Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2Z4O
DownloadVisualize
BU of 2z4o by Molmil
Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-98065
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, ACETATE ION, CHLORIDE ION, ...
Authors:Wang, Y.F, Tie, Y, Boross, P.I, Tozser, J, Ghosh, A.K, Harrison, R.W, Weber, I.T.
Deposit date:2007-06-20
Release date:2008-04-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007
1SDU
DownloadVisualize
BU of 1sdu by Molmil
Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
Descriptor: ACETATE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, SULFATE ION, ...
Authors:Mahalingam, B, Wang, Y.-F, Boross, P.I, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:2004-02-14
Release date:2004-05-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
Eur.J.Biochem., 271, 2004
3MMG
DownloadVisualize
BU of 3mmg by Molmil
Crystal structure of tobacco vein mottling virus protease
Descriptor: FORMIC ACID, Nuclear inclusion protein A, Nuclear inclusion protein B fragment
Authors:Ping, S, Austin, B.P, Tozser, J, Waugh, D.S.
Deposit date:2010-04-19
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural determinants of tobacco vein mottling virus protease substrate specificity.
Protein Sci., 19, 2010
1SDV
DownloadVisualize
BU of 1sdv by Molmil
Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
Descriptor: CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, protease RETROPEPSIN
Authors:Mahalingam, B, Wang, Y.-F, Boross, P.I, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:2004-02-14
Release date:2004-05-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
Eur.J.Biochem., 271, 2004
1SDT
DownloadVisualize
BU of 1sdt by Molmil
Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
Descriptor: CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, protease RETROPEPSIN
Authors:Mahalingam, B, Wang, Y.-F, Boross, P.I, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:2004-02-14
Release date:2004-05-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
Eur.J.Biochem., 271, 2004
2H5J
DownloadVisualize
BU of 2h5j by Molmil
Crystal strusture of caspase-3 with inhibitor Ac-DMQD-Cho
Descriptor: Ac-DMQD-Cho, caspase-3, p12 subunit, ...
Authors:Fang, B, Boross, P.I, Tozser, J, Weber, I.T.
Deposit date:2006-05-26
Release date:2006-09-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
2H5I
DownloadVisualize
BU of 2h5i by Molmil
Crystal structure of caspase-3 with inhibitor Ac-DEVD-Cho
Descriptor: Ac-DEV(ASJ), caspase-3, p12 subunit, ...
Authors:Fang, B, Boross, P.I, Tozser, J, Weber, I.T.
Deposit date:2006-05-26
Release date:2006-09-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
2H65
DownloadVisualize
BU of 2h65 by Molmil
Crystal strusture of caspase-3 with inhibitor Ac-VDVAD-Cho
Descriptor: Ac-VDVAD-Cho, caspase-3, p12 subunit, ...
Authors:Fang, B, Boross, P.I, Tozser, J, Weber, I.T.
Deposit date:2006-05-30
Release date:2006-09-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
1K2C
DownloadVisualize
BU of 1k2c by Molmil
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Descriptor: N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN
Authors:Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, W Harrison, R, Weber, I.T.
Deposit date:2001-09-26
Release date:2002-07-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1K1T
DownloadVisualize
BU of 1k1t by Molmil
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Descriptor: N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN, SULFATE ION
Authors:Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2001-09-25
Release date:2002-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1K2B
DownloadVisualize
BU of 1k2b by Molmil
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Descriptor: N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN
Authors:Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, W Harrison, R, Weber, I.T.
Deposit date:2001-09-26
Release date:2002-07-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1K1U
DownloadVisualize
BU of 1k1u by Molmil
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Descriptor: N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN
Authors:Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, W Harrison, R, Weber, I.T.
Deposit date:2001-09-25
Release date:2002-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
2AOJ
DownloadVisualize
BU of 2aoj by Molmil
Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR
Descriptor: ACETIC ACID, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOC
DownloadVisualize
BU of 2aoc by Molmil
Crystal structure analysis of HIV-1 protease mutant I84V with a substrate analog P2-NC
Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOG
DownloadVisualize
BU of 2aog by Molmil
Crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog P2-NC
Descriptor: ACETIC ACID, GLYCEROL, HIV-1 PROTEASE (RETROPEPSIN), ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOD
DownloadVisualize
BU of 2aod by Molmil
Crystal structure analysis of HIV-1 protease with a substrate analog P2-NC
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, HIV-1 PROTEASE, ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOE
DownloadVisualize
BU of 2aoe by Molmil
crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2
Descriptor: ACETIC ACID, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOF
DownloadVisualize
BU of 2aof by Molmil
Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P1-P6
Descriptor: ACETIC ACID, CHLORIDE ION, PEPTIDE INHIBITOR, ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOI
DownloadVisualize
BU of 2aoi by Molmil
Crystal structure analysis of HIV-1 protease with a substrate analog P1-P6
Descriptor: PEPTIDE INHIBITOR, POL POLYPROTEIN, SULFATE ION
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2AOH
DownloadVisualize
BU of 2aoh by Molmil
Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR
Descriptor: CHLORIDE ION, PEPTIDE INHIBITOR, POL POLYPROTEIN, ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2005-08-12
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
2NNP
DownloadVisualize
BU of 2nnp by Molmil
Crystal structure analysis of HIV-1 protease mutant I84V with a inhibitor saquinavir
Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ACETIC ACID, GLYCEROL, ...
Authors:Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2006-10-24
Release date:2007-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.
Proteins, 67, 2007
2NMZ
DownloadVisualize
BU of 2nmz by Molmil
Crystal structure analysis of HIV-1 protease mutant V82A with a inhibitor saquinavir
Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, PROTEASE, SULFATE ION
Authors:Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2006-10-23
Release date:2007-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.
Proteins, 67, 2007
2NNK
DownloadVisualize
BU of 2nnk by Molmil
Crystal structure analysis of HIV-1 protease mutant I84V with a inhibitor saquinavir
Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ACETIC ACID, CHLORIDE ION, ...
Authors:Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2006-10-24
Release date:2007-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.
Proteins, 67, 2007
2NMY
DownloadVisualize
BU of 2nmy by Molmil
Crystal structure analysis of HIV-1 protease mutant V82A with a inhibitor saquinavir
Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, PROTEASE, ...
Authors:Tie, Y, Kovalevsky, A.Y, Boross, P, Wang, Y.F, Ghosh, A.K, Tozser, J, Harrison, R.W, Weber, I.T.
Deposit date:2006-10-23
Release date:2007-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.
Proteins, 67, 2007
2QCI
DownloadVisualize
BU of 2qci by Molmil
HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, ACETATE ION, CHLORIDE ION, ...
Authors:Wang, Y.F, Tie, Y, Boross, P.I, Tozser, J, Ghosh, A.K, Harrison, R.W, Weber, I.T.
Deposit date:2007-06-19
Release date:2008-04-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
J.Med.Chem., 50, 2007

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon