Author results

2F6Q
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THE CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3, DELTA2 ENOYL COA ISOMERASE (PECI)
分子名称:Peroxisomal 3,2-trans-enoyl-CoA isomerase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Turnbull, A., Lukacik, P., Shafqat, N., Smee, C., Berridge, G., Guo, K., von Delft, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-11-29
公開日2005-12-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)
To be Published
2P8U
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CRYSTAL STRUCTURE OF HUMAN 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE I
分子名称:Hydroxymethylglutaryl-CoA synthase, cytoplasmic, COENZYME A, ...
著者Turnbull, A., Shafqat, N., Salah, E., Niesen, F.H., Burgess, N., Bunkoczi, G., Debreczeni, J., Pike, A.C.W., Umeano, C., Gorrec, F., von Delft, F., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2007-03-23
公開日2007-04-03
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
J.Mol.Biol., 398, 2010
2C47
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STRUCTURE OF CASEIN KINASE 1 GAMMA 2
分子名称:CASEIN KINASE 1 GAMMA 2 ISOFORM, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, MAGNESIUM ION
著者Bunkoczi, G., Rellos, P., Das, S., Ugochukwu, E., Fedorov, O., Sobott, F., Eswaran, J., Amos, A., Ball, L., von Delft, F., Bullock, A., Debreczeni, J., Turnbull, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2005-10-16
公開日2005-11-07
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Structure of Casein Kinase 1 Gamma 2
To be Published
2EXE
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED CLK3
分子名称:Dual specificity protein kinase CLK3
著者Papagrigoriou, E., Rellos, P., Das, S., Bullock, A., Ball, L.J., Turnbull, A., Savitsky, P., Fedorov, O., Johansson, C., Ugochukwu, E., Sobott, F., von Delft, F., Edwards, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2005-11-08
公開日2005-11-15
最終更新日2012-05-02
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the phosphorylated CLK3
TO BE PUBLISHED
2JAM
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G
分子名称:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G, POLYPEPTIDE, 1,2-ETHANEDIOL, ...
著者Debreczeni, J.E., Bullock, A., Keates, T., Niesen, F.H., Salah, E., Shrestha, L., Smee, C., Sobott, F., Pike, A.C.W., Bunkoczi, G., von Delft, F., Turnbull, A., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
登録日2006-11-29
公開日2007-03-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G
To be Published
2B05
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CRYSTAL STRUCTURE OF 14-3-3 GAMMA IN COMPLEX WITH A PHOSPHOSERINE PEPTIDE
分子名称:14-3-3 protein gamma, peptide
著者Papagrigoriou, E., Elkins, J., Arrowsmith, C., Zhao, Y., Debreczeni, E.J., Edwards, A., Weigelt, J., Doyle, D., von Delft, F., Turnbull, A., Yang, X.
登録日2005-09-13
公開日2005-10-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal Structure of 14-3-3 gamma in complex with a phosphoserine peptide
TO BE PUBLISHED
2C9Y
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STRUCTURE OF HUMAN ADENYLATE KINASE 2
分子名称:ADENYLATE KINASE ISOENZYME 2, MITOCHONDRIAL, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ...
著者Bunkoczi, G., Filippakopoulos, P., Debreczeni, J.E., Turnbull, A., Papagrigoriou, E., Savitsky, P., Colebrook, S., von Delft, F., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
登録日2005-12-15
公開日2006-01-04
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of Human Adenylate Kinase 2
To be Published
2CLP
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CRYSTAL STRUCTURE OF HUMAN AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3
分子名称:AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION
著者Debreczeni, J.E., Marsden, B.D., Johansson, C., Kavanagh, K., Guo, K., Smee, C., Gileadi, O., Turnbull, A., Papagrigoriou, E., von Delft, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Oppermann, U.
