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1JGT
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CRYSTAL STRUCTURE OF BETA-LACTAM SYNTHETASE
Descriptor:BETA-LACTAM SYNTHETASE, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Miller, M.T., Bachmann, B.O., Townsend, C.A., Rosenzweig, A.C.
Deposit date:2001-06-26
Release date:2001-12-28
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine.
Nat.Struct.Biol., 8, 2001
1M1Z
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BETA-LACTAM SYNTHETASE APO ENZYME
Descriptor:BETA-LACTAM SYNTHETASE
Authors:Miller, M.T., Bachmann, B.O., Townsend, C.A., Rosenzweig, A.C.
Deposit date:2002-06-20
Release date:2002-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
1MB9
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BETA-LACTAM SYNTHETASE COMPLEXED WITH ATP
Descriptor:BETA-LACTAM SYNTHETASE, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Miller, M.T., Bachmann, B.O., Townsend, C.A., Rosenzweig, A.C.
Deposit date:2002-08-02
Release date:2002-10-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
1MBZ
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BETA-LACTAM SYNTHETASE WITH TRAPPED INTERMEDIATE
Descriptor:BETA-LACTAM SYNTHETASE, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Miller, M.T., Bachmann, B.O., Townsend, C.A., Rosenzweig, A.C.
Deposit date:2002-08-04
Release date:2002-10-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
1MC1
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BETA-LACTAM SYNTHETASE WITH PRODUCT (DGPC), AMP AND PPI
Descriptor:BETA-LACTAM SYNTHETASE, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Miller, M.T., Bachmann, B.O., Townsend, C.A., Rosenzweig, A.C.
Deposit date:2002-08-04
Release date:2002-10-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
1Q15
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CARBAPENAM SYNTHETASE
Descriptor:CarA
Authors:Miller, M.T., Gerratana, B., Stapon, A., Townsend, C.A., Rosenzweig, A.C.
Deposit date:2003-07-18
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Carbapenam Synthetase (CarA)
J.Biol.Chem., 278, 2003
1Q19
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CARBAPENAM SYNTHETASE
Descriptor:CarA, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Miller, M.T., Gerratana, B., Stapon, A., Townsend, C.A., Rosenzweig, A.C.
Deposit date:2003-07-18
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Carbapenam Synthetase (CarA)
J.Biol.Chem., 278, 2003
4IHD
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CRYSTAL STRUCTURE OF UNCLEAVED THNT T282C, DERIVATIZED AT THE ACTIVE SITE WITH ETHG
Descriptor:ThnT protein, ETHYL MERCURY ION
Authors:Buller, A.R., Schildbach, J.F., Townsend, C.A.
Deposit date:2012-12-18
Release date:2014-08-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT.
Biochemistry, 53, 2014
4IHE
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CRYSTAL STRUCTURE OF UNCLEAVED THNT T282A
Descriptor:ThnT protein
Authors:Buller, A.R., Schildbach, J.F., Townsend, C.A.
Deposit date:2012-12-18
Release date:2014-08-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT.
Biochemistry, 53, 2014
5KBZ
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STRUCTURE OF THE PKSA PRODUCT TEMPLATE DOMAIN IN COMPLEX WITH A PHOSPHOPANTETHEINE MIMETIC
Descriptor:Noranthrone synthase, (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate
Authors:Tsai, S.C., Burkart, M.D., Townsend, C.A., Barajas, J.F., Shakya, G., Topper, C.L., Moreno, G., Jackson, D.R., Rivera, H., La Clair, J.J., Vagstad, A.
Deposit date:2016-06-03
Release date:2017-05-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5MPT
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STRUCTURE OF THE CITRININ POLYKETIDE SYNTHASE CMET DOMAIN
Descriptor:Citrinin polyketide synthase, S-ADENOSYL-L-HOMOCYSTEINE, 1,2-ETHANEDIOL
Authors:Herbst, D.A., Storm, P.A., Townsend, C.A., Maier, T.
Deposit date:2016-12-19
Release date:2017-02-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.648 Å)
Cite:Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin.
Cell Chem Biol, 24, 2017
6FIJ
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STRUCTURE OF THE LOADING/CONDENSING REGION (SAT-KS-MAT) OF THE CERCOSPORIN FUNGAL NON-REDUCING POLYKETIDE SYNTHASE (NR-PKS) CTB1
Descriptor:Polyketide synthase, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Herbst, D.A., Jakob, R.P., Townsend, C.A., Maier, T.
Deposit date:2018-01-18
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
6FIK
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ACP2 CROSSLINKED TO THE KS OF THE LOADING/CONDENSING REGION OF THE CTB1 PKS
Descriptor:Polyketide synthase
Authors:Herbst, D.A., Huitt-Roehl, C.R., Jakob, R.P., Townsend, C.A., Maier, T.
Deposit date:2018-01-18
Release date:2018-03-21
Last modified:2018-04-25
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
4Z7A
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF A NON-FUNCTIONALLY REDUNDANT M. TUBERCULOSIS (3,3) L,D-TRANSPEPTIDASE, LDTMT5.
