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4NZQ
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CRYSTAL STRUCTURE OF CA2+-FREE PROTHROMBIN DELETION MUTANT RESIDUES 146-167
Descriptor:Prothrombin, N-ACETYL-D-GLUCOSAMINE
Authors:Pozzi, N., Chen, Z., Shropshire, D.B., Pelc, L.A., Di Cera, E.
Deposit date:2013-12-12
Release date:2014-05-21
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
4DIH
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X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND THROMBIN BINDING APTAMER IN THE PRESENCE OF SODIUM IONS
Descriptor:Prothrombin, Thrombin binding aptamer, ZINC ION, ...
Authors:Russo Krauss, I., Merlino, A., Mazzarella, L., Sica, F.
Deposit date:2012-01-31
Release date:2012-07-18
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.
Nucleic Acids Res., 40, 2012
4DII
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X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND THROMBIN BINDING APTAMER IN THE PRESENCE OF POTASSIUM IONS
Descriptor:Prothrombin, Thrombin binding aptamer, ZINC ION, ...
Authors:Russo Krauss, I., Merlino, A., Mazzarella, L., Sica, F.
Deposit date:2012-01-31
Release date:2012-07-18
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.
Nucleic Acids Res., 40, 2012
3SQE
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CRYSTAL STRUCTURE OF PRETHROMBIN-2 MUTANT S195A IN THE ALTERNATIVE FORM
Descriptor:Thrombin light chain, heavy chain, GLYCEROL
Authors:Pozzi, N., Chen, Z., Di Cera, E.
Deposit date:2011-07-05
Release date:2011-11-30
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation.
Biochemistry, 50, 2011
3SQH
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CRYSTAL STRUCTURE OF PRETHROMBIN-2 MUTANT S195A IN THE THE OPEN FORM
Descriptor:Thrombin light chain, heavy chain
Authors:Pozzi, N., Chen, Z., Di Cera, E.
Deposit date:2011-07-05
Release date:2011-11-30
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation.
Biochemistry, 50, 2011
2P3F
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CRYSTAL STRUCTURE OF THE FACTOR XA/NAP5 COMPLEX
Descriptor:Coagulation factor X, Anti-coagulant protein 5, SODIUM ION
Authors:Rios-Steiner, J.L., Murakami, M.T., Tulinsky, A., Arni, R.K.
Deposit date:2007-03-08
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Active and exo-site inhibition of human factor Xa: structure of des-Gla factor Xa inhibited by NAP5, a potent nematode anticoagulant protein from Ancylostoma caninum
J.Mol.Biol., 371, 2007
2H9E
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CRYSTAL STRUCTURE OF FXA/SELECTIDE/NAPC2 TERNARY COMPLEX
Descriptor:Coagulation factor X heavy chain, Coagulation factor X light chain, Anti-coagulant protein C2, ...
Authors:Murakami, M.T., Geiger, G., Tulinsky, A., Arni, R.K.
Deposit date:2006-06-09
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Intermolecular Interactions and Characterization of the Novel Factor Xa Exosite Involved in Macromolecular Recognition and Inhibition: Crystal Structure of Human Gla-domainless Factor Xa Complexed with the Anticoagulant Protein NAPc2 from the Hematophagous Nematode Ancylostoma caninum.
J.Mol.Biol., 366, 2007
1WU1
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL) PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2004-11-29
Release date:2005-11-29
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
Bioorg.Med.Chem., 13, 2005
1TWX
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CRYSTAL STRUCTURE OF THE THROMBIN MUTANT D221A/D222K
Descriptor:Prothrombin, Hirudin, N-ACETYL-D-GLUCOSAMINE
Authors:Pineda, A.O., Zhang, E., Guinto, E.R., Savvides, S.N., Tulinsky, A., Di Cera, E.
Deposit date:2004-07-01
Release date:2005-04-19
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form
Biophys.Chem., 112, 2004
1V3X
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-[6-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO(5,4-C)PYRIDIN-2-YL] CARBONYL-2-CARBAMOYL-4-(6-CHLORONAPHTH-2-YLSULPHONYL)PIPERAZINE
Descriptor:Coagulation factor X, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Suzuki, M.
Deposit date:2003-11-07
Release date:2004-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element
J.Med.Chem., 47, 2004
1NY2
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HUMAN ALPHA THROMBIN INHIBITED BY RPPGF AND HIRUGEN
Descriptor:thrombin light chain, thrombin Heavy chain, Hirugen, ...
Authors:Krishnan, R., Tulinsky, A., Schmaier, A.H., Hasan, A.A., Warnock, M., Srikanth, S., Mahdi, F.
Deposit date:2003-02-11
Release date:2003-03-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin.
Am.J.Physiol.Heart Circ.Physiol., 285, 2003
1MXS
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CRYSTAL STRUCTURE OF 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE (KDPG) ALDOLASE FROM PSEUDOMONAS PUTIDA.
Descriptor:KDPG Aldolase, SULFATE ION
Authors:Watanabe, L., Bell, B.J., Lebioda, L., Rios-Steiner, J.L., Tulinsky, A., Arni, R.K.
Deposit date:2002-10-03
Release date:2003-09-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida.
Acta Crystallogr.,Sect.D, 59, 2003
1KI0
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THE X-RAY STRUCTURE OF HUMAN ANGIOSTATIN
Descriptor:ANGIOSTATIN, BICINE
Authors:Abad, M.C., Arni, R.K., Grella, D.K., Castellino, F.J., Tulinsky, A., Geiger, J.H.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.
J.Mol.Biol., 318, 2002
1IQE
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55590
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[(2R)-3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-1-OXO-2-[[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]AMINO]PROPYL]-THIOMORPHOLINE-1,1-DIOXIDE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQF
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55165
Descriptor:coagulation Factor Xa, CALCIUM ION, (2R)-4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQG
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55159
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYIMINOMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQH
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55143
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQI
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55125
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL] METHYL]-2-PIPERAZINECARBOXYLIC ACID
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQJ
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55124
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQK
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55113
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQL
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M54476
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQM
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M54471
Descriptor:coagulation Factor Xa, CALCIUM ION, 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQN
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55192
Descriptor:coagulation Factor Xa, CALCIUM ION, 4-[[4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINYL]CARBONYL]MORPHOLINE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1JBU
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COAGULATION FACTOR VII ZYMOGEN (EGF2/PROTEASE) IN COMPLEX WITH INHIBITORY EXOSITE PEPTIDE A-183
Descriptor:COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, SULFATE ION, ...
Authors:Eigenbrot, C., Kirchhofer, D., Dennis, M.S., Santell, L., Lazarus, R.A., Stamos, J., Ultsch, M.H.
Deposit date:2001-06-06
Release date:2001-07-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
1IOE
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HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55532
Descriptor:COAGULATION FACTOR XA, CALCIUM ION, (-)-7-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]TETRAHYDRO-8A-(METHOXYMETHYL)-1'-(4-PYRIDINYL)-SPIRO[5H-OXAZOLO[3,2-A]PYRAZINE-2(3H),4'-PIPERIDIN]-5-ONE
Authors:Shiromizu, I., Matsusue, T.
Deposit date:2001-03-08
Release date:2003-09-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Factor Xa Specific Inhibitor That Induces the Novel Binding Model In Complex With Human FXa
To be Published