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2XK9
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STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 (CHK2) IN COMPLEX WITH INHIBITOR PV1533
分子名称:CHECKPOINT KINASE 2, N-{4-[(1E)-N-(N-hydroxycarbamimidoyl)ethanehydrazonoyl]phenyl}-7-nitro-1H-indole-2-carboxamide
著者Lountos, G.T., Jobson, A.G., Tropea, J.E., Self, C., Shoemaker, R.H., Pommier, Y., Waugh, D.S.
登録日2010-07-07
公開日2011-07-20
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176, 2011
2YIQ
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STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 IN COMPLEX WITH INHIBITOR PV1322
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK2, (E)-5-(1-(2-CARBAMIMIDOYLHYDRAZONO)ETHYL)-N-(1H-INDOL-6-YL)-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION
著者Lountos, G.T., Jobson, A.G., Tropea, J.E., Self, C., Zhang, G., Pommier, Y., Shoemaker, R.H., Waugh, D.S.
登録日2011-05-16
公開日2011-09-07
最終更新日2011-10-26
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
2YIR
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STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 IN COMPLEX WITH INHIBITOR PV1352
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK2, (E)-N-(5-(2-CARBAMIMIDOYLHYDRAZONO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION
著者Lountos, G.T., Jobson, A.G., Tropea, J.E., Self, C., Zhang, G., Pommier, Y., Shoemaker, R.H., Waugh, D.S.
登録日2011-05-16
公開日2011-09-07
最終更新日2011-10-26
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
2YIT
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STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 IN COMPLEX WITH PV1162, A NOVEL INHIBITOR
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK2, N-{4-[(1E)-N-carbamimidoylbutanehydrazonoyl]phenyl}-5-methoxy-1H-indole-2-carboxamide, NITRATE ION
著者Lountos, G.T., Jobson, A.G., Tropea, J.E., Self, C., Zhang, G., Pommier, Y., Shoemaker, R.H., Waugh, D.S.
登録日2011-05-16
公開日2011-09-07
最終更新日2011-10-26
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
1HY5
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF YOPE-YERSINIA PESTIS GAP EFFECTOR PROTEIN.
分子名称:YERSINIA PESTIS VIRULENCE PROTEIN YOPE
著者Evdokimov, A.G., Tropea, J.E., Routzahn, K.M., Waugh, D.S.
登録日2001-01-18
公開日2002-02-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of the Yersinia pestis GTPase activator YopE.
Protein Sci., 11, 2002
1K6Z
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CRYSTAL STRUCTURE OF THE YERSINIA SECRETION CHAPERONE SYCE
分子名称:Type III secretion chaperone SycE, IMIDAZOLE
著者Evdokimov, A.G., Tropea, J.E., Routzahn, K.M., Waugh, D.S.
登録日2001-10-17
公開日2001-10-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Three-dimensional structure of the type III secretion chaperone SycE from Yersinia pestis.
Acta Crystallogr.,Sect.D, 58, 2002
1LVB
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CATALYTICALLY INACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH SUBSTRATE
分子名称:CATALYTIC DOMAIN OF THE NUCLEAR INCLUSION PROTEIN A (NIA), OLIGOPEPTIDE SUBSTRATE FOR THE PROTEASE, GLYCEROL
著者Phan, J., Zdanov, A., Evdokimov, A.G., Tropea, J.E., Peters III, H.K., Kapust, R.B., Li, M., Wlodawer, A., Waugh, D.S.
登録日2002-05-28
公開日2002-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the substrate specificity of tobacco etch virus protease.
J.Biol.Chem., 277, 2002
1LVM
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CATALYTICALLY ACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH PRODUCT
分子名称:CATALYTIC DOMAIN OF THE NUCLEAR INCLUSION PROTEIN A (NIA), OLIGOPEPTIDE SUBSTRATE FOR THE PROTEASE
著者Phan, J., Zdanov, A., Evdokimov, A.G., Tropea, J.E., Peters III, H.K., Kapust, R.B., Li, M., Wlodawer, A., Waugh, D.S.
登録日2002-05-28
公開日2002-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for the substrate specificity of tobacco etch virus protease.
J.Biol.Chem., 277, 2002
1ORJ
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FLAGELLAR EXPORT CHAPERONE
分子名称:flagellar protein FliS
著者Evdokimov, A.G., Phan, J., Tropea, J.E., Routzahn, K.M., Peters III, H.K., Pokross, M., Waugh, D.S.
