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6C2Q
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BU of 6c2q by Molmil
Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PLP-L-Serine Intermediate
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Kreinbring, C.A, Tu, Y, Liu, D, Petsko, G.A, Ringe, D.
Deposit date:2018-01-08
Release date:2018-04-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
6C2H
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BU of 6c2h by Molmil
Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the Catalytic Core
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Kreinbring, C.A, Tu, Y, Liu, D, Petsko, G.A, Ringe, D.
Deposit date:2018-01-08
Release date:2018-04-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
6C4P
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BU of 6c4p by Molmil
Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PMP Complex
Descriptor: 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, CALCIUM ION, ...
Authors:Kreinbring, C.A, Tu, Y, Liu, D, Berkowitz, D.B, Petsko, G.A, Ringe, D.
Deposit date:2018-01-12
Release date:2018-04-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
6C2Z
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BU of 6c2z by Molmil
Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PLP-Aminoacrylate Intermediate
Descriptor: 1,2-ETHANEDIOL, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CALCIUM ION, ...
Authors:Kreinbring, C.A, Tu, Y, Liu, D, Petsko, G.A, Ringe, D.
Deposit date:2018-01-09
Release date:2018-04-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
4AJT
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BU of 4ajt by Molmil
The crystal structure of mouse protein-Z dependent protease inhibitor(mZPI)
Descriptor: PROTEIN Z-DEPENDENT PROTEASE INHIBITOR
Authors:Yan, Y, Zhou, A.
Deposit date:2012-02-19
Release date:2012-12-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z.
Blood, 120, 2012
4AJU
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BU of 4aju by Molmil
Crystal structure of the reactive loop cleaved ZPI in P41 space group
Descriptor: 1,2-ETHANEDIOL, PROTEIN Z-DEPENDENT PROTEASE INHIBITOR, SULFATE ION
Authors:Zhou, A, Yan, Y, Wei, Z.
Deposit date:2012-02-19
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z.
Blood, 120, 2012
4AFX
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BU of 4afx by Molmil
Crystal structure of the reactive loop cleaved ZPI in I2 space group
Descriptor: CALCIUM ION, PHOSPHATE ION, PROTEIN Z DEPENDENT PROTEASE INHIBITOR, ...
Authors:Zhou, A, Yan, Y, Wei, Z.
Deposit date:2012-01-23
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z.
Blood, 120, 2012
6JLH
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BU of 6jlh by Molmil
Structure of SCGN in complex with a Snap25 peptide
Descriptor: CALCIUM ION, CHLORIDE ION, Secretagogin, ...
Authors:Qin, J, Sun, Q, Jia, D.
Deposit date:2019-03-05
Release date:2020-03-11
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural and mechanistic insights into secretagogin-mediated exocytosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
7U2U
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BU of 7u2u by Molmil
CRYSTAL STRUCTURE OF HIV-1 INTEGRASE COMPLEXED WITH Compound-2a AKA (2S)-2-(TERT-BUTOXY)-2-[7-(4,4-DIMETHYLPIPE RIDIN-1-YL)-8-{4-[2-(4-FLUOROPHENYL)ETHOXY]PHENYL}-2,5-DIM ETHYLIMIDAZO[1,2-A]PYRIDIN-6-YL]ACETIC ACID
Descriptor: (2S)-tert-butoxy[(4S)-7-(4,4-dimethylpiperidin-1-yl)-8-{4-[2-(4-fluorophenyl)ethoxy]phenyl}-2,5-dimethylimidazo[1,2-a]pyridin-6-yl]acetic acid, Integrase, SULFATE ION
Authors:Khan, J.A, lewis, H, Kish, K.
Deposit date:2022-02-24
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.839 Å)
Cite:Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg.Med.Chem., 67, 2022
4NWK
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BU of 4nwk by Molmil
Crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r,2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6-methoxy-1-isoquinolinyl)ox y)-l-prolinamide
Descriptor: GLYCEROL, HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide, ...
Authors:Muckelbauer, J.K, Klei, H.E.
Deposit date:2013-12-06
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J.Med.Chem., 57, 2014
4NLD
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BU of 4nld by Molmil
Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with BMS-791325 also known as (1aR,12bS)-8-cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-n-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide
Descriptor: (1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase, ...
Authors:Sheriff, S.
Deposit date:2013-11-14
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase.
J.Med.Chem., 57, 2014
4NWL
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BU of 4nwl by Molmil
Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide
Descriptor: HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-L-prolinamide, ZINC ION
Authors:Muckelbauer, J.K, Klei, H.E.
Deposit date:2013-12-06
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J.Med.Chem., 57, 2014
6WT3
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BU of 6wt3 by Molmil
Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase
Descriptor: 5D2 FAB HEAVY CHAIN, 5D2 FAB LIGHT CHAIN
Authors:Luz, J.G, Birrane, G, Young, S.G, Meiyappan, M, Ploug, M.
