1HP9
 
 | | kappa-Hefutoxins: a novel Class of Potassium Channel Toxins from Scorpion venom | | Descriptor: | kappa-hefutoxin 1 | | Authors: | Srinivasan, K.N, Sivaraja, V, Huys, I, Sasaki, T, Cheng, B, Kumar, T.K.S, Sato, K, Tytgat, J, Yu, C, Brian Chia, C.S, Ranganathan, S, Bowie, J.H, Kini, R.M, Gopalakrishnakone, P. | | Deposit date: | 2000-12-12 | | Release date: | 2002-08-28 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity.
J.Biol.Chem., 277, 2002
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2XZ5
 | | MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, ... | | Authors: | Brams, M, Gay, E.A, Colon Saez, J, Guskov, A, van Elk, R, van der Schors, R.C, Peigneur, S, Tytgat, J, Strelkov, S.V, Smit, A.B, Yakel, J.L, Ulens, C. | | Deposit date: | 2010-11-23 | | Release date: | 2010-12-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structures of a Cysteine-Modified Mutant in Loop D of Acetylcholine Binding Protein
J.Biol.Chem., 286, 2011
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2XZ6
 | | MTSET-modified Y53C mutant of Aplysia AChBP | | Descriptor: | 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, SOLUBLE ACETYLCHOLINE RECEPTOR | | Authors: | Brams, M, Gay, E.A, Colon Saez, J, Guskov, A, Van Elk, R, Van Der Schors, R.C, Peigneur, S, Tytgat, J, Strelkov, S.V, Smit, A.B, Yakel, J.L, Ulens, C. | | Deposit date: | 2010-11-23 | | Release date: | 2010-12-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.137 Å) | | Cite: | Crystal Structures of a Cysteine-Modified Mutant in Loop D of Acetylcholine Binding Protein
J.Biol.Chem., 286, 2011
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2YEN
 | | Solution structure of the skeletal muscle and neuronal voltage gated sodium channel antagonist mu-conotoxin CnIIIC | | Descriptor: | Mu-conotoxin CnIIIC | | Authors: | Favreau, P, Benoit, E, Hocking, H.G, Carlier, L, D'hoedt, D, Leipold, E, Markgraf, R, Schlumberger, S, Cordova, M.A, Gaertner, H, Paolini-Bertrand, M, Hartley, O, Tytgat, J, Heinemann, S.H, Bertrand, D, Boelens, R, Stocklin, R, Molgo, J. | | Deposit date: | 2011-03-28 | | Release date: | 2012-02-08 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | A Novel Mu-Conopeptide, Cniiic, Exerts Potent and Preferential Inhibition of Na(V) 1.2/1.4 Channels and Blocks Neuronal Nicotinic Acetylcholine Receptors.
Br.J.Pharmacol., 166, 2012
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4D7T
 | | Structure of the SthK Carboxy-Terminal Region in complex with cAMP | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, STHK_CNBD_CAMP | | Authors: | Kesters, D, Brams, M, Nys, M, Wijckmans, E, Spurny, R, Voets, T, Tytgat, J, Ulens, C. | | Deposit date: | 2014-11-27 | | Release date: | 2015-02-11 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.582 Å) | | Cite: | Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels.
Plos One, 10, 2015
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4D7S
 | | Structure of the SthK Carboxy-Terminal Region in complex with cGMP | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, STHK_CNBD_CGMP | | Authors: | Kesters, D, Brams, M, Nys, M, Wijckmans, E, Spurny, R, Voets, T, Tytgat, J, Ulens, C. | | Deposit date: | 2014-11-27 | | Release date: | 2015-02-11 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels.
