Author results

5C1Z
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PARKIN (UBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, SULFATE ION, ...
Authors:kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C23
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PARKIN (S65DUBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, GLYCEROL, ...
Authors:Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5N2W
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WT-PARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5N38
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S65DPARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, DI(HYDROXYETHYL)ETHER, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
4S1Z
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CRYSTAL STRUCTURE OF TRABID NZF1 IN COMPLEX WITH K29 LINKED DI-UBIQUITIN
Descriptor:Ubiquitin, Ubiquitin thioesterase ZRANB1, ZINC ION
Authors:Kristariyanto, Y.A., Abdul Rehman, S.A., Campbell, D.G., Morrice, N.A., Johnson, C., Toth, R., Kulathu, Y.
Deposit date:2015-01-16
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Mol.Cell, 58, 2015
4S22
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CRYSTAL STRUCTURE OF K29 LINKED DI-UBIQUITIN
Descriptor:Ubiquitin, IODIDE ION, 1,2-ETHANEDIOL, ...
Authors:Kristariyanto, Y.A., Abdul Rehman, S.A., Campbell, D.G., Morrice, N.A., Johnson, C., Toth, R., Kulathu, Y.
Deposit date:2015-01-17
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Mol.Cell, 58, 2015
4XYZ
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CRYSTAL STRUCTURE OF K33 LINKED DI-UBIQUITIN
Descriptor:Polyubiquitin-C, 1,2-ETHANEDIOL, IODIDE ION, ...
Authors:Kristariyanto, Y.A., Abdul Rehman, S.A., Choi, S.Y., Ritorto, S., Campbell, D.G., Morrice, N.A., Toth, R., Kulathu, Y.
Deposit date:2015-02-03
Release date:2015-03-18
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem.J., 467, 2015
4Y1H
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CRYSTAL STRUCTURE OF K33 LINKED TRI-UBIQUITIN
Descriptor:Ubiquitin-40S ribosomal protein S27a, 1,2-ETHANEDIOL
Authors:Kristariyanto, Y.A., Abdul Rehman, S.A., Choi, S.Y., Ritorto, S., Campbell, D.G., Morrice, N.A., Toth, R., Kulathu, Y.
Deposit date:2015-02-07
Release date:2015-03-18
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem.J., 467, 2015
6R75
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CRYSTAL STRUCTURE OF HUMAN UBE2T E54R MUTANT
Descriptor:Ubiquitin-conjugating enzyme E2 T
Authors:Chaugule, V.K., Rennie, M.L., Walden, H., Arkinson, C., Kamarainen, O., Toth, R.
Deposit date:2019-03-28
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human Ube2T E54R mutant
To Be Published
5O1S
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DIMETHYL FUMARATE IS AN ALLOSTERIC COVALENT INHIBITOR OF THE P90 RIBOSOMAL S6 KINASES
Descriptor:Ribosomal protein S6 kinase alpha-3, SODIUM ION, Dimethyl fumarate
Authors:Andersen, J.L., Nissen, P.
Deposit date:2017-05-19
Release date:2018-05-30
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.
Nat Commun, 9, 2018
6N13
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UBCH7-UB COMPLEX WITH R0RBR PARKIN AND PHOSPHOUBIQUITIN
Descriptor:E3 ubiquitin-protein ligase parkin, ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Condos, T.E.C., Dunkerley, K.M., Freeman, E.A., Barber, K.R., Aguirre, J.D., Chaugule, V.K., Xiao, Y., Konermann, L., Walden, H., Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2020-01-08
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018