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5EDD
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DUTPASE R140K, H145W MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Nagy, G.N., Leveles, I., Lopata, A., Harmat, V., Toth, J., Vertessy, G.B.
Deposit date:2015-10-21
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural Characterization of Arginine Fingers: Identification of an Arginine Finger for the Pyrophosphatase dUTPases.
J. Am. Chem. Soc., 138, 2016
5ECT
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MYCOBACTERIUM TUBERCULOSIS DUTPASE G143STOP MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Nagy, G.N., Leveles, I., Harmat, V., Vertessy, G.B.
Deposit date:2015-10-20
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural Characterization of Arginine Fingers: Identification of an Arginine Finger for the Pyrophosphatase dUTPases.
J. Am. Chem. Soc., 138, 2016
4MZ6
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STRUCTURE OF IMPORTIN-ALPHA: DUTPASE S11E NLS MUTANT COMPLEX
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1
Authors:Marfori, M., Rona, G., Vertessy, B.G., Kobe, B.
Deposit date:2013-09-29
Release date:2013-11-13
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Acta Crystallogr.,Sect.D, 69, 2013
4MZ5
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STRUCTURE OF IMPORTIN-ALPHA: DUTPASE NLS COMPLEX
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1
Authors:Marfori, M., Rona, G., Vertessy, B.G., Kobe, B.
Deposit date:2013-09-29
Release date:2013-11-13
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Acta Crystallogr.,Sect.D, 69, 2013
4GV8
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DUTPASE FROM PHAGE PHI11 OF S.AUREUS: VISUALIZATION OF THE SPECIES-SPECIFIC INSERT
Descriptor:DUTPase, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, MAGNESIUM ION
Authors:Leveles, I., Harmat, V., Nemeth, V., Bendes, A., Szabo, J., Kadar, V., Zagyva, I., Rona, G., Toth, J., Vertessy, B.G.
Deposit date:2012-08-30
Release date:2013-09-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and enzymatic mechanism of a moonlighting dUTPase
Acta Crystallogr.,Sect.D, 69, 2013
4GCY
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DUTPASE H21W MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Toth, J., Vertessy, B.G., Leveles, I., Bendes, A.
Deposit date:2012-07-31
Release date:2013-07-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:RAMD identification of substrate binding pathways to the active site of dUTPase
To be Published
3LOJ
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DUTPASE H145A MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, GLYCEROL, ...
Authors:Leveles, I., Harmat, V., Pecsi, I., Lopata, A., Vertessy, B.G., Toth, J.
Deposit date:2010-02-04
Release date:2010-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
Nucleic Acids Res., 38, 2010
3IF7
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STRUCTURE OF CALMODULIN COMPLEXED WITH ITS FIRST ENDOGENOUS INHIBITOR, SPHINGOSYLPHOSPHORYLCHOLINE
Descriptor:Calmodulin, CALCIUM ION, 2-{[(R)-{[(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}(hydroxy)phosphoryl]oxy}-N,N,N-trimethylethanaminium
Authors:Kovacs, E., Harmat, V., Toth, J., Vertessy, B.G., Modos, K., Kardos, J., Liliom, K.
Deposit date:2009-07-24
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions
Faseb J., 24, 2010
3I93
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DUTPASE STOP138T MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Leveles, I., Harmat, V., Lopata, A., Toth, J., Vertessy, B.G.
Deposit date:2009-07-10
Release date:2009-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases.
Febs Lett., 584, 2010
3HZA
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CRYSTAL STRUCTURE OF DUTPASE H145W MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Leveles, I., Harmat, V., Pecsi, I., Toth, J., Vertessy, B.G.
Deposit date:2009-06-23
Release date:2009-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase.
Nucleic Acids Res., 38, 2010
3H6D
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STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS DUTPASE D28N MUTANT
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Leveles, I., Harmat, V., Nagy, G., Takacs, E., Lopata, A., Toth, J., Vertessy, B.G.
Deposit date:2009-04-23
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases.
Febs Lett., 584, 2010
3EHW
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HUMAN DUTPASE IN COMPLEX WITH ALPHA,BETA-IMIDO-DUTP AND MG2+: VISUALIZATION OF THE FULL-LENGTH C-TERMINI IN ALL MONOMERS AND SUGGESTION FOR AN ADDITIONAL METAL ION BINDING SITE
Descriptor:dUTP pyrophosphatase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE
Authors:Takacs, E., Barabas, O., Vertessy, B.G.
Deposit date:2008-09-15
Release date:2008-09-30
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site
To be Published
2O1P
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STRUCTURE OF YEAST POLY(A) POLYMERASE IN A SOMEWHAT CLOSED STATE
Descriptor:Poly(A) polymerase
Authors:Bohm, A., Balbo, P., Toth, J.
Deposit date:2006-11-29
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase.
J.Mol.Biol., 366, 2007
2HQU
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HUMAN DUTPASE IN COMPLEX WITH ALPHA,BETA-IMINODUTP AND MAGNESIUM ION
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ...
Authors:Barabas, O., Varga, B., Vertessy, B.G.
Deposit date:2006-07-19
Release date:2007-07-24
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
Febs Lett., 581, 2007
2HHP
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STRUCTURE OF YEAST POLY(A) POLYMERASE IN A CLOSED CONFORMATION.
Descriptor:Poly(A) polymerase, CITRATE ANION, MAGNESIUM ION
Authors:Bohm, A., Toth, J.
Deposit date:2006-06-28
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase.
J.Mol.Biol., 366, 2007
1IKO
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CRYSTAL STRUCTURE OF THE MURINE EPHRIN-B2 ECTODOMAIN
Descriptor:EPHRIN-B2, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Toth, J., Cutforth, T., Gelinas, A.D., Bethoney, K.A., Bard, J., Harrison, C.J.
Deposit date:2001-05-03
Release date:2002-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of an ephrin ectodomain.
Dev.Cell, 1, 2001