Descriptor:Mycobacterium tuberculosis (3,3)L,D-Transpeptidase type 5, PHOSPHATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Basta, L., Ghosh, A., Pan, Y., Jakoncic, J., Lloyd, E., Townsend, G., Lamichhane, G., Bianchet, M.A.
Deposit date:2015-04-06
Release date:2015-09-02
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.
J.Biol.Chem., 290, 2015
3HRQ
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THE PRODUCT TEMPLATE DOMAIN FROM PKSA WITH PALMITATE BOUND
Descriptor:Aflatoxin biosynthesis polyketide synthase, PALMITIC ACID
Authors:Korman, T.P., Tsai, S.C.
Deposit date:2009-06-09
Release date:2009-10-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
Nature, 461, 2009
3HRR
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THE PRODUCT TEMPLATE DOMAIN FROM PKSA WITH HARRIS COMPOUND BOUND
Descriptor:Aflatoxin biosynthesis polyketide synthase, 1-(3-acetyl-4,5-dihydroxy-7-methoxynaphthalen-2-yl)propan-2-one
Authors:Korman, T.P., Tsai, S.C.
Deposit date:2009-06-09
Release date:2009-10-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
Nature, 461, 2009
3ILS
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THE THIOESTERASE DOMAIN FROM PKSA
Descriptor:Aflatoxin biosynthesis polyketide synthase
Authors:Korman, T.P.
Deposit date:2009-08-07
Release date:2010-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.
Proc.Natl.Acad.Sci.USA, 107, 2010
3S3U
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CRYSTAL STRUCTURE OF UNCLEAVED THNT T282C
Descriptor:cysteine transferase
Authors:Schildbach, J.F., Wright, N.T., Buller, A.R.
Deposit date:2011-05-18
Release date:2012-02-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TM1
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CRYSTAL STRUCTURE OF MATURE THNT, A PANTETHEINE HYDROLASE
Descriptor:cysteine transferase, GLYCEROL
Authors:Schildbach, J.F., Wright, N.T., Buller, A.R.
Deposit date:2011-08-30
Release date:2012-07-04
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis.
J.Mol.Biol., 422, 2012
3TM2
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CRYSTAL STRUCTURE OF MATURE THNT WITH A COVALENTLY BOUND PRODUCT MIMIC
Descriptor:cysteine transferase, (2R)-N-(4-chloro-3-oxobutyl)-2,4-dihydroxy-3,3-dimethylbutanamide
Authors:Schildbach, J.F., Wright, N.T., Buller, A.R.
Deposit date:2011-08-30
Release date:2012-07-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis.
J.Mol.Biol., 422, 2012
4ZFQ
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STRUCTURE OF M. TUBERCULOSIS (3,3) L,D-TRANSPEPTIDASE, LDTMT5. (MEROPENEN-ADDUCT FORM)
Descriptor:L,D-transpeptidase 5, DI(HYDROXYETHYL)ETHER, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid
Authors:Basta, L., Ghosh, A., Lamichhane, G., Bianchet, M.A.
Deposit date:2015-04-21
Release date:2015-09-02
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.
J.Biol.Chem., 290, 2015
5D7H
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X-RAY CRYSTAL STRUCTURE OF L,D TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:L,D-transpeptidase 2, SULFATE ION, GLYCEROL
Authors:Saavedra, H., Basta, L.A., Lamichhane, G., Bianchet, M.A.
Deposit date:2015-08-13
Release date:2016-09-28
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
BMC Biochem., 18, 2017
5DC2
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X-RAY CRYSTAL STRUCTURE OF A ENZYMATICALLY DEGRADED BIAPENEM-ADDUCT OF L,D-TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:L,D-transpeptidase 2, (4S)-4-methyl-2,5,7-trioxoheptanoic acid, SULFATE ION, ...
Authors:Pan, Y., Basta, L., Lamichhane, G., Bianchet, M.A.
Deposit date:2015-08-23
Release date:2016-10-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.182 Å)
Cite:Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
BMC Biochem., 18, 2017
5DCC
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X-RAY CRYSTAL STRUCTURE OF A TEBIPENEM ADDUCT OF L,D TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:L,D-transpeptidase 2, (4S)-4-methyl-2,5,7-trioxoheptanoic acid, SULFATE ION, ...
Authors:Pan, Y., Basta, L., Lamichhane, G., Bianchet, M.A.
Deposit date:2015-08-23
Release date:2016-09-28
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.451 Å)
Cite:Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
BMC Biochem., 18, 2017
5DU7
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CRYSTAL STRUCTURE OF LDTMT2 AT 1.79 ANGSTROM RESOLUTION
Descriptor:L,D-transpeptidase 2
Authors:Kumar, P., Lamichhane, G.
Deposit date:2015-09-18
Release date:2016-09-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Non-classical transpeptidases yield insight into new antibacterials.
Nat. Chem. Biol., 13, 2017
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