Deposit date:2020-05-01
Release date:2020-07-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase.
J.Lipid Res., 61, 2020
6WN4
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BU of 6wn4 by Molmil
Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase
Descriptor: 5D2 FAB HEAVY CHAIN, 5D2 FAB LIGHT CHAIN, Lipoprotein lipase peptide
Authors:Luz, J.G, Birrane, G, Young, S.G, Meiyappan, M, Ploug, M.
Deposit date:2020-04-22
Release date:2020-07-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase.
J.Lipid Res., 61, 2020
3P9K
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BU of 3p9k by Molmil
Crystal structure of perennial ryegrass LpOMT1 complexed with S-adenosyl-L-homocysteine and coniferaldehyde
Descriptor: (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal, Caffeic acid O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Louie, G.V, Noel, J.P, Bowman, M.E.
Deposit date:2010-10-17
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference.
Plant Cell, 22, 2010
3P9C
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BU of 3p9c by Molmil
Crystal structure of perennial ryegrass LpOMT1 bound to SAH
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Louie, G.V, Noel, J.P, Bowman, M.E.
Deposit date:2010-10-17
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference.
Plant Cell, 22, 2010
3P9I
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BU of 3p9i by Molmil
Crystal structure of perennial ryegrass LpOMT1 complexed with S-adenosyl-L-homocysteine and sinapaldehyde
Descriptor: (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enal, BETA-MERCAPTOETHANOL, Caffeic acid O-methyltransferase, ...
Authors:Louie, G.V, Noel, J.P, Bowman, M.E.
Deposit date:2010-10-17
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference.
Plant Cell, 22, 2010
7X1Z
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BU of 7x1z by Molmil
Structure of the phosphorylation-site double mutant S431E/T432E of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION
Authors:Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q.
Deposit date:2022-02-25
Release date:2023-04-19
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex
Nat Commun, 14, 2023
7X1Y
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BU of 7x1y by Molmil
Structure of the phosphorylation-site double mutant S431A/T432A of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION
Authors:Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q.
Deposit date:2022-02-25
Release date:2023-04-26
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex
Nat Commun, 14, 2023
6AKR
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BU of 6akr by Molmil
Crystal structure of the PDE4D catalytic domain in complex with osthole
Descriptor: 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Authors:Wang, S, Huo, Y.W, Xie, Y.
Deposit date:2018-09-03
Release date:2020-02-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.326 Å)
Cite:Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma.
Sci.Signal., 13, 2020
2MPK
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BU of 2mpk by Molmil
Characterization and structure of the MIT1 domain of a chitin synthase from the Oomycete Saprolegnia monoica
Descriptor: Chitin synthase 1
Authors:Bulone, V, Szpryngiel, S, Brown, C, Ye, W.
Deposit date:2014-05-27
Release date:2015-05-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural and functional characterization of the microtubule interacting and trafficking domains of two oomycete chitin synthases.
Febs J., 283, 2016
5YI8
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BU of 5yi8 by Molmil
Crystal structure of drosophila Numb PTB domain and Pon peptide complex
Descriptor: FORMIC ACID, Pon peptide from Partner of numb, Protein numb
Authors:Shan, Z, Wen, W.
Deposit date:2017-10-03
Release date:2018-04-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
Nat Commun, 9, 2018
5YI7
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BU of 5yi7 by Molmil
Crystal structure of drosophila Numb PTB domain and Pon peptide complex
Descriptor: GLYCEROL, Pon peptide from Partner of numb, Protein numb
Authors:Shan, Z, Wen, W.
Deposit date:2017-10-03
Release date:2018-04-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
Nat Commun, 9, 2018
1U5S
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BU of 1u5s by Molmil
NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain
Descriptor: Cytoplasmic protein NCK2, PINCH protein, ZINC ION
Authors:Vaynberg, J, Fukuda, T, Vinogradova, O, Velyvis, A, Ng, L, Wu, C, Qin, J.
Deposit date:2004-07-28
Release date:2005-04-05
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility.
Mol.Cell, 17, 2005
3B3W
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BU of 3b3w by Molmil
Crystal structure of the S228A mutant of the aminopeptidase from Vibrio proteolyticus in complex with leucine
Descriptor: Bacterial leucyl aminopeptidase, LEUCINE, SODIUM ION, ...
Authors:Ataie, N.J, Hoang, Q.Q, Zahniser, M.P.D, Milne, A, Petsko, G.A, Ringe, D.
Deposit date:2007-10-22
Release date:2007-11-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus.
Biochemistry, 47, 2008

 

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