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8CTG
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BU of 8ctg by Molmil
Extracellular architecture of an engineered canonical Wnt signaling ternary complex
Descriptor: Frizzled-8, Low-density lipoprotein receptor-related protein 6, PALMITOLEIC ACID, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-14
Release date:2023-03-15
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
6WW2
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BU of 6ww2 by Molmil
Structure of human Frizzled5 by fiducial-assisted cryo-EM
Descriptor: Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ...
Authors:Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
Deposit date:2020-05-07
Release date:2020-08-19
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Elife, 9, 2020
8G04
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BU of 8g04 by Molmil
Structure of signaling thrombopoietin-MPL receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ...
Authors:Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
Deposit date:2023-01-31
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
Cell(Cambridge,Mass.), 186, 2023
7RKN
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BU of 7rkn by Molmil
Structure of CX3CL1-US28-Gi-scFv16 in OC-state
Descriptor: Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKM
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BU of 7rkm by Molmil
Structure of CX3CL1-US28-Gi-scFv16 in C-state
Descriptor: Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKX
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BU of 7rkx by Molmil
Structure of US27-Gi-scFv16 in CL-state
Descriptor: Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKY
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BU of 7rky by Molmil
Binding mode of US27-Gi-scFv16 in OCL-state
Descriptor: Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKF
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BU of 7rkf by Molmil
Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ...
Authors:Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
3WO4
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BU of 3wo4 by Molmil
Crystal structure of the IL-18 signaling ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
3WO2
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BU of 3wo2 by Molmil
Crystal structure of human interleukin-18
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
3WO3
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BU of 3wo3 by Molmil
Crystal structure of IL-18 in complex with IL-18 receptor alpha
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
7JHJ
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BU of 7jhj by Molmil
Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi
Descriptor: Antibody fragment scFv16, BILF1, CHOLESTEROL HEMISUCCINATE, ...
Authors:Tsutsumi, N, Qu, Q.H, Skiniotis, G, Garcia, K.C.
Deposit date:2020-07-20
Release date:2021-07-07
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1.
Immunity, 54, 2021
8FFE
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BU of 8ffe by Molmil
Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide
Descriptor: GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ...
Authors:Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C.
Deposit date:2022-12-08
Release date:2023-03-08
Last modified:2023-03-22
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
6X93
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BU of 6x93 by Molmil
Interleukin-10 signaling complex with IL-10RA and IL-10RB
Descriptor: Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta
Authors:Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C.
Deposit date:2020-06-02
Release date:2021-03-17
Last modified:2021-03-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Science, 371, 2021
7T6F
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BU of 7t6f by Molmil
Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Descriptor: ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ...
Authors:Glassman, C.R, Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-12-13
Release date:2022-03-16
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Science, 376, 2022
7U7N
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BU of 7u7n by Molmil
IL-27 quaternary receptor signaling complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ...
Authors:Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C.
Deposit date:2022-03-07
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structure of the IL-27 quaternary receptor signaling complex.
Elife, 11, 2022
5WB2
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BU of 5wb2 by Molmil
US28 bound to engineered chemokine CX3CL1.35 and nanobodies
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ...
Authors:Jude, K.M, Burg, J.S, Tsutsumi, N, Miles, T.F, Garcia, K.C.
Deposit date:2017-06-27
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
Elife, 7, 2018
5WB1
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BU of 5wb1 by Molmil
Ligand-free US28 with stabilizing intracellular nanobody
Descriptor: Envelope protein US28, nanobody 7 fusion protein
Authors:Jude, K.M, Burg, J.S, Garcia, K.C.
Deposit date:2017-06-27
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.508 Å)
Cite:Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
Elife, 7, 2018
6E3K
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BU of 6e3k by Molmil
Interferon gamma signalling complex with IFNGR1 and IFNGR2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jude, K.M, Mendoza, J.L, Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6E3L
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BU of 6e3l by Molmil
Interferon gamma signalling complex with IFNGR1 and IFNGR2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ...
Authors:Jude, K.M, Mendoza, J.L, Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6WJC
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BU of 6wjc by Molmil
Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex
Descriptor: (1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL (2R)-3-HYDROXY-2-PHENYLPROPANOATE, ACETAMIDE, CHOLESTEROL HEMISUCCINATE, ...
Authors:Maeda, S, Kobilka, B.K.
Deposit date:2020-04-13
Release date:2020-07-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and selectivity engineering of the M1muscarinic receptor toxin complex.
Science, 369, 2020
8EWY
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BU of 8ewy by Molmil
Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Descriptor: ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ...
Authors:Caveney, N.A, Saxton, R.A, Waghray, D, Garcia, K.C.
Deposit date:2022-10-24
Release date:2023-03-08
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structural basis of Janus kinase trans-activation.
Cell Rep, 42, 2023
8FX4
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BU of 8fx4 by Molmil
GC-C-Hsp90-Cdc37 regulatory complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Guanylyl cyclase C, Heat shock protein HSP 90-beta, ...
Authors:Caveney, N.A, Garcia, K.C.
Deposit date:2023-01-23
Release date:2023-07-12
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
Elife, 12, 2023
8HPJ
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BU of 8hpj by Molmil
Crystal structure of the bacterial oxalate transporter OxlT in a ligand-free outward-facing form
Descriptor: Fv fragment Heavy chain, Fv fragment Light chain, Oxalate:formate antiporter
Authors:Shimamura, T, Hirai, T, Yamashita, A.
Deposit date:2022-12-12
Release date:2023-02-15
Last modified:2023-04-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota.
Nat Commun, 14, 2023
8HPK
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BU of 8hpk by Molmil
Crystal structure of the bacterial oxalate transporter OxlT in an oxalate-bound occluded form
Descriptor: Fab fragment Heavy chein, Fab fragment Light chain, OXALATE ION, ...
Authors:Shimamura, T, Hirai, T, Yamashita, A.
Deposit date:2022-12-12
Release date:2023-02-15
Last modified:2023-04-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota.
Nat Commun, 14, 2023

 

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