Author results

3R9W
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CRYSTAL STRUCTURE OF ERA IN COMPLEX WITH MGGDPNP AND NUCLEOTIDES 1506-1542 OF 16S RIBOSOMAL RNA
Descriptor:GTPase Era, RNA301, MAGNESIUM ION, ...
Authors:Tu, C., Ji, X.
Deposit date:2011-03-26
Release date:2011-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA.
Proc.Natl.Acad.Sci.USA, 108, 2011
3R9X
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CRYSTAL STRUCTURE OF ERA IN COMPLEX WITH MGGDPNP, NUCLEOTIDES 1506-1542 OF 16S RIBOSOMAL RNA, AND KSGA
Descriptor:GTPase Era, Ribosomal RNA small subunit methyltransferase A, RNA301, ...
Authors:Tu, C., Ji, X.
Deposit date:2011-03-26
Release date:2011-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA.
Proc.Natl.Acad.Sci.USA, 108, 2011
2PCX
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CRYSTAL STRUCTURE OF P53DBD(R282Q) AT 1.54-ANGSTROM RESOLUTION
Descriptor:Cellular tumor antigen p53, ZINC ION
Authors:Tu, C., Shaw, G., Ji, X.
Deposit date:2007-03-30
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution.
Acta Crystallogr.,Sect.D, 64, 2008
3FTC
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CRYSTAL STRUCTURE OF A. AEOLICUS KSGA AT 1.72-ANGSTROM RESOLUTION
Descriptor:Dimethyladenosine transferase
Authors:Tu, C., Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
3FTD
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CRYSTAL STRUCTURE OF A. AEOLICUS KSGA AT 1.44-ANGSTROM RESOLUTION
Descriptor:Dimethyladenosine transferase
Authors:Tu, C., Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
3FTE
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CRYSTAL STRUCTURE OF A. AEOLICUS KSGA IN COMPLEX WITH RNA
Descriptor:Dimethyladenosine transferase, 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3'
Authors:Tu, C., Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
3FTF
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CRYSTAL STRUCTURE OF A. AEOLICUS KSGA IN COMPLEX WITH RNA AND SAH
Descriptor:Dimethyladenosine transferase, 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3', S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Tu, C., Ji, X.
Deposit date:2009-01-12
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
3IEU
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CRYSTAL STRUCTURE OF ERA IN COMPLEX WITH GDP
Descriptor:GTP-binding protein era, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Tu, C., Ji, X.
Deposit date:2009-07-23
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis
Proc.Natl.Acad.Sci.USA, 106, 2009
3IEV
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CRYSTAL STRUCTURE OF ERA IN COMPLEX WITH MGGNP AND THE 3' END OF 16S RRNA
Descriptor:GTP-binding protein era, 5'-R(P*AP*UP*CP*AP*CP*CP*UP*CP*CP*UP*UP*A)-3', MAGNESIUM ION, ...
Authors:Tu, C., Ji, X.
Deposit date:2009-07-23
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis
Proc.Natl.Acad.Sci.USA, 106, 2009
5C2B
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ANTI-CXCL13 PARENTAL SCFV - 3B4
Descriptor:scFv 3B4 heavy chain, 3B4 light chain, CHLORIDE ION
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-15
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.4049 Å)
Cite:Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair
To Be Published
5C6W
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ANTI-CXCL13 SCFV - E10
Descriptor:Protein IGHV1-69-2,Ig lambda chain V-II region NIG-84, CHLORIDE ION, SULFATE ION, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-23
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair
To Be Published
5CBA
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3B4 IN COMPLEX WITH CXCL13 - 3B4-CXCL13
Descriptor:3b4 heavy chain, 3b4 light chain, C-X-C motif chemokine 13, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J. Biol. Chem., 291, 2016
5CBE
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E10 IN COMPLEX WITH CXCL13
Descriptor:E10 heavy chain, E10 light chain, C-X-C motif chemokine 13, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J. Biol. Chem., 291, 2016
4GLR
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STRUCTURE OF THE ANTI-PTAU FAB (PT231/PS235_1) IN COMPLEX WITH PHOSPHOEPITOPE PT231/PS235
Descriptor:phospho-peptide, anti-ptau heavy chain, anti-ptau light chain, ...
Authors:Tu, C., Mosyak, L., Bard, J.
Deposit date:2012-08-14
Release date:2012-11-21
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition.
J.Biol.Chem., 287, 2012
1KEQ
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CRYSTAL STRUCTURE OF F65A/Y131C CARBONIC ANHYDRASE V, COVALENTLY MODIFIED WITH 4-CHLOROMETHYLIMIDAZOLE
Descriptor:F65A/Y131C-MI Carbonic Anhydrase V, POTASSIUM ION, ZINC ION, ...
Authors:Jude, K.M., Wright, S.K., Tu, C., Silverman, D.N., Viola, R.E., Christianson, D.W.
Deposit date:2001-11-16
Release date:2002-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
1TB0
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, CHLORIDE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-19
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.
Biochemistry, 44, 2005
1Z93
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HUMAN CARBONIC ANHYDRASE III:STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
Descriptor:Carbonic anhydrase III, ZINC ION
Authors:Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
Deposit date:2005-03-31
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
1Z97
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HUMAN CARBONIC ANHYDRASE III: STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
Descriptor:Carbonic anhydrase III, ZINC ION
Authors:Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
Deposit date:2005-03-31
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
3L14
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH ALTHIAZIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE
Authors:Quirit, J.G., Robbins, A., Genis, C., Tu, C., Silverman, D.N., McKenna, R.
Deposit date:2009-12-10
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:The Promiscuous Nature of Althiazide in Adducts with CA II and CA IX Mimic
To be Published
1YO0
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PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, CHLORIDE ION
Authors:Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
1YO1
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PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, SULFATE ION, ZINC ION
Authors:Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
1YO2
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PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Bhatt, D., Tu, C., Fisher, S.Z., Hernandez Prada, J.A., McKenna, R., Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
2A8C
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HAEMOPHILUS INFLUENZAE BETA-CARBONIC ANHYDRASE
Descriptor:Carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Cronk, J.D., Rowlett, R.S., Zhang, K.Y.J., Tu, C., Endrizzi, J.A., Lee, J., Gareiss, P.C., Preiss, J.R.
Deposit date:2005-07-07
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase
Biochemistry, 45, 2006
2A8D
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HAEMOPHILUS INFLUENZAE BETA-CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE
Descriptor:Carbonic anhydrase 2, ZINC ION, BICARBONATE ION, ...
Authors:Cronk, J.D., Rowlett, R.S., Zhang, K.Y.J., Tu, C., Endrizzi, J.A., Lee, J., Gareiss, P.C., Preiss, J.R.
Deposit date:2005-07-07
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase
Biochemistry, 45, 2006
2ESF
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IDENTIFICATION OF A NOVEL NON-CATALYTIC BICARBONATE BINDING SITE IN EUBACTERIAL BETA-CARBONIC ANHYDRASE
Descriptor:Carbonic anhydrase 2, ZINC ION, BICARBONATE ION
Authors:Cronk, J.D., Rowlett, R.S., Zhang, K.Y.J., Tu, C., Endrizzi, J.A., Gareiss, P.C.
Deposit date:2005-10-26
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase.
Biochemistry, 45, 2006