2W58
 
 | | Crystal Structure of the DnaI | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Tsai, K.L, Lo, Y.H, Sun, Y.J, Hsiao, C.D. | | Deposit date: | 2008-12-08 | | Release date: | 2009-12-22 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular Interplay between the Replicative Helicase Dnac and its Loader Protein Dnai from Geobacillus Kaustophilus.
J.Mol.Biol., 393, 2009
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6XI8
 | | Yeast TFIIK (Kin28/Ccl1/Tfb3) Complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Cyclin CCL1, ... | | Authors: | van Eeuwen, T, Murakami, K, Li, T, Tsai, K.L. | | Deposit date: | 2020-06-19 | | Release date: | 2021-04-28 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Structure of TFIIK for phosphorylation of CTD of RNA polymerase II.
Sci Adv, 7, 2021
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7KPW
 | | Structure of the H-lobe of yeast CKM | | Descriptor: | Mediator of RNA polymerase II transcription subunit 12 | | Authors: | Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2020-11-12 | | Release date: | 2021-01-27 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
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7KPX
 | | Structure of the yeast CKM | | Descriptor: | Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ... | | Authors: | Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2020-11-12 | | Release date: | 2021-01-27 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
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7KPV
 | | Structure of kinase and Central lobes of yeast CKM | | Descriptor: | Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ... | | Authors: | Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2020-11-12 | | Release date: | 2021-01-27 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
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7KUE
 | | CryoEM structure of Yeast TFIIK (Kin28/Ccl1/Tfb3) Complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Cyclin CCL1, ... | | Authors: | van Eeuwen, T, Murakami, K, Li, T, Tsai, K.L. | | Deposit date: | 2020-11-24 | | Release date: | 2021-04-28 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of TFIIK for phosphorylation of CTD of RNA polymerase II.
Sci Adv, 7, 2021
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7UIF
 | | Mediator-PIC Early (Core B) | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | Deposit date: | 2022-03-29 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UIC
 | | Mediator-PIC Early (Tail A) | | Descriptor: | Mediator of RNA polymerase II transcription subunit 14, Mediator of RNA polymerase II transcription subunit 15, Mediator of RNA polymerase II transcription subunit 16, ... | | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | Deposit date: | 2022-03-29 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UI9
 | | Core Mediator-PICearly (Copy A) | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | Deposit date: | 2022-03-28 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UIG
 | | Mediator-PIC Early (Mediator A) | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... | | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | Deposit date: | 2022-03-29 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UIL
 | | Mediator-PIC Early (Tail A/B Dimer) | | Descriptor: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 14, Mediator of RNA polymerase II transcription subunit 15, ... | | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | Deposit date: | 2022-03-29 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UIO
 | | Mediator-PIC Early (Composite Model) | | Descriptor: | ALANINE, ASPARTIC ACID, DNA (37-MER), ... | | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | Deposit date: | 2022-03-29 | | Release date: | 2023-03-01 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UIK
 | | Mediator-PIC Early (Tail A + Upstream DNA & Activator) | | Descriptor: | DNA (37-MER), DNA (38-MER), Mediator of RNA polymerase II transcription subunit 14, ... | | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | Deposit date: | 2022-03-29 | | Release date: | 2023-03-01 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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3RJ1
 | | Architecture of the Mediator Head module | | Descriptor: | Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, Mediator of RNA polymerase II transcription subunit 18, ... | | Authors: | Imasaki, T, Calero, G, Cai, G, Tsai, K.L, Yamada, K, Cardelli, F, Erdjument-Bromage, H, Tempst, P, Berger, I, Kornberg, G.L, Asturias, F.J, Kornberg, R.D, Takagi, Y. | | Deposit date: | 2011-04-14 | | Release date: | 2011-07-27 | | Last modified: | 2017-08-02 | | Method: | X-RAY DIFFRACTION (4.3 Å) | | Cite: | Architecture of the Mediator head module.
Nature, 475, 2011
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2VYE
 | | Crystal Structure of the DnaC-ssDNA complex | | Descriptor: | 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP)-3', REPLICATIVE DNA HELICASE | | Authors: | Lo, Y.H, Tsai, K.L, Sun, Y.J, Hsiao, C.D. | | Deposit date: | 2008-07-23 | | Release date: | 2008-12-30 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | The Crystal Structure of a Replicative Hexameric Helicase Dnac and its Complex with Single-Stranded DNA.
Nucleic Acids Res., 37, 2009
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2VYF
 | | Crystal Structure of the DnaC | | Descriptor: | GOLD ION, REPLICATIVE DNA HELICASE | | Authors: | Lo, Y.H, Tsai, K.L, Sun, Y.J, Hsiao, C.D. | | Deposit date: | 2008-07-23 | | Release date: | 2008-12-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | The Crystal Structure of a Replicative Hexameric Helicase Dnac and its Complex with Single-Stranded DNA.
Nucleic Acids Res., 37, 2009
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6AUI
 | | Human ribonucleotide reductase large subunit (alpha) with dATP and CDP | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. | | Deposit date: | 2017-09-01 | | Release date: | 2018-04-18 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.
Elife, 7, 2018
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5U0S
 | | Cryo-EM structure of the Mediator-RNAPII complex | | Descriptor: | Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... | | Authors: | Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. | | Deposit date: | 2016-11-26 | | Release date: | 2017-03-08 | | Last modified: | 2020-01-01 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Mediator structure and rearrangements required for holoenzyme formation.
Nature, 544, 2017
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5U0P
 | | Cryo-EM structure of the transcriptional Mediator | | Descriptor: | Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... | | Authors: | Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. | | Deposit date: | 2016-11-26 | | Release date: | 2017-03-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Mediator structure and rearrangements required for holoenzyme formation.
Nature, 544, 2017
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4IQ4
 | | Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P21212 form | | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2013-01-10 | | Release date: | 2013-07-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.495 Å) | | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly.
J.Am.Chem.Soc., 135, 2013
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4ITV
 | | Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P212121 form | | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2013-01-18 | | Release date: | 2013-07-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.598 Å) | | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly.
J.Am.Chem.Soc., 135, 2013
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4IVJ
 | | Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, I222 form | | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | | Deposit date: | 2013-01-23 | | Release date: | 2013-07-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (7.351 Å) | | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly.
J.Am.Chem.Soc., 135, 2013
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4QCC
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