Author results

2M4Q
  • Download 2m4q
  • View 2m4q
Molmil generated image of 2m4q
NMR STRUCTURE OF E. COLI RIBOSOMELA DECODING SITE WITH APRAMYCIN
Descriptor:RNA (27-MER), APRAMYCIN
Authors:Puglisi, J.D., Tsai, A., Marshall, R., Viani, E.
Deposit date:2013-02-10
Release date:2013-03-20
Method:SOLUTION NMR
Cite:The impact of aminoglycosides on the dynamics of translation elongation.
Cell Rep, 3, 2013
3J4J
  • Download 3j4j
  • View 3j4j
Molmil generated image of 3j4j
MODEL OF FULL-LENGTH T. THERMOPHILUS TRANSLATION INITIATION FACTOR 2 REFINED AGAINST ITS CRYO-EM DENSITY FROM A 30S INITIATION COMPLEX MAP
Descriptor:Translation initiation factor IF-2
Authors:Simonetti, A., Marzi, S., Billas, I.M.L., Tsai, A., Fabbretti, A., Myasnikov, A., Roblin, P., Vaiana, A.C., Hazemann, I., Eiler, D., Steitz, T.A., Puglisi, J.D., Gualerzi, C.O., Klaholz, B.P.
Deposit date:2013-08-26
Release date:2013-09-25
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
1A40
  • Download 1a40
  • View 1a40
Molmil generated image of 1a40
PHOSPHATE-BINDING PROTEIN WITH ALA 197 REPLACED WITH TRP
Descriptor:PHOSPHATE-BINDING PERIPLASMIC PROTEIN PRECURSOR, PHOSPHATE ION
Authors:Ledivina, P.S., Wang, Z., Tsai, A., Koehl, E., Quiocho, F.A.
Deposit date:1998-02-10
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Dominant role of local dipolar interactions in phosphate binding to a receptor cleft with an electronegative charge surface: equilibrium, kinetic, and crystallographic studies.
Protein Sci., 7, 1998
4NCE
  • Download 4nce
  • View 4nce
Molmil generated image of 4nce
INFLUENZA POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO 7-METHYL-GTP
Descriptor:Polymerase basic protein 2, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid
Authors:Jacobs, M.D.
Deposit date:2013-10-24
Release date:2014-07-30
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
4NCM
  • Download 4ncm
  • View 4ncm
Molmil generated image of 4ncm
INFLUENZA POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO A SMALL-MOLECULE INHIBITOR
Descriptor:Polymerase basic protein 2, N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N,N-dimethyl-L-alaninamide
Authors:Jacobs, M.D.
Deposit date:2013-10-24
Release date:2014-07-30
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
4P1U
  • Download 4p1u
  • View 4p1u
Molmil generated image of 4p1u
INFLUENZA A (FLU) VIRUS POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO VX787, AN AZAINDOLE INHIBITOR
Descriptor:Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid
Authors:Jacobs, M.D.
Deposit date:2014-02-27
Release date:2014-07-30
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
5BUH
  • Download 5buh
  • View 5buh
Molmil generated image of 5buh
INFLUENZA PB2 BOUND TO A HYDROXYMETHYL AZAINDOLE INHIBITOR
Descriptor:Polymerase basic protein 2, N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide
Authors:Jacobs, M.D.
Deposit date:2015-06-03
Release date:2016-06-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.
ACS Med Chem Lett, 8, 2017
5F79
  • Download 5f79
  • View 5f79
Molmil generated image of 5f79
INFLUENZA PB2 BOUND TO AN AZAINDOLE INHIBITOR
Descriptor:Polymerase basic protein 2, N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide
Authors:Jacobs, M.D.
Deposit date:2015-12-07
Release date:2016-12-07
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.
ACS Med Chem Lett, 8, 2017
5JUN
  • Download 5jun
  • View 5jun
Molmil generated image of 5jun
PB2 BOUND TO AN AZAINDOLE INHIBITOR
Descriptor:Polymerase basic protein 2, (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-3-(1-methylcyclobutyl)propanoic acid
Authors:Jacobs, M.D.
Deposit date:2016-05-10
Release date:2017-05-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett, 8, 2017
5JUR
  • Download 5jur
  • View 5jur
Molmil generated image of 5jur
PB2 BOUND TO AN AZAINDOLE INHIBITOR
Descriptor:Polymerase basic protein 2, (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-4,4-dimethyl-pentanoic acid
Authors:Jacobs, M.D.
Deposit date:2016-05-10
Release date:2017-03-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett, 8, 2017
6ASV
  • Download 6asv
  • View 6asv
Molmil generated image of 6asv
E. COLI PRPP SYNTHETASE
Descriptor:Ribose-phosphate pyrophosphokinase, PHOSPHATE ION, CHLORIDE ION
Authors:French, J.B., Zhou, W.
Deposit date:2017-08-25
Release date:2019-01-23
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structure of E. coli PRPP synthetase.
BMC Struct. Biol., 19, 2019