登録日2003-03-13
公開日2003-09-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Similar modes of polypeptide recognition by export chaperones in flagellar biosynthesis and type III secretion
Nat.Struct.Biol., 10, 2003
1ORY
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FLAGELLAR EXPORT CHAPERONE IN COMPLEX WITH ITS COGNATE BINDING PARTNER
分子名称:flagellar protein FliS, Flagellin, PHOSPHATE ION
著者Evdokimov, A.G., Phan, J., Tropea, J.E., Routzahn, K.M., Peters III, H.K., Pokross, M., Waugh, D.S.
登録日2003-03-17
公開日2003-09-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Similar modes of polypeptide recognition by export chaperones in flagellar biosynthesis and type III secretion
Nat.Struct.Biol., 10, 2003
1QZ0
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CRYSTAL STRUCTURE OF THE YERSINIA PESTIS PHOSPHATASE YOPH IN COMPLEX WITH A PHOSPHOTYROSYL MIMETIC-CONTAINING HEXAPEPTIDE
分子名称:Protein-tyrosine phosphatase yopH, ASP-ALA-ASP-GLU-FTY-LEU-NH2
著者Phan, J., Lee, K., Cherry, S., Tropea, J.E., Burke Jr, T.R., Waugh, D.S.
登録日2003-09-15
公開日2003-11-25
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献High-Resolution Structure of the Yersinia pestis Protein Tyrosine Phosphatase YopH in Complex with a Phosphotyrosyl Mimetic-Containing Hexapeptide
Biochemistry, 42, 2003
1QZM
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ALPHA-DOMAIN OF ATPASE
分子名称:ATP-dependent protease La
著者Botos, I., Melnikov, E.E., Cherry, S., Khalatova, A.G., Rasulova, F.S., Tropea, J.E., Maurizi, M.R., Rotanova, T.V., Gustchina, A., Wlodawer, A.
登録日2003-09-17
公開日2004-05-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution.
J.Struct.Biol., 146
1RR9
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CATALYTIC DOMAIN OF E.COLI LON PROTEASE
分子名称:ATP-dependent protease La, SULFATE ION
著者Botos, I., Melnikov, E.E., Cherry, S., Tropea, J.E., Khalatova, A.G., Dauter, Z., Maurizi, M.R., Rotanova, T.V., Wlodawer, A., Gustchina, A.
登録日2003-12-08
公開日2003-12-23
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site
J.Biol.Chem., 279, 2004
1RRE
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CRYSTAL STRUCTURE OF E.COLI LON PROTEOLYTIC DOMAIN
分子名称:ATP-dependent protease La, SULFATE ION
著者Botos, I., Melnikov, E.E., Cherry, S., Tropea, J.E., Khalatova, A.G., Rasulova, F., Dauter, Z., Maurizi, M.R., Rotanova, T.V., Wlodawer, A., Gustchina, A.
登録日2003-12-08
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site
J.Biol.Chem., 279, 2004
1TTW
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CRYSTAL STRUCTURE OF THE YERSINIA PESTIS TYPE III SECRETION CHAPERONE SYCH IN COMPLEX WITH A STABLE FRAGMENT OF YSCM2
分子名称:secretion chaperone, YscM2
著者Phan, J., Tropea, J.E., Waugh, D.S.
登録日2004-06-23
公開日2004-08-31
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structure of the Yersinia pestis type III secretion chaperone SycH in complex with a stable fragment of YscM2.
Acta Crystallogr.,Sect.D, 60, 2004
1XKP
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CRYSTAL STRUCTURE OF THE VIRULENCE FACTOR YOPN IN COMPLEX WITH ITS HETERODIMERIC CHAPERONE SYCN-YSCB
分子名称:putative membrane-bound Yop targeting protein YopN, Chaperone protein sycN, Chaperone protein yscB
著者Schubot, F.D., Jackson, M.W., Penrose, K.J., Cherry, S., Tropea, J.E., Plano, G.V., Waugh, D.S.
登録日2004-09-29
公開日2005-03-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis.
J.Mol.Biol., 346, 2005
1XL3
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COMPLEX STRUCTURE OF Y.PESTIS VIRULENCE FACTORS YOPN AND TYEA
分子名称:Secretion control protein, protein type A
著者Schubot, F.D., Jackson, M.W., Penrose, K.J., Cherry, S., Tropea, J.E., Plano, G.V., Waugh, D.S.
登録日2004-09-30
公開日2005-03-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis.
J.Mol.Biol., 346, 2005
1YYK
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CRYSTAL STRUCTURE OF RNASE III FROM AQUIFEX AEOLICUS COMPLEXED WITH DOUBLE-STRANDED RNA AT 2.5-ANGSTROM RESOLUTION
分子名称:5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3', Ribonuclease III, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Gan, J., Tropea, J.E., Austin, B.P., Court, D.L., Waugh, D.S., Ji, X.