登録日2006-04-28
公開日2006-05-12
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structure of Human Aflatoxin B1 Aldehyde Reductase Member 3
To be Published
2ERY
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THE CRYSTAL STRUCTURE OF THE RAS RELATED PROTEIN RRAS2 (RRAS2) IN THE GDP BOUND STATE
分子名称:Ras-related protein R-Ras2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Salah, E., Schoch, G., Turnbull, A., Papagrigoriou, E., Soundararajan, M., Burgess, N., Elkins, J., Gileadi, C., Gileadi, O., von Delft, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2005-10-25
公開日2005-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state
To be Published
2F5Y
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN FROM HUMAN RGS-3
分子名称:regulator of G-protein signalling 3 isoform 1, SULFATE ION
著者Ugochukwu, E., Berridge, G., Johansson, C., Smee, C., Savitsky, P., Burgess, N., Colebrook, S., Yang, X., Elkins, J., Doyle, D., Turnbull, A., Papagrigoriou, E., Debreczeni, J., Bunkoczi, G., Gorrec, F., von Delft, F., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., Structural Genomics Consortium (SGC)
登録日2005-11-28
公開日2005-12-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Crystal Structure of the PDZ Domain from Human RGS-3
To be Published
2FE5
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THE CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF HUMAN DLG3
分子名称:Presynaptic protein SAP102, SULFATE ION, GLYCEROL
著者Ugochukwu, E., Phillips, C., Schoch, G., Berridge, G., Salah, E., Colebrook, S., Smee, C., Savitsky, P., Bray, J., Elkins, J., Doyle, D., Bunkoczi, G., Debreczeni, J., Turnbull, A., Gorrec, F., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Structural Genomics Consortium (SGC)
登録日2005-12-15
公開日2005-12-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The Crystal Structure of the Second PDZ Domain of Human DLG3
To be Published
2J0I
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4
分子名称:SERINE/THREONINE-PROTEIN KINASE PAK 4, 1,2-ETHANEDIOL
著者Debreczeni, J.E., Eswaran, J., Ugochukwu, E., Papagrigoriou, E., Turnbull, A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Knapp, S.
登録日2006-08-03
公開日2006-08-17
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of the Human P21-Activated Kinase 4
To be Published
2NPT
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CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE KINASE 5 PHOX DOMAIN (MAP2K5-PHOX) WITH HUMAN MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2 PHOX DOMAIN (MAP3K2-PHOX)
分子名称:Dual specificity mitogen-activated protein kinase kinase 5, Mitogen-activated protein kinase kinase kinase 2
著者Filippakopoulos, P., Debreczeni, J., Papagrigoriou, V., Turnbull, A., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
登録日2006-10-30
公開日2006-11-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)
To be Published
2NZL
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CRYSTAL STRUCTURE OF HUMAN HYDROXYACID OXIDASE 1
分子名称:Hydroxyacid oxidase 1, FLAVIN MONONUCLEOTIDE, GLYOXYLIC ACID
著者Ugochukwu, E., Kavanagh, K., Pilka, E., Berridge, G., Debreczeni, J.E., Papagrigoriou, E., Turnbull, A., Niesen, F., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2006-11-24
公開日2006-12-12
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Crystal structure of human hydroxyacid oxidase 1
To be Published
2OBV
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CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT
分子名称:S-adenosylmethionine synthetase isoform type-1, SODIUM ION, S-ADENOSYLMETHIONINE, ...
著者Pilka, E.S., Shafqat, N., Kavanagh, K.L., Cooper, C., Hozjan, V., Turnbull, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2006-12-20
公開日2007-01-02
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
To be Published
2OVJ
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THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATING PROTEIN 1 (RACGAP1) MGCRACGAP.
分子名称:Rac GTPase-activating protein 1, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
著者Shrestha, L., Papagrigoriou, E., Soundararajan, M., Elkins, J., Johansson, C., von Delft, F., Pike, A.C.W., Burgess, N., Turnbull, A., Debreczeni, J., Gorrec, F., Umeano, C., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2007-02-14
公開日2007-02-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP.
To be Published
2Q0N
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STRUCTURE OF HUMAN P21 ACTIVATING KINASE 4 (PAK4) IN COMPLEX WITH A CONSENSUS PEPTIDE
分子名称:Serine/threonine-protein kinase PAK 4, Synthetic peptide, SULFATE ION, ...
