Author results

1DV9
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STRUCTURAL CHANGES ACCOMPANYING PH-INDUCED DISSOCIATION OF THE B-LACTOGLOBULIN DIMER
Descriptor:BETA-LACTOGLOBULIN
Authors:Uhrinova, S., Smith, M.H., Jameson, G.B., Uhrin, D., Sawyer, L., Barlow, P.N.
Deposit date:2000-01-20
Release date:2000-02-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural changes accompanying pH-induced dissociation of the beta-lactoglobulin dimer.
Biochemistry, 39, 2000
1FZT
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SOLUTION STRUCTURE AND DYNAMICS OF AN OPEN B-SHEET, GLYCOLYTIC ENZYME-MONOMERIC 23.7 KDA PHOSPHOGLYCERATE MUTASE FROM SCHIZOSACCHAROMYCES POMBE
Descriptor:PHOSPHOGLYCERATE MUTASE
Authors:Uhrinova, S., Uhrin, D., Nairn, J., Price, N.C., Fothergill-Gilmore, L.A.
Deposit date:2000-10-04
Release date:2001-03-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of an open beta-sheet, glycolytic enzyme, monomeric 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombe.
J.Mol.Biol., 306, 2001
3OXU
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COMPLEMENT COMPONENTS FACTOR H CCP19-20 AND C3D IN COMPLEX
Descriptor:Complement C3, HF protein, GLYCEROL
Authors:Morgan, H.P., Schmidt, C.Q., Guariento, M., Gillespie, D., Herbert, A.P., Mertens, H., Blaum, B.S., Svergun, D., Johansson, C.M., Uhrin, D., Barlow, P.N., Hannan, J.P.
Deposit date:2010-09-22
Release date:2011-02-16
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for engagement by complement factor H of C3b on a self surface.
Nat.Struct.Mol.Biol., 18, 2011
1Z1M
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NMR STRUCTURE OF UNLIGANDED MDM2
Descriptor:Ubiquitin-protein ligase E3 Mdm2
Authors:Uhrinova, S., Uhrin, D., Powers, H., Watt, K., Zheleva, D., Fischer, P., McInnes, C., Barlow, P.N.
Deposit date:2005-03-04
Release date:2005-06-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding
J.Mol.Biol., 350, 2005
2KMG
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THE STRUCTURE OF THE KLCA AND ARDB PROTEINS SHOW A NOVEL FOLD AND ANTIRESTRICTION ACTIVITY AGAINST TYPE I DNA RESTRICTION SYSTEMS IN VIVO BUT NOT IN VITRO
Descriptor:KlcA
Authors:Serfiotis-Mitsa, D., Herbert, A.P., Roberts, G.A., Soares, D.C., White, J.H., Blakely, G.W., Uhrin, D., Dryden, D.T.F.
Deposit date:2009-07-28
Release date:2009-12-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro
Nucleic Acids Res., 38, 2010
2RLP
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NMR STRUCTURE OF CCP MODULES 1-2 OF COMPLEMENT FACTOR H
Descriptor:Complement factor H
Authors:Hocking, H.G., Herbert, A.P., Pangburn, M.K., Kavanagh, D., Barlow, P.N., Uhrin, D.
Deposit date:2007-07-28
Release date:2008-02-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
J.Biol.Chem., 283, 2008
2RLQ
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NMR STRUCTURE OF CCP MODULES 2-3 OF COMPLEMENT FACTOR H
Descriptor:Complement factor H
Authors:Hocking, H.G., Herbert, A.P., Pangburn, M.K., Kavanagh, D., Barlow, P.N., Uhrin, D.
Deposit date:2007-07-29
Release date:2008-02-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
J.Biol.Chem., 283, 2008
1E5G
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SOLUTION STRUCTURE OF CENTRAL CP MODULE PAIR OF A POX VIRUS COMPLEMENT INHIBITOR
Descriptor:COMPLEMENT CONTROL PROTEIN C3
Authors:Henderson, C.E., Bromek, K., Mullin, N.P., Smith, B.O., Uhrin, D., Barlow, P.N.
Deposit date:2000-07-25
Release date:2000-08-31
Last modified:2013-07-03
Method:SOLUTION NMR
Cite:Solution Structure and Dynamics of the Central Ccp Module Pair of a Poxvirus Complement Control Protein
J.Mol.Biol., 307, 2001
1GKG
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STRUCTURE DETERMINATION AND RATIONAL MUTAGENESIS REVEAL BINDING SURFACE OF IMMUNE ADHERENCE RECEPTOR, CR1 (CD35)
Descriptor:COMPLEMENT RECEPTOR TYPE 1
Authors:Smith, B.O., Mallin, R.L., Krych-Goldberg, M., Wang, X., Hauhart, R.E., Bromek, K., Uhrin, D., Atkinson, J.P., Barlow, P.N.
Deposit date:2001-08-14
Release date:2002-04-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the C3B Binding Site of Cr1 (Cd35), the Immune Adherence Receptor
Cell(Cambridge,Mass.), 108, 2002
1GKN
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STRUCTURE DETERMINATION AND RATIONAL MUTAGENESIS REVEAL BINDING SURFACE OF IMMUNE ADHERENCE RECEPTOR, CR1 (CD35)
Descriptor:COMPLEMENT RECEPTOR TYPE 1
Authors:Smith, B.O., Mallin, R.L., Krych-Goldberg, M., Wang, X., Hauhart, R.E., Bromek, K., Uhrin, D., Atkinson, J.P., Barlow, P.N.
Deposit date:2001-08-16
Release date:2002-04-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the C3B Binding Site of Cr1 (Cd35), the Immune Adherence Receptor
Cell(Cambridge,Mass.), 108, 2002
1H67
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NMR STRUCTURE OF THE CH DOMAIN OF CALPONIN
Descriptor:CALPONIN ALPHA
Authors:Bramham, J., Smith, B.O., Uhrin, D., Barlow, P.N., Winder, S.J.
Deposit date:2001-06-07
Release date:2002-02-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Calponin Ch Domain and Fitting to the 3D-Helical Reconstruction of F-Actin:Calponin.
Structure, 10, 2002
1NWV
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SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR
Descriptor:Complement decay-accelerating factor
Authors:Uhrinova, S., Lin, F., Ball, G., Bromek, K., Uhrin, D., Medof, M.E., Barlow, P.N.
Deposit date:2003-02-07
Release date:2003-04-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a functionally active fragment of decay-accelerating factor
Proc.Natl.Acad.Sci.USA, 100, 2003
1PPQ
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NMR STRUCTURE OF 16TH MODULE OF IMMUNE ADHERENCE RECEPTOR, CR1 (CD35)
Descriptor:Complement receptor type 1
Authors:O'Leary, J.M., Bromek, K., Black, G.M., Uhrinova, S., Schmitz, C., Krych, M., Atkinson, J.P., Uhrin, D., Barlow, P.N.
Deposit date:2003-06-17
Release date:2004-05-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces.
Protein Sci., 13, 2004
1QK9
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THE SOLUTION STRUCTURE OF THE DOMAIN FROM MECP2 THAT BINDS TO METHYLATED DNA
Descriptor:METHYL-CPG-BINDING PROTEIN 2
Authors:Wakefield, R.I.D., Smith, B.O., Nan, X., Free, A., Soteriou, A., Uhrin, D., Bird, A.P., Barlow, P.N.
Deposit date:1999-07-12
Release date:1999-10-08
Last modified:2018-04-18
Method:SOLUTION NMR
Cite:The Solution Structure of the Domain from Mecp2 that Binds to Methylated DNA
J.Mol.Biol., 291, 1999
1SRZ
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SOLUTION STRUCTURE OF THE SECOND COMPLEMENT CONTROL PROTEIN (CCP) MODULE OF THE GABA(B)R1A RECEPTOR, PRO-119 TRANS CONFORMER
Descriptor:Gamma-aminobutyric acid type B receptor, subunit 1
Authors:Blein, S., Uhrin, D., Smith, B.O., White, J.H., Barlow, P.N.
Deposit date:2004-03-23
Release date:2004-10-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Analysis of the Complement Control Protein (CCP) Modules of GABAB Receptor 1a: ONLY ONE OF THE TWO CCP MODULES IS COMPACTLY FOLDED
J.Biol.Chem., 279, 2004
1SS2
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SOLUTION STRUCTURE OF THE SECOND COMPLEMENT CONTROL PROTEIN (CCP) MODULE OF THE GABA(B)R1A RECEPTOR, PRO-119 CIS CONFORMER
Descriptor:Gamma-aminobutyric acid type B receptor, subunit 1
Authors:Blein, S., Uhrin, D., Smith, B.O., White, J.H., Barlow, P.N.
Deposit date:2004-03-23
Release date:2004-10-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded.
J.Biol.Chem., 279, 2004
1XWE
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NMR STRUCTURE OF C345C (NTR) DOMAIN OF C5 OF COMPLEMENT
Descriptor:Complement C5
Authors:Bramham, J., Thai, C.-T., Soares, D.C., Uhrin, D., Ogata, R.T., Barlow, P.N.
Deposit date:2004-10-30
Release date:2004-12-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Functional Insights from the Structure of the Multifunctional C345C Domain of C5 of Complement
J.Biol.Chem., 280, 2005
2A55
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SOLUTION STRUCTURE OF THE TWO N-TERMINAL CCP MODULES OF C4B-BINDING PROTEIN (C4BP) ALPHA-CHAIN.
Descriptor:C4b-binding protein
Authors:Jenkins, H.T., Mark, L., Ball, G., Lindahl, G., Uhrin, D., Blom, A.M., Barlow, P.N.
Deposit date:2005-06-30
Release date:2005-12-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Human C4b-binding Protein, Structural Basis for Interaction with Streptococcal M Protein, a Major Bacterial Virulence Factor
J.Biol.Chem., 281, 2006
2BZM
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SOLUTION STRUCTURE OF THE PRIMARY HOST RECOGNITION REGION OF COMPLEMENT FACTOR H
Descriptor:COMPLEMENT FACTOR H
Authors:Herbert, A.P., Uhrin, D., Lyon, M., Pangburn, M.K., Barlow, P.N.
Deposit date:2005-08-18
Release date:2006-03-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Disease-Associated Sequence Variations Congregate in a Polyanion Recognition Patch on Human Factor H Revealed in Three-Dimensional Structure.
J.Biol.Chem., 281, 2006
2JGW
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STRUCTURE OF CCP MODULE 7 OF COMPLEMENT FACTOR H - THE AMD AT RISK VARIENT (402H)
Descriptor:COMPLEMENT FACTOR H
Authors:Herbert, A.P., Deakin, J.A., Schmidt, C.Q., Blaum, B.S., Egan, C., Ferreira, V.P., Pangburn, M.K., Lyon, M., Uhrin, D., Barlow, P.N.
Deposit date:2007-02-16
Release date:2007-03-20
Last modified:2018-05-02
Method:SOLUTION NMR
Cite:Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
J. Biol. Chem., 282, 2007
2JGX
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STRUCTURE OF CCP MODULE 7 OF COMPLEMENT FACTOR H - THE AMD NOT AT RISK VARIENT (402Y)
Descriptor:COMPLEMENT FACTOR H
Authors:Herbert, A.P., Deakin, J.A., Schmidt, C.Q., Blaum, B.S., Egan, C., Ferreira, V.P., Pangburn, M.K., Lyon, M., Uhrin, D., Barlow, P.N.
Deposit date:2007-02-16
Release date:2007-03-20
Last modified:2018-05-02
Method:SOLUTION NMR
Cite:Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
J. Biol. Chem., 282, 2007
2KMS
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COMBINED HIGH- AND LOW-RESOLUTION TECHNIQUES REVEAL COMPACT STRUCTURE IN CENTRAL PORTION OF FACTOR H DESPITE LONG INTER-MODULAR LINKERS
Descriptor:Complement factor H
Authors:Schmidt, C.Q., Herbert, A.P., Guariento, M., Mertens, H.D.T., Soares, D.C., Uhrin, D., Rowe, A.J., Svergun, D.I., Barlow, P.N.
Deposit date:2009-08-04
Release date:2009-11-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Central Portion of Factor H (Modules 10-15) Is Compact and Contains a Structurally Deviant CCP Module
J.Mol.Biol., 395, 2010
2UWN
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT FACTOR H, SCR DOMAINS 6-8 (H402 RISK VARIANT), IN COMPLEX WITH LIGAND.
Descriptor:HUMAN COMPLEMENT FACTOR H, SUCROSE OCTASULFATE, ACETATE ION, ...
Authors:Prosser, B.E., Johnson, S., Roversi, P., Herbert, A.P., Blaum, B.S., Tyrrell, J., Jowitt, T.A., Clark, S.J., Terelli, E., Uhrin, D., Barlow, P.N., Sim, R.B., Day, A.J., Lea, S.M.
Deposit date:2007-03-22
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
J.Exp.Med., 204, 2007
2V8E
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT FACTOR H, SCR DOMAINS 6-8 (H402 RISK VARIANT), IN COMPLEX WITH LIGAND.
Descriptor:COMPLEMENT FACTOR H, SUCROSE OCTASULFATE, CHLORIDE ION, ...
Authors:Prosser, B.E., Johnson, S., Roversi, P., Herbert, A.P., Blaum, B.S., Tyrrell, J., Jowitt, T.A., Clark, S.J., Tarelli, E., Uhrin, D., Barlow, P.N., Sim, R.B., Day, A.J., Lea, S.M.
Deposit date:2007-08-07
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
J.Exp.Med., 204, 2007
1OGW
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SYNTHETIC UBIQUITIN WITH FLUORO-LEU AT 50 AND 67
Descriptor:UBIQUITIN
Authors:Alexeev, D., Ramage, R., Young, D.W., Sawyer, L.
Deposit date:2003-05-13
Release date:2003-05-30
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Synthesis, Structural and Biological Studies of Ubiquitin Mutants Containing (2S, 4S)-5-Fluoroleucine Residues Strategically Placed in the Hydrophobic Core
Chembiochem, 4, 2003
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