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1L6X
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BU of 1l6x by Molmil
FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B-DOMAIN FROM PROTEIN A CALLED Z34C
Descriptor: IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN CONSTANT REGION, Minimized B-domain of Protein A Z34C, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Idusogie, E.E, Presta, L.G, Santoro-Gazzano, H, Totpal, K, Wong, P.Y, Ultsch, M, Meng, Y.G, Mullkerrin, M.G.
Deposit date:2002-03-14
Release date:2002-04-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc.
J.Immunol., 164, 2000
1OQX
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BU of 1oqx by Molmil
G-2 glycovariant of human IgG Fc bound to minimized version of Protein A called Z34C
Descriptor: Protein A Z34C, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Raju, T.S, Mulkerrin, M.G, Parker, M, De Vos, A.M, Gazzano-Santoro, H, Totpal, K, Ultsch, M.H.
Deposit date:2003-03-11
Release date:2003-03-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Impact of Fc Glycans on The Effector Functions Vary with the Antibody mechanism of Action
To be Published
1OQO
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BU of 1oqo by Molmil
Complex between G0 version of an Fc bound to a minimized version of Protein A called Mini-Z
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Minimized version of Protein A (Z34C), ...
Authors:Raju, T.S, Mulkerrin, M.G, Parker, M, De Vos, A.M, Gazzano-Santoro, H, Totpal, K, Ultsch, M.H.
Deposit date:2003-03-10
Release date:2003-03-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Impact of Fc Glycans on The Effector Functions Vary with the Antibody mechanism of Action
To be Published
6URC
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BU of 6urc by Molmil
Crystal structure of IRE1a in complex with compound 18
Descriptor: 2-chloro-N-(6-methyl-5-{[3-(2-{[(3S)-piperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}naphthalen-1-yl)benzene-1-sulfonamide, GLYCEROL, Serine/threonine-protein kinase/endoribonuclease IRE1
Authors:Wallweber, H.H, Wang, W.
Deposit date:2019-10-23
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Disruption of IRE1 alpha through its kinase domain attenuates multiple myeloma.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1DG6
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BU of 1dg6 by Molmil
CRYSTAL STRUCTURE OF APO2L/TRAIL
Descriptor: APO2L/TNF-RELATED APOPOTIS INDUCING LIGAND (TRAIL), CHLORIDE ION, ZINC ION
Authors:Hymowitz, S.G, O'ConnelL, M.P, Ultsch, M.H, de Vos, A.M, Kelley, R.F.
Deposit date:1999-11-23
Release date:2000-01-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Biochemistry, 39, 2000
7S4G
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BU of 7s4g by Molmil
Fab fragment bound to the Cter peptide of Ly6G6D
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Lymphocyte antigen 6 complex locus protein G6d, ...
Authors:Rouge, L, Lupardus, P.
Deposit date:2021-09-08
Release date:2022-04-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
Mol.Cancer Ther., 21, 2022
3GRW
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BU of 3grw by Molmil
FGFR3 in complex with a Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ...
Authors:Wiesmann, C.
Deposit date:2009-03-26
Release date:2009-05-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
J.Clin.Invest., 119, 2009
4OD2
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BU of 4od2 by Molmil
Crystal structure of the Fab fragment of an anti-DR5 antibody bound to DR5
Descriptor: Fab fragment of drozitumab, heavy chain, light chain, ...
Authors:Hymowitz, S.G, Compaan, D.
Deposit date:2014-01-09
Release date:2014-02-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5.
Cell Death Differ., 15, 2008
2H9G
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BU of 2h9g by Molmil
Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5)
Descriptor: Fab BdF1, heavy chain, light chain, ...
Authors:Hymowitz, S.G, Compaan, D.M.
Deposit date:2006-06-09
Release date:2006-08-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists.
J.Mol.Biol., 361, 2006
3P11
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BU of 3p11 by Molmil
anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab DL11 heavy chain, ...
Authors:Eigenbrot, C, Shia, S.
Deposit date:2010-09-29
Release date:2011-10-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
3P0Y
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BU of 3p0y by Molmil
anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
Authors:Eigenbrot, C, Shia, S.
Deposit date:2010-09-29
Release date:2011-10-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
3P0V
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BU of 3p0v by Molmil
anti-EGFR/HER3 Fab DL11 alone
Descriptor: CALCIUM ION, Fab DL11 heavy chain, Fab DL11 light chain
Authors:Eigenbrot, C, Shia, S.
Deposit date:2010-09-29
Release date:2011-10-19
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
5U52
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BU of 5u52 by Molmil
2 helix minimized version of the B-domain from Protein A (Z34C0 bound to IgG1 Fc (monoclinic form)
Descriptor: IGG1 FC, Mini Z domain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Ultsch, M.H, Eigenbrot, C.
Deposit date:2016-12-06
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.942 Å)
Cite:3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix.
Protein Eng. Des. Sel., 30, 2017

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