Plos One, 10, 2015
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3ZKR
 | | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoform | | Descriptor: | CYS-LOOP LIGAND-GATED ION CHANNEL, TRIBROMOMETHANE | | Authors: | Spurny, R, Billen, B, Howard, R.J, Brams, M, Debaveye, S, Price, K.L, Weston, D.A, Strelkov, S.V, Tytgat, J, Bertrand, S, Bertrand, D, Lummis, S.C.R, Ulens, C. | | Deposit date: | 2013-01-24 | | Release date: | 2013-02-06 | | Last modified: | 2014-09-17 | | Method: | X-RAY DIFFRACTION (3.649 Å) | | Cite: | Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia Chrysanthemi Ligand-Gated Ion Channel (Elic).
J.Biol.Chem., 288, 2013
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3ZKT
 | | SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU- CONOTOXIN CnVA | | Descriptor: | TAU-CNVA | | Authors: | Petrel, C, Hocking, H.G, Reynaud, M, Favreau, P, Paolini-Bertrand, M, Peigneur, S, Upert, G, Tytgat, J, Gilles, N, Hartley, O, Boelens, R, Stocklin, R, Servent, D. | | Deposit date: | 2013-01-24 | | Release date: | 2013-04-24 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Identification, Structural and Pharmacological Characterization of Tau-Cnva, a Conopeptide that Selectively Interacts with Somatostatin Sst3 Receptor.
Biochem.Pharmacol, 85, 2013
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1ZYV
 | | Crystal Structure Of Mutant K8DP9SR58KV59G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | | Descriptor: | Alpha-like neurotoxin BmK-I | | Authors: | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | | Deposit date: | 2005-06-12 | | Release date: | 2006-05-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
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1ZU3
 | | Crystal Structure Of Mutant K8A Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | | Descriptor: | Alpha-like neurotoxin BmK-I | | Authors: | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | | Deposit date: | 2005-05-30 | | Release date: | 2006-05-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
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1ZVE
 | | Crystal Structure Of Mutant K8G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | | Descriptor: | ACETATE ION, Alpha-like neurotoxin BmK-I | | Authors: | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | | Deposit date: | 2005-06-01 | | Release date: | 2006-05-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
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1ZVG
 | | Crystal Structure Of Mutant K8DP9S Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | | Descriptor: | Alpha-like neurotoxin BmK-I | | Authors: | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | | Deposit date: | 2005-06-02 | | Release date: | 2006-06-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
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1WQE
 | | An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis | | Descriptor: | OmTx3 | | Authors: | Chagot, B, Pimentel, C, Dai, L, Pil, J, Tytgat, J, Nakajima, T, Corzo, G, Darbon, H, Ferrat, G. | | Deposit date: | 2004-09-28 | | Release date: | 2005-01-18 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis
Biochem.J., 388, 2005
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1WQC
 | | An unusual fold for potassium channel blockers : NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis | | Descriptor: | OmTx1 | | Authors: | Chagot, B, Pimentel, C, Dai, L, Pil, J, Tytgat, J, Nakajima, T, Corzo, G, Darbon, H, Ferrat, G. | | Deposit date: | 2004-09-27 | | Release date: | 2005-01-18 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis
Biochem.J., 388, 2005
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1WQD
 | | An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis | | Descriptor: | OmTx2 | | Authors: | Chagot, B, Pimentel, C, Dai, L, Pil, J, Tytgat, J, Nakajima, T, Corzo, G, Darbon, H, Ferrat, G. | | Deposit date: | 2004-09-28 | | Release date: | 2005-01-18 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis
Biochem.J., 388, 2005
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1V90
 | | Solution structure by NMR means of delta-paluIT1-NH2 | | Descriptor: | Delta-palutoxin IT1 | | Authors: | Ferrat, G, Bosmans, F, Tytgat, J, Pimentel, C, Chagot, B, Nakajima, T, Darbon, H, Corzo, G. | | Deposit date: | 2004-01-19 | | Release date: | 2005-03-29 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of two insect-specific spider toxins and their pharmacological interaction with the insect voltage-gated Na(+) channel