著者Filippakopoulos, P., Eswaran, J., Turnbull, A., Papagrigoriou, E., Pike, A.W., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
登録日2007-05-22
公開日2007-06-26
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide.
To be Published
2UYY
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STRUCTURE OF THE CYTOKINE-LIKE NUCLEAR FACTOR N-PAC
分子名称:N-PAC PROTEIN, POTASSIUM ION, [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
著者Tickle, J., Pilka, E.S., Bunkoczi, G., Berridge, G., Smee, C., Kavanagh, K.L., Hozjan, V., Niesen, F.H., Papagrigoriou, E., Pike, A.C.W., Turnbull, A., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., von Delft, F., Oppermann, U.
登録日2007-04-20
公開日2007-07-03
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Structure of the Cytokine-Like Nuclear Factor N-Pac
To be Published
3QFV
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MRCK BETA IN COMPLEX WITH TPCA-1
分子名称:CDC42BPB protein, 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide, 1,2-ETHANEDIOL, ...
著者Heikkila, T.J., Wheatley, E., Crighton, D., Schroder, E., Boakes, A., Kaye, S.J., Mezna, M., Pang, L., Rushbrooke, M., Turnbull, A., Olson, M.F.
登録日2011-01-23
公開日2011-10-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Co-crystal structures of inhibitors with MRCK beta , a key regulator of tumor cell invasion.
Plos One, 6, 2011
2C30
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 6
分子名称:SERINE/THREONINE-PROTEIN KINASE PAK 6, PHOSPHATE ION, CHLORIDE ION
著者Filippakopoulos, P., Berridge, G., Bray, J., Burgess, N., Colebrook, S., Das, S., Eswaran, J., Gileadi, O., Papagrigoriou, E., Savitsky, P., Smee, C., Turnbull, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Knapp, S.
登録日2005-10-02
公開日2006-02-08
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
2F57
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 5
分子名称:Serine/threonine-protein kinase PAK 7, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE
著者Eswaran, J., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Bray, J., Das, S., Savitsky, P., Smee, C., Burgess, N., Fedorov, O., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Weigelt, J., Sundstrom, M., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
登録日2005-11-25
公開日2005-12-13
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
Structure, 15, 2007
3TKU
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MRCK BETA IN COMPLEX WITH FASUDIL
分子名称:Serine/threonine-protein kinase MRCK beta, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, 1,2-ETHANEDIOL
著者Heikkila, T.J., Turnbull, A., Wheatley, E., Schroder, E., Crighton, D., Olson, M.F.
登録日2011-08-29
公開日2011-10-05
最終更新日2012-04-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Co-crystal structures of inhibitors with MRCK, a key regulator of tumor cell invasion
Plos One, 6, 2011
2REY
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN DISHEVELLED 2 (HOMOLOGOUS TO DROSOPHILA DSH)
分子名称:Segment polarity protein dishevelled homolog DVL-2
著者Papagrigoriou, E., Gileadi, C., Elkins, J., Cooper, C., Ugochukwu, E., Turnbull, A., Pike, A.C.W., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2007-09-27
公開日2007-10-23
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh).
To be Published
5LIA
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CRYSTAL STRUCTURE OF MURINE AUTOTAXIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
分子名称:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Turnbull, A.P., Shah, P., Cheasty, A., Raynham, T., Pang, L., Owen, P.
登録日2016-07-14
公開日2016-11-09
最終更新日2016-12-28
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Discovery of potent inhibitors of the lysophospholipase autotaxin.
Bioorg. Med. Chem. Lett., 26, 2016
2ES0
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS6
分子名称:regulator of G-protein signalling 6
著者Schoch, G.A., Phillips, C., Turnbull, A., Niesen, F., Johansson, C., Elkins, J.M., Longman, E., Gilealdi, C., Sobott, F., Ball, L., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2005-10-25
公開日2005-11-29
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008