登録日2005-02-25
公開日2005-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Intermediate states of ribonuclease III in complex with double-stranded RNA
Structure, 13, 2005
1YYO
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CRYSTAL STRUCTURE OF RNASE III MUTANT E110K FROM AQUIFEX AEOLICUS COMPLEXED WITH DOUBLE-STRANDED RNA AT 2.9-ANGSTROM RESOLUTION
分子名称:5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3', Ribonuclease III, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Gan, J., Tropea, J.E., Austin, B.P., Court, D.L., Waugh, D.S., Ji, X.
登録日2005-02-25
公開日2005-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Intermediate states of ribonuclease III in complex with double-stranded RNA
Structure, 13, 2005
1YYW
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CRYSTAL STRUCTURE OF RNASE III FROM AQUIFEX AEOLICUS COMPLEXED WITH DOUBLE STRANDED RNA AT 2.8-ANGSTROM RESOLUTION
分子名称:5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3', Ribonuclease III
著者Gan, J., Tropea, J.E., Austin, B.P., Court, D.L., Waugh, D.S., Ji, X.
登録日2005-02-25
公開日2005-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Intermediate states of ribonuclease III in complex with double-stranded RNA
Structure, 13, 2005
1YZ9
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CRYSTAL STRUCTURE OF RNASE III MUTANT E110Q FROM AQUIFEX AEOLICUS COMPLEXED WITH DOUBLE STRANDED RNA AT 2.1-ANGSTROM RESOLUTION
分子名称:5'-R(*CP*GP*AP*AP*CP*UP*UP*CP*GP*CP*G)-3', Ribonuclease III, SULFATE ION
著者Gan, J., Tropea, J.E., Austin, B.P., Court, D.L., Waugh, D.S., Ji, X.
登録日2005-02-28
公開日2005-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Intermediate states of ribonuclease III in complex with double-stranded RNA
Structure, 13, 2005
1Z0B
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CRYSTAL STRUCTURE OF A. FULGIDUS LON PROTEOLYTIC DOMAIN E506A MUTANT
分子名称:Putative protease La homolog type, CALCIUM ION
著者Botos, I., Melnikov, E.E., Cherry, S., Kozlov, S., Makhovskaya, O.V., Tropea, J.E., Gustchina, A., Rotanova, T.V., Wlodawer, A.
登録日2005-03-01
公開日2005-08-02
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Atomic-resolution Crystal Structure of the Proteolytic Domain of Archaeoglobus fulgidus Lon Reveals the Conformational Variability in the Active Sites of Lon Proteases
J.Mol.Biol., 351, 2005
1Z0C
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CRYSTAL STRUCTURE OF A. FULGIDUS LON PROTEOLYTIC DOMAIN D508A MUTANT
分子名称:Putative protease La homolog type
著者Botos, I., Melnikov, E.E., Cherry, S., Kozlov, S., Makhovskaya, O.V., Tropea, J.E., Gustchina, A., Rotanova, T.V., Wlodawer, A.
登録日2005-03-01
公開日2005-08-02
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Atomic-resolution Crystal Structure of the Proteolytic Domain of Archaeoglobus fulgidus Lon Reveals the Conformational Variability in the Active Sites of Lon Proteases
J.Mol.Biol., 351, 2005
1Z0E
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CRYSTAL STRUCTURE OF A. FULGIDUS LON PROTEOLYTIC DOMAIN
分子名称:Putative protease La homolog type
著者Botos, I., Melnikov, E.E., Cherry, S., Kozlov, S., Makhovskaya, O.V., Tropea, J.E., Gustchina, A., Rotanova, T.V., Wlodawer, A.
登録日2005-03-01
公開日2005-08-02
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Atomic-resolution Crystal Structure of the Proteolytic Domain of Archaeoglobus fulgidus Lon Reveals the Conformational Variability in the Active Sites of Lon Proteases
J.Mol.Biol., 351, 2005
1Z0G
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CRYSTAL STRUCTURE OF A. FULGIDUS LON PROTEOLYTIC DOMAIN
分子名称:Putative protease La homolog type
著者Botos, I., Melnikov, E.E., Cherry, S., Kozlov, S., Makhovskaya, O.V., Tropea, J.E., Gustchina, A., Rotanova, T.V., Wlodawer, A.
登録日2005-03-01
公開日2005-08-02
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Atomic-resolution Crystal Structure of the Proteolytic Domain of Archaeoglobus fulgidus Lon Reveals the Conformational Variability in the Active Sites of Lon Proteases
J.Mol.Biol., 351, 2005