Proteins, 59, 2005
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1V91
 | | Solution structure of insectidal toxin delta-paluIT2-NH2 | | Descriptor: | Delta-palutoxin IT2 | | Authors: | Ferrat, G, Bosmans, F, Tytgat, J, Pimentel, C, Chagot, B, Nakajima, T, Darbon, H, Corzo, G. | | Deposit date: | 2004-01-19 | | Release date: | 2005-03-29 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of two insect-specific spider toxins and their pharmacological interaction with the insect voltage-gated Na(+) channel
Proteins, 59, 2005
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1ZUT
 | | Crystal Structure Of Mutant K8DP9SR58K Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | | Descriptor: | Alpha-like neurotoxin BmK-I, SULFATE ION | | Authors: | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | | Deposit date: | 2005-06-01 | | Release date: | 2006-05-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
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1ZYW
 | | Crystal Structure Of Mutant K8DP9SR58KP60G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | | Descriptor: | ACETATE ION, Alpha-like neurotoxin BmK-I, SULFATE ION | | Authors: | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | | Deposit date: | 2005-06-13 | | Release date: | 2006-05-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
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2GX1
 | | Solution structure and alanine scan of a spider toxin that affects the activation of mammalian sodium channels | | Descriptor: | Neurotoxin magi-5 | | Authors: | Sabo, J.K, Corzo, G, Bosmans, F, Billen, B, Villegas, E, Tytgat, J, Norton, R.S. | | Deposit date: | 2006-05-08 | | Release date: | 2006-12-05 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Solution Structure and Alanine Scan of a Spider Toxin That Affects the Activation of Mammalian Voltage-gated Sodium Channels
J.Biol.Chem., 282, 2007
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2LER
 | | Conotoxin pc16a | | Descriptor: | Conotoxin pc16a | | Authors: | Dyubankova, N, Lescrinier, E, Van Der Haegen, A, Peigneur, S, Tytgat, J. | | Deposit date: | 2011-06-22 | | Release date: | 2012-04-11 | | Last modified: | 2012-04-18 | | Method: | SOLUTION NMR | | Cite: | Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity.
Peptides, 34, 2012
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2LKB
 | | Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels | | Descriptor: | Neurotoxin MeuNaTx-5 | | Authors: | Zhu, S, Peigneur, S, Gao, B, Lu, X, Cao, C, Tytgat, J. | | Deposit date: | 2011-10-09 | | Release date: | 2011-11-02 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels
Mol.Cell Proteomics, 2011
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2LU6
 | | NMR solution structure of Midi peptide designed based on m-conotoxins | | Descriptor: | Midi peptide designed based on m-conotoxins | | Authors: | Dyubankova, N, Lescrinier, E, Stevens, M, Tytgat, J, Herdewijn, P, Peigneur, S. | | Deposit date: | 2012-06-08 | | Release date: | 2012-06-27 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Design of bioactive peptides from naturally occurring mu-conotoxin structures.
J.Biol.Chem., 287, 2012
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2MD6
 | | NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis | | Descriptor: | ALPHA CONOTOXIN LO1A | | Authors: | Maiti, M, Lescrinier, E, Herdewijn, P, Lebbe, E.K.M, Peigneur, S, D'Souza, L, Tytgat, J. | | Deposit date: | 2013-09-01 | | Release date: | 2014-03-05 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structure-Function Elucidation of a New alpha-Conotoxin, Lo1a, from Conus longurionis.
J.Biol.Chem., 289, 2014
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2MSF
 | | NMR SOLUTION STRUCTURE OF SCORPION VENOM TOXIN Ts11 (TsPep1) FROM Tityus serrulatus | | Descriptor: | Peptide TsPep1 | | Authors: | Maiti, M, Lescrinier, E, Herdewijn, P, Cremonez, C.M, Peigneur, S, Cassoli, J.S, Dutra, A.A.A, Waelkens, E, Pimenta, A.M.C, De Lima, M.H, Tytgat, J, Arantes, E.C. | | Deposit date: | 2014-08-01 | | Release date: | 2015-08-26 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins.
Toxins (Basel), 8, 2016
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