
BU of 2dij by Molmil
COMPLEX OF A Y195F MUTANT CGTASE FROM B. CIRCULANS STRAIN 251 COMPLEXED WITH A MALTONONAOSE INHIBITOR AT PH 9.8 OBTAINED AFTER SOAKING THE CRYSTAL WITH ACARBOSE AND MALTOHEXAOSE
Descriptor: 1-AMINO-2,3-DIHYDROXY-5-HYDROXYMETHYL CYCLOHEX-5-ENE, CALCIUM ION, CYCLODEXTRIN GLYCOSYLTRANSFERASE, ...
Authors:Strokopytov, B.V, Knegtel, R.M.A, Uitdehaag, J.C.M, Dijkstra, B.W.
Deposit date:1998-05-27
Release date:1998-12-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of cyclodextrin glycosyltransferase complexed with a maltononaose inhibitor at 2.6 angstrom resolution. Implications for product specificity.
Biochemistry, 35, 1996
6Q9P
DownloadVisualize
BU of 6q9p by Molmil
Crystal structure of human Arginase-1 at pH 9.0 in complex with ABH
Descriptor: 2(S)-AMINO-6-BORONOHEXANOIC ACID, Arginase-1, MANGANESE (II) ION, ...
Authors:Grobben, Y, Uitdehaag, J.C.M, Zaman, G.J.R.
Deposit date:2018-12-18
Release date:2019-12-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158.
J Struct Biol X, 4, 2020
6QAF
DownloadVisualize
BU of 6qaf by Molmil
Crystal structure of human Arginase-1 at pH 9.0 in complex with CB-1158/INCB001158
Descriptor: Arginase-1, MANGANESE (II) ION, SODIUM ION, ...
Authors:Grobben, Y, Uitdehaag, J.C.M, Tabak, W.W.A, Zaman, G.J.R.
Deposit date:2018-12-19
Release date:2019-12-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158.
J Struct Biol X, 4, 2020
6Q92
DownloadVisualize
BU of 6q92 by Molmil
Crystal structure of human Arginase-1 at pH 7.0 in complex with ABH
Descriptor: 2(S)-AMINO-6-BORONOHEXANOIC ACID, Arginase-1, MANGANESE (II) ION, ...
Authors:Grobben, Y, Uitdehaag, J.C.M, Zaman, G.J.R.
Deposit date:2018-12-17
Release date:2019-12-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158.
J Struct Biol X, 4, 2020
2CXG
DownloadVisualize
BU of 2cxg by Molmil
CYCLODEXTRIN GLYCOSYLTRANSFERASE COMPLEXED TO THE INHIBITOR ACARBOSE
Descriptor: 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, CALCIUM ION, CYCLODEXTRIN GLYCOSYLTRANSFERASE, ...
Authors:Strokopytov, B.V, Uitdehaag, J.C.M, Ruiterkamp, R, Dijkstra, B.W.
Deposit date:1998-05-08
Release date:1998-10-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose. Implications for the catalytic mechanism of glycosidases.
Biochemistry, 34, 1995
1A47
DownloadVisualize
BU of 1a47 by Molmil
CGTASE FROM THERMOANAEROBACTERIUM THERMOSULFURIGENES EM1 IN COMPLEX WITH A MALTOHEXAOSE INHIBITOR
Descriptor: 1-AMINO-2,3-DIHYDROXY-5-HYDROXYMETHYL CYCLOHEX-5-ENE, CALCIUM ION, CYCLODEXTRIN GLYCOSYLTRANSFERASE, ...
Authors:Uitdehaag, J.C.M, Kalk, K.H, Rozeboom, H.J, Dijkstra, B.W.
Deposit date:1998-02-11
Release date:1998-06-17
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Engineering of cyclodextrin product specificity and pH optima of the thermostable cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1.
J.Biol.Chem., 273, 1998
5N84
DownloadVisualize
BU of 5n84 by Molmil
TTK kinase domain in complex with Mps-BAY2b
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, Dual specificity protein kinase TTK, SODIUM ION, ...
Authors:Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R.
Deposit date:2017-02-22
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5N9S
DownloadVisualize
BU of 5n9s by Molmil
TTK kinase domain in complex with BAY 1161909
Descriptor: (2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide, Dual specificity protein kinase TTK
Authors:Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R.
Deposit date:2017-02-27
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5NA0
DownloadVisualize
BU of 5na0 by Molmil
TTK kinase domain in complex with a PEG-linked pyrimido-indolizine
Descriptor: Dual specificity protein kinase TTK, ~{N}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide
Authors:Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R.
Deposit date:2017-02-27
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5N87
DownloadVisualize
BU of 5n87 by Molmil
TTK kinase domain in complex with NTRC 0066-0
Descriptor: 2,5,8,11-TETRAOXATRIDECANE, Dual specificity protein kinase TTK, SODIUM ION, ...
Authors:Uitdehaag, J, Willemsen-Seegers, N, Sterrenburg, J.G, de Man, J, Buijsman, R.C, Zaman, G.J.R.
Deposit date:2017-02-23
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5N93
DownloadVisualize
BU of 5n93 by Molmil
TTK kinase domain in complex with TC-Mps1-12
Descriptor: 4-[[4-azanyl-6-(~{tert}-butylamino)-5-cyano-pyridin-2-yl]amino]benzamide, Dual specificity protein kinase TTK
Authors:Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R.
Deposit date:2017-02-24
Release date:2017-05-31
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5N7V
DownloadVisualize
BU of 5n7v by Molmil
TTK kinase domain in complex with MPI-0479605
Descriptor: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Dual specificity protein kinase TTK, ~{N}6-cyclohexyl-~{N}2-(2-methyl-4-morpholin-4-yl-phenyl)-7~{H}-purine-2,6-diamine
Authors:Uitdehaag, J, Willemsen-Seegers, N, Zaman, G.J.R.
Deposit date:2017-02-21
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
1CXK
DownloadVisualize
BU of 1cxk by Molmil
COMPLEX BETWEEN A MALTONONAOSE SUBSTRATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q/D229N
Descriptor: CALCIUM ION, PROTEIN (CYCLODEXTRIN-GLYCOSYLTRANSFERASE), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:Uitdehaag, J.C.M, Kalk, K.H, Dijkstra, B.W.
Deposit date:1999-02-24
Release date:1999-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family.
Nat.Struct.Biol., 6, 1999
1CXL
DownloadVisualize
BU of 1cxl by Molmil
COMPLEX BETWEEN A COVALENT INTERMEDIATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-deoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 4-deoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:Uitdehaag, J.C.M, Dijkstra, B.W.
Deposit date:1999-02-27
Release date:1999-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family.
Nat.Struct.Biol., 6, 1999
3KWB
DownloadVisualize
BU of 3kwb by Molmil
Structure of CatK covalently bound to a dioxo-triazine inhibitor
Descriptor: 3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile, Cathepsin K
Authors:Uitdehaag, J.C.M, van Zeeland, M.
Deposit date:2009-12-01
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Dioxo-triazines as a novel series of cathepsin K inhibitors
Bioorg.Med.Chem.Lett., 20, 2010
3KW9
DownloadVisualize
BU of 3kw9 by Molmil
X-ray structure of Cathepsin K covalently bound to a triazine ligand
Descriptor: 4-(cyclohexylamino)-6-piperazin-1-yl-1,3,5-triazine-2-carbonitrile, Cathepsin K, trifluoroacetic acid
Authors:Uitdehaag, J.C.M, van Zeeland, M.
Deposit date:2009-12-01
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon